Everything about Bromantane powder
|1.Chemical properties of Bromantane|
| 2.Bromantane General description
|3. Bromantane powder Use|
|4.Bromantane powder Mechanism of action|
| 5. Bromantane powder Dosage
Bromantane powder is a stimulant with anxiolytic properties developed in Russia in the late 80’s that acts mainly by inhibiting the reuptake of dopamine and serotonin in the brain, although it also has cholinergic effect at high doses. The results of the studies suggest that the combination of the psychostimulant and anxiolytic effect is effective to treat asthenic manifestations. It boosts the performance of the muscle and is used as a psychostimulant and immune stimulant.
In the past, it was used for doping, and in the Atlanta Olympics in 1996 , several people showed a positive response in the test. After that, it was banned for use as a stimulant and a masking agent , and it is described as a stimulant in the list of prohibited substances of the world anti-doping regulation. Studies of drugs of this classification are widely performed, and many derivatives are known, but research on bromanthan is the most advanced. Human tests, such as improvement of tolerance in extreme conditions, have also continued.
Studies have shown that the combination of the effects of bromanthan’s stimulant and anxiolytic drugs is more effective in treating asthenia compared to placebo
1. Chemical properties of Bromantane
Molecular formula: C16H20BrN
Application: orally (tablets)
Biological half-life: 11.21 hours (in humans)
7 hours (in rats)
Bromantan is simply nootrop, 50-100mg dosage for light stimulation, positive mood, light clearhead, better focus, in larger (150-250mg +, depending on what experience we have with stims) there is a light mania, no physical stimulation.
Bromantan is a stimulant that helps improve athletic performance. The 26th Olympic Games in 1996In Atlanta, USA, in view of the international doping scandals, the IOC made detailed preparations before the Olympic Games, including the specialization of drug testing experts from the United States and Germany and the purchase of superb testing facilities.
The use of this drug is common; in addition, it has not included in the IOC’s banned list. Kolesov also insisted that they wrote to the IOC Medical Committee two years ago to ask whether Bromantan was a banned drug, but it has not been answered, so it is considered safe.
Officials of the International Olympic Committee Medical Committee denied the incident and considered the drug to be a mixture of steroids and several other stimulants and masking agents, and there is a supplementary provision in the IOC’s list of banned drugs, as long as Drugs that improve athletes’ performance can be considered illicit drugs. Both sides have their own opinions.
These drugs have a wide range of biological effects, in particular stimulating and anxiolytic properties, the main pharmacological effect is a stimulating effect on the central nervous system, which manifests itself in increasing physical and mental performance, slowing the development of fatigue and accelerating recovery after intense physical and mental stress.
Pharmacological regulation of fatigue can be carried out:
• psychomotor stimulants (exhausting mainly energy reserves);
• energy-producing compounds (the maximum effect is noted at the time of administration);
• regulators of metabolism (substances that selectively regulate or block the metabolic pathways).
Actoprotectors are referred to metabolic drugs of non-depleting type of action, which may also have, to a greater or lesser degree, antihypoxic activity. Drugs differ from antihypoxants in that they primarily stimulate the synthesis of proteins and increase their efficiency. In addition, they have an antihypoxic effect in hypoxic conditions, which develop due to the reduced ability of mitochondria to oxidize substrates at increased physical exertion, and not under hypoxic conditions of other etiology.
When administered orally, the drug is quickly, but not completely absorbed from the gastrointestinal tract into the blood (bioavailability is 42%), quickly and in large quantities distributed in organs and tissues, but is slowly removed from the body. Deposited in adipose tissue. The rate of absorption of bromantane from the gastrointestinal tract in women is much higher, respectively, the half-life is shorter than that of men. The time to reach the maximum concentration of bromantane in the blood in women averages 2.75 hours, and in men – 4 hours. The drug is metabolized in the liver, and its elimination occurs predominantly by the extrarenal route.
The amino-adamantane derivative – bromantane, which has combined stimulatory and anxiolytic effects, increases physical and mental performance, slows the development of fatigue processes, accelerates recovery in normal and complicated hypoxia and hyperthermia conditions, improves mnestic processes, training; improves the coordination of movements, raises the body temperature, has a neuropsychoaktiviruyuschim action (so it is sometimes referred to as psychomotor stimulants), shows antagonism with respect to the sedative effect of tranquilizers, a positive inotropic effect without affecting the chronotropic function of the heart and systemic blood pressure, has immunomodulating activity.
A positive effect of bromantane on the parameters of the psychophysiological state was established – the volume and stability of attention, a complex sensorimotor reaction, parameters of the success of the operator activity. The mechanism of action of bromantane is based on the ability to increase the activity of the subcortical centers of the central nervous system (the nuclei of the hypothalamus, the reticular nuclei of the tire, the hippocampus). The drug has no pronounced effect on noradrenergic mediators, but realizes the activating properties through the dopaminergic system. Presence of central serotonin blocking effects is also suggested. A certain role in the realization of the pharmacological action of bromantane is played by its antiradical and membrane-protective properties. The protective effect of bromantane is enhanced when it is used together with bemitil.
The drug has no pronounced effect on noradrenergic mediators, but realizes the activating properties through the dopaminergic system. Presence of central serotonin blocking effects is also suggested. A certain role in the realization of the pharmacological action of bromantane is played by its antiradical and membrane-protective properties. The protective effect of bromantane is enhanced when it is used together with bemitil. The drug has no pronounced effect on noradrenergic mediators, but realizes the activating properties through the dopaminergic system. Presence of central serotonin blocking effects is also suggested. A certain role in the realization of the pharmacological action of bromantane is played by its antiradical and membrane-protective properties. The protective effect of bromantane powder is enhanced when it is used together with bemitil