As we all know, Anti-aging products is a permanent topic and many people study this field for long time, At 2018, there is new drugs for anti-aging and it caused a craze on anti-aging products, this new products called “NMN”. NMN(β-Nicotinamide Mononucleotide) as a new type of anti-aging supplements is very popular. Taking NMN supplements or adding some NMN powder into breakfast is very common seen things since 2020. What information we should know about NMN and how to buy NMN powder online, all questions are concerned by most of people who ready use NMN powder or supplements. Today, we have collect the most discussed topics online from reddit and quora on NMN, hope these answers can help you to know NMN and buy genuine NMN powder online.
What Is NMN Powder?
NMN is short for nicotinamide mononucleotide(CAS:1094-61-7), a naturally occurring molecule present in all species. On the molecular level, it is a ribonucleotide, a basic structural unit of nucleic acid RNA. In form it consists of a nicotinamide group, a ribose and a phosphate group. NMN is a Vitamin B3 (niacin) derivative. It occurs naturally and can be made from dietary sources such as fruits, milk, and vegetables. In the body, NMN is used to generate nicotinamide adenine dinucleotide (NAD+), a powerful and essential molecule that is found in every cell of the body. So, Taking NMN powder is one way in which NAD+ levels in the cell can be increased, then achieve the purpose of anti-aging.
For now, there are several ways to produce NMN raw materials in factory, also called NMN powder. As far as I know, I have known 2 ways from factory which manufacture NMN powder:
Method 1 for manufacture NMN powder: Catalyst method(Industrial Grade)
This manufactured product only for Industrial chemical reaction use, not suitable for human, they will not need to detect the heavy metal, microbiological indicator inside the powder, it is dangerous.
Method 2 for manufacture NMN powder: Enzymatic method(Food Grade)
By this method, the NMN powder is safe for people use, and no Reagent residue, even use external standard method to test the quality, the result still no less 98% purity. (there are some products just simple dry the mother liquid to get the powder, and use the HPLC method to test the purity, it is also no less than 98%, but when it use external standard method to measure, then the difference will obvious.
AASraw is a manufacturer factory to produce NMN powder in China and what method we used is enzymatic method, every batch NMN powder will be tested before sell out and the purity shows 99% min, the quality is stable. We have made agreements with several large supplements company and supply NMN powder for them at long term. There is no doubt that the Enzymatic method is good choice for most of factories. So, please confirm this with your supplier of NMN powder before you buy NMN bulk powder.
What Does NAD+ Have To Do With NMN?
NAD stands for nicotinamide adenine dinucleotide. From bacteria to primates, it is one of the most abundant and crucial molecules in cellular metabolism. In a other way, every body have NAD substance, we would probably die in 30 seconds without the presence of NAD+. That tell us NAD+ is very important substance for our body, it can support our body work as normal every day.
NAD+ works as a shuttle bus, transferring electrons across one cellular molecule to another.It helping turn nutrients into energy as a key player in metabolism and working as a helper molecule for proteins that regulate other cellular functions. These processes are incredibly important.Other functions of NAD+ include regulating the sleep/wake cycle. NAD+ drives sirtuins to regulate metabolism and maintain stable chromosomes. The molecule also helps with repairing damaged DNA.
So, it is very important to keep NAD+ level of our body. That also told us we get younger by increasing NAD+ level, help us fight aging. Then what we should increase our NAD+ level?
As the scientists said, there are three ways to increase NAD+ level:
Adjusted dietary regimen. Diets high in fats and low in carbohydrates, such as keto or Atkins-style diet, promote the state of ketosis. When your body is in ketosis, you use fat for energy instead of glucose. This technique increases the ratio of NAD+ to NADH, thereby protecting your body from oxidation.
