Caffeic Acid Phenethyl Ester(CAPE) powder

Caffeic Acid Phenethyl Ester(CAPE) powder is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis, with antineoplastic, cytoprotective and immunomodulating activities. Upon administration, Caffeic Acid Phenethyl Ester(CAPE) powder inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).

       

Product Description

 

Caffeic Acid Phenethyl Ester(CAPE) powder video

 

 


 

I.Caffeic Acid Phenethyl Ester(CAPE) powder basic Characters:

 

Name: Caffeic Acid Phenethyl Ester(CAPE) powder
CAS: 104594-70-9
Molecular Formula: C17H16O4
Molecular Weight: 284.31
Melt Point: 127-129°C
Storage Temp: -20°C
Color: Off-White powder

 


 

II. Caffeic Acid Phenethyl Ester(CAPE) powder in usage:

 

1.Name:

Caffeic Acid Phenethyl Ester(CAPE) powder, 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)acrylate, Phenylethyl caffeate; Phenethyl caffeate; Caffeic acid 2-phenylethyl ester; β-Phenylethyl caffeate;

 

2.Caffeic Acid Phenethyl Ester powder usage:

Protection of the patients against the side effects of chemotherapy and radiotherapy regimens has attracted increasing interest of clinicians and practitioners. Caffeic Acid Phenethyl Ester powder (CAPE powder), which is extracted from the propolis of honeybee hives as an active component, specifically inhibits nuclear factor κB at micromolar concentrations and show ability to stop 5-lipoxygenase-catalysed oxygenation of linoleic acid and arachidonic acid. CAPE powder has antiinflammatory, antiproliferative, antioxidant, cytostatic, antiviral, antibacterial, antifungal and antineoplastic properties. The purpose of this review is to summarize in vivo and in vitro usage of CAPE powder to prevent the chemotherapy-induced and radiotherapy-induced damages and side effects in experimental animals and to develop a new approach for the potential usage of CAPE powder in clinical trial as a protective agent during chemotherapy and radiotherapy regimens.

Caffeic Acid Phenethyl Ester powder (CAPE powder) is the active component of propolis, a honeybee hive product. Caffeic Acid Phenethyl Ester powder is a specific inhibitor of the nuclear transcription factor, NF-κB. CAPE powder has been shown to significantly suppress the lipoxygenase pathway of arachidonic acid metabolism during inflammation. Caffeic Acid Phenethyl Ester powder inhibits HIV-1 integrase, and also inhibits proliferation of transformed cells. It induces apoptosis in transformed fibroblasts, and interferes with EGF signal transduction affecting both protein kinase C and ornithine decarboxylase activity.

Features and Benefits
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds, a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Caffeic Acid Phenethyl Ester powder (CAPE powder) is a bioactive compound of propolis extract. The literature search elaborates that CAPE powder possesses antimicrobial, antioxidant, anti-inflammatory, and cytotoxic properties. The principal objective of this review article is to sum up and critically assess the existing data about therapeutic effects of CAPE powder in different disorders. The findings elaborate that CAPE powder is a versatile therapeutically active polyphenol and an effective adjuvant of chemotherapy for enhancing therapeutic efficacy and diminishing chemotherapy-induced toxicities.

 

3.Warning on Caffeic Acid Phenethyl Ester powder

GHS Hazard Statements
Aggregated GHS information provided by 72 companies from 3 notifications to the CAPE powder C&L Inventory. Each notification may be associated with multiple companies.

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation] H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation] H335 (98.61%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown.

Precautionary Statement Codes
P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501

 

4.Further instructions:

Caffeic Acid Phenethyl Ester(CAPE) powder can be suggested to possess various activities, such as antimicrobial, antioxidant, anti-inflammatory, and cytotoxicity activities. The advance investigations are required about the clinical prospective toxicities of CAPE powder if it is going to be used as a therapeutic agent. Extensive literature is available on some research areas, but still some areas are very much less or not explored; therefore, further investigations to use this common and economic polyphenol for the best therapeutic treatment of ailments are required and proposed.

A variety of in vitro pharmacology and effects in animal models have been reported for CAPE powder, but their clinical significance is unknown. It has antimitogenic, anticarcinogenic, anti-inflammatory, and immunomodulatory properties in vitro. Another study also showed that CAPE powder suppresses acute immune and inflammatory responses in vitro. This anti-cancer effect was also seen when mice skin was treated with bee propolis and exposed to TPA, a chemical that induced skin papillomas. CAPE powder significantly reduced the number of papillomas.

Considering the preceding literature, CAPE powder can be suggested to possess various activities, such as antimicrobial, antioxidant, anti-inflammatory, and cytotoxicity activities. The advance investigations are required about the clinical prospective toxicities of CAPE powder if it is going to be used as a therapeutic agent. Extensive literature is available on some research areas, but still some areas are very much less or not explored; therefore, further investigations to use this common and economic polyphenol for the best therapeutic treatment of ailments are required and proposed.

 

5. Caffeic Acid Phenethyl Ester powder:

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order(Within 1kg)can be sent out in 3 workingdays after payment.

 

6. Caffeic Acid Phenethyl Ester powder Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

7. Caffeic Acid Phenethyl Ester powder Marketing:

To be provided in the coming future.

 


 

III. Caffeic Acid Phenethyl Ester powder HNMR

 

We are Caffeic Acid Phenethyl Ester powder supplie,CAPE powder for sale,Caffeic Acid Phenethyl Ester(CAPE) powder (104594-70-9)≥98% | AASraw

 


 

IV. How to buy Caffeic Acid Phenethyl Ester powder; buy CAPE powder from AASraw?

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


 

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