NAD+ Supplementation. Your body has a finite ability to produce NAD+, so finding a supplement from a reputable producer who offers purity guarantees is a painless way to boost these levels in your body. These supplements include nicotinamide, nicotinic acid, nicotinamide mononucleotide (NMN), and nicotinamide riboside (NR). 【Nicotinic acid converts to NAD+ through three steps. In the first step, the enzyme NAPRT converts nicotinic acid to nicotinic acid mononucleotide (NAMN). In the second step, the enzyme, NMNAT, converts NAMN to nicotinic acid adenine dinucleotide (NAAD). The enzyme, NAD+ synthetase (NADS) then converts NAAD to NAD+. NAD+ biosynthesis in the salvage pathway involves nicotinamide’ s conversion to NMN via an enzyme, phosphoribosyltransferase, NMNAT. The enzyme converts NMN to NAD+.】
Practicing intermittent fasting. While severe calorie restriction or long periods of fasting are not recommended for most adults, brief or intermittent fasting can show similar results. Intermittent fasting is a more sustainable way of introducing your body to longer periods without eating, raising your NAD+ levels in much the same way as ketosis.
Unfortunately, a high fat-diet may not be advisable if you have diabetes, heart disease, or increased LDL cholesterol. Similarly, fasting may not be advisable for those with medical conditions and is often difficult to continue over time. Thus, supplementing with NMN powders or other NAD supplements is often the safest and most convenient way to promote the increased production of NAD.
After we know NAD+ and how it works, I guess that you must know why we need take NMN powder? How does it works when NMN powder into our body. In a easy way, NMN is the precursor of NAD+ before entering our body. Taking NMN powder can increase NAD+ level and help us beat the speed of aging.
Is NMN Powder Safe Supplements?
Most of the data so far has come from animals, which have not shown any side effects. Long-term mice study also showed no toxicity, serious side effects, or increased mortality rate throughout the 12 month intervention period. As far as we know, A human trial was recently conducted out of Japan. The purpose of the trial was to determine if NMN powder was safe to take. NMN was administered to 10 healthy men. Dosages of 100, 250, and 500 mg NMN were given. The single oral administrations of NMN did not cause any significant clinical symptoms or changes in main biomarkers like heart rate, blood pressure, oxygen saturation, and body temperature. The trial helps to confirm that, in general, NMN powder is safe and well-tolerated; to that end, the trial can be considered a success. This study also measured sleep quality, and found no differences before and after the NMN consumption.
Due to the limited number of human trials, scientists are continuing to explore the side effects of NMN, striving to obtain more clinical data from human trials, in order to ensure that this new anti-aging product is officially launched.
At the same time, we have to talk about Dr. David Sinclair who is one of the 100 most influential people in the world by Time Magazine, has been taking NMN supplements for years with friends in the aging industry. He shared the experience with us after he take NMN powder for long time. He said: “I always takes 1 gram of NMN every day, along with other supplements including resveratrol, metformin, and aspirin. I have not experienced anything other than stomach upset so far.” He also reminded of that we should keep NMN powder in a cool climate or ideally in a fridge, because NMN degrades to Nicotinamide poison your body when NMN is stored in hot/warm temperatures.
What Benefits Can NMN Powder Bring To My Body?
NMN (Nicotinamide Mononuleotide) is a natural precursor of NAD+. NMN supplementation raises DAN+ for essential health & longevity amongst providing other health benefits.NMN powder is in the early stages of human trials and the current benefit claims have been through the success of animal studies. To date, there is no evidence of any adverse effects, even at high doses over a prolonged period of time. It has also shown health benefits in cases of Type II Diabetes and Alzheimer’s Disease.Below are 10 of the top benefits of NMN powder:
♦ Anti-Aging effect
♦ Increases fertility in women
♦ Improves eyesight & vision
♦ Energy booster
♦ Facilitates the repair of broken DNA strands
♦ Improves kidney function & blood flow
♦ Lowers cholesterol & triglycerides
♦ Improves Immune system function
♦ Promotes heart health & function
♦ Improves mitochondrial function by reducing neuroinflammation
Can I Get Enough NMN From Food To Anti-aging?
The answer is “of course not”. Because NMN is found naturally in many foods and you can easy to find them in our life.Below are the six foods highest in NMN:
Now, you must be thinking: “If NMN is found in food, can’t I increase my levels of NAD+ by eating more of those foods?” That’s a good question. However, I should point out that if you want to reverse aging with NMN, you will have to eat large amounts of each of these foods. Sadly, the NMN in a few stems of broccoli is hardly enough to even begin to boost NMN levels.Although NMN occurs in these foods, the concentrations are less than 1 mg per kg of food. In other words, to get about 1mg of NMN, you’d have to eat about 1kg of broccoli!It’s been found that to boost the levels of NAD+ in humans, the levels of NMN should be in the hundreds of milligrams per dose. This is way higher than what we can get from our diets, no matter how much broccoli we eat. So, we must consider about taking NMN powder as supplements to anti-aging in our life, it can help our body increase more NAD+, fighting aging.
How To Take NMN Powder?
In last question, we mentioned Dr. David Sinclair who has taken 1g NMN every day. Then 1g be the most effective dosage for us to get the benefits of NMN, right? “Certainly not!” When working out how much you need to take, it’s important to consider how the NMN is administered and its bioavailability. What’s more, different body with different reaction. We need make out when it is good to take NMN, how to take it and how much dose we should take when you ready to take NMN powder.
Let us talk the first question: How To take NMN powder?
NMN is administered in four options that will affect how much NMN actually makes it into your blood system: powder, sublingual powder, standard capsules, and gastric-resistant capsules.
To understand bioavailability, one has to understand the First Pass Effect(it refers to how much of a substance is destroyed or processed by the liver before it actually passes into the blood system). This is the complicated concept, I guess this video can help us to understand how it works and why it is very important for us to know it before taking NMN powder. Because of the first-pass metabolism, oral consumption of NMN is much less effective than sublingual or gastro-resistant capsules. When NMN powder is taken orally (either when eaten or mixed with a liquid) most of it is destroyed by the stomach acid. The remaining NMN is then metabolized by the liver. How the liver metabolizes NMN can have a huge impact on bioavailability. It may be that only a fraction of NMN actually makes it into your system. Also to improve your NAD+ levels, you can take the delayed-release NMN capsules with a Sirtuin Activator such as a Resveratrol with a full-fat yogurt which helps the bioavailability of Resveratrol.
But when NMN (or any medication or supplement) is taken sublingually, it is absorbed across the mucous membranes (under the tongue) and passes directly into the bloodstream. From there it travels straight to the brain and other organs, bypassing the “first pass effect” from the liver. It is for this reason, that we believe taking sublingual NMN or in a gastric-resistant capsule is the most effective and efficient. It may require lower doses than taking NMN powder orally or in standard capsule form.
The next question: When it is best time to take NMN powder?
Aging is a disease that can be fought with the appropriate combinations of supplements and behaviours, according to new research from the University of Waterloo.Using a comprehensive mathematical model, the researchers also found that the best time of day for someone to take these supplements depends on their age. Some anti-aging supplements should be taken by young people at night, while older people should take it midday for the greatest effectiveness.“The time you eat, what you eat, the time you sleep and the time you exercise are all factors that can affect your body, how you age and how you live,” Researcher Layton said. “People should be mindful of when they eat and ensure that it coincides with other things in their environment that impact their sleep/wake cycle or body clock.
So, when it is best time to take NMN powder? age is the main factor before deciding to how much we take NMN powder. For example, it was studied that NMN supplements are most beneficial for young people to take six hours after waking up. On the contrary, studies show that Resveratrol supplements work best if young people take them in the afternoon. For older adults, it is important to take these supplements in the afternoon.
The last question: How much we should take NMN powder?
After we read the above questions, we must know that every one need find own dosage for NMN powder, not an exact dose as recommendation. Then how can we calculate the NMN dosage for ourselves? As the latest studies, it is related with our weight. From the study: “Given that 100 mg/kg/day of NMN was able to mitigate most age-associated physiological declines in mice, an equivalent surface area dose for humans would be ~8 mg/kg/day, providing hope to translate our findings to humans.” According to the authors of a recent research study, is to take a bare minimum of 8 mg of NMN per kg of body weight per day. If the study are correct, then to find how much NMN you need at the minimum, you would first need to find your weight in kg, then multiply by 8. For example, if your weight is 50kg, the recommended dosage is about 400mg.
If you take a high-quality supplement with excellent bioavailability, like AASraw’s NMN powder, then we recommend the following dosages that are based on customer feedback:
|Weight||Dosage For Reference (daily)|
|45kg||45kg * 8mg = 360mg|
|50kg||50kg * 8mg = 400mg|
|60kg||60kg * 8mg = 480mg|
|70kg||70kg * 8mg = 560mg|
|90kg||90kg * 8mg = 720mg|
|These dosage is only as refence. How much should you take? It’ s up to you. But if you find this particular study convincing, you might to begin your calculations at 8 mg per kg of body weight per day.|
Should I take other supplements with NMN together?
If you’re a good observer,you must have noticed that Dr. David Sinclair take anti-aging supplements every day, not only NMN powder, also have others, such as resveratrol, metformin, and aspirin… Is that must to take other supplements with NMN powder together? Why?
Base on the studies from Dr. David Sinclair and his team,taking NMN powder other supplements is very helpful for anti-aging. For now,I will share 3 supplements when we take NMN powder. 2 supplements are resveratrol and pterostilbene. Resveratrol is a stilbenoid found in the skin of grapes in low amounts. Studies have shown that resveratrol can reduce the risk of heart disease, cancer and neurodegeneration.David Sinclair believes that resveratrol works synergistically with NMN. Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is needed to fuel the sirtuins.However, resveratrol is difficult to be absorbed by the gut, and the little resveratrol that ends up in the body is broken down very quickly.Therefore, pterostilbene is a better alternative. Pterostilbene is a molecule that looks very similar to resveratrol, but it is absorbed considerably better and is far more stable in the human body.
Another supplement is trimethylglycine(TMG),when we take NMN powder for long time, NMN depletes methyl groups within our bodies,as a precaution, it’s thought to be important to take TMG (an amino acid known as betaine) to donate methyl groups. When NMN is converted into NAD+, nicotinamide (NAM) is formed. High levels of nicotinamide are not good for our bodies and in order for our bodies to get rid of nicotinamide it needs to be methylated into N-methyl nicotinamide that is excreted in our urine. In order to methylate NAM, the body theoretically draws from our reserves of methyl groups. The theory is that the more NMN you take, the more methyl groups are required to get rid of the NAM.
In the podcast below with Dr. Mercola, Dr. David Sinclair mentioned that he takes TMG as a precaution to prevent this from happening,we can learn more information from this video of Dr. David Sinclair:
Although most of supplements are reportedly safe and beneficial to our bodies, it’s always best to check with your healthcare practitioner before starting to take it, especially if you have a health condition and are using chronic medication. Always follow the recommended dosage.
Is NMN Good Helpful For Against COVID-2019?
The body’s initial response to an infectious threat like COVID-19, known as innate immune activation, depends on NAD+. Viral infections deplete NAD+ because infections trigger a cellular defense cascade that results in increased NAD+ degradation to prevent the virus from taking over the cell. Significantly reduced NAD+ concentration has been shown in COVID-19 and some researchers think this is a major factor in why this virus is so deadly, especially to those with depleted NAD+ storage. Dr. Zhavoronkov proposed that Testing low-dose rapamycin individually or in combination with metformin, and NAD+ boosters such as nicotinamide riboside (NR), or nicotinamide mononucleotide (NMN) may help protect the elderly from gerolavic infection today and may also enhance economic recovery when the global pandemic is over.
In addition, studies have shown that NAD+ can trigger an immune system response to protect the body from a coronavirus such as COVID-19. A review published March 23, 2020 by Isfahan University of Medical Sciences provides evidence that low NAD+ levels could be tied to higher severity and morbidity rates in the COVID-19 pandemic. According to clinical trials, NMN supplements boost NAD+ to youthful levels. Making the NAD+ molecule available to SIRT1 genes enhances their ability to protect the body against disease and deterioration. As more studies are being conducted, researchers are finding that NAD+ also has an important role to play in regulating our immune systems.
They’ve also found that macrophages (a type of white blood cell that eats potential invaders such as bacteria, fungi, parasites, and viruses) use a pathway synthesized by NAD+ to ensure cell survival and control inflammation. All in all, studies are indicating that NMN and the resulting increased levels of NAD+ can play an important role in helping our bodies fight off infections and bacteria. In other words, it has the potential to boost our immune systems and help them during times of infection and illness.
A case study was published on April 22, 2020 by Dr. Robert Huizenga MD at University of Chicago describing his response to a 55-year old woman who had been hospitalized with COVID-19 on March 16. Her condition continued to worsen and on day 13 she had obvious pneumonia, cytokine storm and extremely elevated hsCRP, a non-specific inflammatory marker. Dr. Huizenga treated her with oral NMN, betaine and NaCl (known to reduce IL-6) and continued the zinc treatment she had been given prior. By day 15, her fever was alleviated and symptoms improved significantly. By day 17 she was discharged to go home. By day 23, she was asymptomatic. Two other elderly patients were treated with the same “cocktail” and both experienced similar recoveries.
NMN VS. NR: Which One Is Better?
Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are biosynthetic precursors to an essential molecule for metabolism–nicotinamide adenine dinucleotide (NAD+).The molecular structures of NMN and NR are roughly the same, except NMN has an added phosphate group. This added phosphate group makes NMN a larger molecule than NR. NR (nicotinamide riboside) and NMN (nicotinamide mononucleotide) supplements are both often touted as two of the most promising supplements to slow down aging.Taking NR and NMN powder increases NAD+ levels. Higher NAD+ levels protect our epigenome and DNA. Increasing NAD+ levels leads to many health benefits on various organs, such as the brain, cardiovascular system, and muscles.
Given that NR and NMN increase NAD+ levels, they are often called NAD boosters. Many studies show that NR and NMN can improve various aging hallmarks, like a dysregulated epigenome, DNA damage, protein accumulation, inflammaging (aging-related inflammation) and various other aging mechanisms.
But the big question of course is: which one is better, NMN powder or NR powder?
Currently, there are no studies comparing NMN and NR head-on regarding health effects and lifespan effects. Let us compare NMN and NR:
How Can I Find The Best NMN Powder?
I believe that you have found many suppliers when you put “NMN powder” on Google, so that you do not know which one is best one or suitable for yourself. We need figure out what we should check when we talk with a NMN powder supplier. For work out this problem, I have talked with many suppliers of NMN powder online and sort out a list for reference:
You need check their website or shops online, make sure that they are a trust supplier, not cheat.Go to their webist or shops, talk with them, ask questions whatever you want. when they answer your questions, you can feel whether it is trust, as we all know, the sincerity is the foundation of all cooperation. When you ask their questions, you can talk about these aspects: NMM powder manufacture, NMN powder certificate, supply capacity of NMN powder….
The best NMN powder will have 99% purity or higher. It will also not contain any fillers or byproducts such as GMOs, dairy, egg, soy, gluten, artificial chemicals, heavy metals, or solvents used in the actual processing of the product. Most fake NMN powder use fillers or stimulants to make up the bulk of the product. This can potentially put your health at great risk because you don’t know what you are taking. If you’re buying your NMN from a company that only sells NMN capsules, it could be anything.
（3）Related Documents — Testing Reports
As NMN powder factory,the related documents(COA,HPLC,HNMR,MS) will be come out after they produce a batch products,they need check its quality, send it to 3rd-labs to do test(this includes purity, contaminants, and heavy metals.), make sure that it is up to the standard and can sell it in market.As a customer, you should be able to request to see these reports,espcially for COA and HPLC. You can check the supplier’s website for third-party testing information, or contact their customer service directly. Verification of third-party testing is a simple way to ensure you’re buying from a reputable source. Any company using third-party testing should be happy to share that information with you.
（4）Compare The Price Between Several Suppliers
NMN Price is another metric that you can use to gauge supplier suitability, by checking a number of NMN suppliers for both powder and capsules you will get an idea of the average price per gram.If you only consider about the price in market, you must beware of the fake NMN powder, or lower quality products. It’s always tempting to want to save money any chance you can, but with NMN specifically, you get what you pay for. Low-cost NMN will likely be food-grade, not pharmaceutical grade, which means the NMN benefits aren’t the same.The cheaper options of NMN, that are currently on the market, are food grade and may well contain contaminants. In fact, there is sometimes less than 10% NMN in food-grade NMN. To test this out, we had a food-grade NMN sample tested and it came back with 8% NMN.Considering your budget is important, but you may end up paying more in the long run when opting for lower-priced NMN products if you don’t see any health benefits from them.
（5）Excellent Customer Service
Quality NMN comes from quality suppliers, the reliable supplier should have excellent customer service. When you talk with customer respresentive, send all questions to them and they will answer you soon.In addition, let you know whole purchase process, how to do it and let you know what you should to do for next step, the whole process should be tracked by yourself. Please rememeber that a good customer service is someone who feels comfortable communicating with each other at any time.
（6）Reviews from Other Clients
As general, we can find some reviews about that company if a company have provide NMN powder for long time, or they can provide some feedbacks from other clients. After all, we can know it is truth as long as they have sale record and real feedback of clients. Of course, we must know that the reviews from other clients only as reference when we decide to buy NMN powder, it depend on you at finally.
AASraw is the company who has certificated factory, can bulk produce NMN powder and other anti-aging supplements, the supply is stable. You go to their website-www.aasraw.com at any time and ask their customer service, ask the quality certificate and testing reports in 3rd-lab, confirm that their NMN powder is 99% purity pharmacetical grade and it is top one. As far as I know, they can send the product out which you ordered in 1-3 working days, even 12 hours after order confirmed, the work efficiency is very high, I have to give them a thumbs up for that. You will get the NMN powder picture and tracking number from them after order, then you can use track the parcel online and know where it is, how far aways from your home. Learn more about AASraw now
How To Store NMN Powder?
Nicotinamide riboside(NR) and nicotinamide mononucleotide(NMN), have been shown to ameliorate age-associated diseases in animals. They are well-tolerated at high doses and effectively raise NAD+ levels. These molecules are not shelf-stable at high temperatures or in conditions of high humidity, however. They quickly degrade into nicotinamide, which inhibits the activity of sirtuins and PARP, a DNA repair enzyme.For best results, NMN powder should be kept in their original containers and away from any source of water. NMN powder not ingested for 3 months or longer may be refrigerated to ensure they maintain full potency. As the worldwide leader, AASraw always provides the absolute highest quality and most effective NAD+ and NMN powder available.
Is There Any Real Reviews on NMN Powder?
Tom from UK: My wife and I started taking NMN powder several months ago and we were astonished I stopped snoring and my wife’s skin problems started to diminish ! We just feel better clarity of mind also way more energy,i have never taken a supplement that I have had a noticeable reaction to I mean you take multi vitamins and herbal supplements but never really feel the results! This is the most incredible supplements man kind has discovered yet and just the possibly of restoring the millions of cells in the human body is a amazing discovery for the aging process! I think everyone will know of this pill in the near future and cancer research will take notice as well,we are in are 50’s and can’t say enough about how different we feel ! Who wouldn’t want to feel healthier adding this to your anti-aging supplements intake will change your life for the better trust me !!!
liMei from China: I chose NMN powder because I read it helps to oxygenate the blood and delivers oxygen to my body tissues. My body was calling for this product, I was feeling fatigued and unable to concentrate. I have been taking NMN powder for two weeks now. I have seen an increase in energy, I am able to participate in an intense cardio exercise program after working all day. My thoughts are clear, I am not feeling drowsy in meetings. I am very happy with NMN supplements I am getting the results I have been looking for. In addition, I must said: NMN price is a little high for me but I want insist on taking it, because I want to be more younger, haha…
Gary from Australia: This is a great anti-aging supplements. I notice increased energy, I did not catch my 4 year old’s cold, and I don’t tire as easily. The kind of energy I feel is different from a caffeine high. I don’t feel anxious or over-stimulated, just really alert and fresh. Despite the alertness, my sleep has improved. I have never had a problem sleeping, but I can wake up a lot during the night. With the NMN powder I sleep longer in a stretch. I think NMN is benefiting me in many ways and I just can’t speak highly enough about it.
Steven from USA: After learning about NMN powder and it’s possible effects from Harvard Study conducted by Dr. David Sinclair, I decided to give it a try. From the first day I tried it, I noticed a difference in my energy level. I’m 57 years old, and my metabolism appears to be changing for the better. I have not changed my diet habits, yet I am losing weight, 14 lbs in 4 weeks. That time span is indicative of permanent loss. My wife has lost 9 lbs, and she suffers from a rare disorder called Erythromelalgia, which causes the extremities to get very hot with neuropathic pain, and it is consistent. The Niacin part of the compound, in addition to her medicines, has made the pain lessen somewhat, and enabled more functionality. After I ran out the first time – I tried the one from another NMN powder suppliers. It’s compound is different, and the energy dissipated. That’s why I came back to MAAC10, and now I’m back on track. You know, I even believe some of my widespread gray hair has darkened without dye. It works You know – I don’t think I look 57 anymore either.Anyway,thank for this miracle supplements-NMN powder and thank for aasraw.
While the Fountain of Youth remains a fantastical myth that isn’t likely to come true any time soon, the science behind anti-aging medication continues to advance. Perhaps one day, you’ll be able to take a miracle pill and experience life as a young adult once again. Studies in animals showed NMN’s promising properties in NAD+-boosting and anti-aging. Now, Although the researchers are moving forward with clinical trials to investigate the safety and efficacy of the molecule in humans.Until then, NAD and NMN supplements offer real benefits to slow the drastic effects of cell aging on the human body. I believe that it will be helpful as long as they are benefical for our body, Let’s get young again together.
 North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michan, S., Dai, J., … & van Deursen, J. M. (2014). SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. The EMBO journal, e201386907.
 Kiss, T., Nyúl-Tóth, Á., Balasubramanian, P., Tarantini, S., Ahire, C., Yabluchanskiy, A., … & Ungvari, Z. (2020). Nicotinamide mononucleotide (NMN) supplementation promotes neurovascular rejuvenation in aged mice: transcriptional footprint of SIRT1 activation, mitochondrial protection, anti-inflammatory, and anti-apoptotic effects. GeroScience, 1-20.
 Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., … & Imai, S. I. (2019). Slc12a8 is a nicotinamide mononucleotide transporter. Nature metabolism, 1(1), 47-57.
 Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J., … & Sinclair, D. A. (2017). A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science, 355(6331), 1312-1317.
 Stipp D. Beyond Resveratrol: The Anti-Aging NAD Fad. Scientific American Blog Network. March 11, 2015.
 Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC. + Decline. Cell Metabolism. May 2018, 27 (5): 1081–1095.e10. PMC 5935140. PMID 29719225. doi:10.1016/j.cmet.2018.03.016.
 Bogan KL, Brenner C. Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. Annual Review of Nutrition. 2008, 28: 115–30. PMID 18429699.
 Fletcher RS, Lavery GG (October 2018). “The emergence of the nicotinamide riboside kinases in the regulation of NAD+ metabolism”. Journal of Molecular Endocrinology. 61 (3): R107–R121. doi:10.1530/JME-18-0085. PMC 6145238. PMID 30307159.