Everything about Dutasteride powder


  1.What is Dutasteride powder?
  2.What is the use of Dutasteride powder?
  3. What Should I Take Dutasteride powder dosage?
  4.Function of Dutasteride powder 
  5.How does Dutasteride powder works ?
  6.What is the half life of Dutasteride powder?
  7.What are the side effects of Dutasteride powder?
  8.Warmings on Dutasteride powder
  9.How Does Dutasteride powder Help with Hair Regrowth?
  10.Dutasteride powder and finasteride comparisons
  11.Dutasteride powder vs Finasteride, Which Raw Material Powder Is Better?
  12.Are there more risks with Dutasteride powder than Finasteride ?



Dutasteride powder video



I.Raw Dutasteride powder basic Characters:


Name: Dutasteride powder
CAS: 164656-23-9
Molecular Formula: C27H30F6N2O2
Molecular Weight: 528.53
Melt Point: 242-250°C
Storage Temp: -20°C Freezer
Color: white to beige powder



1. What is Dutasteride powder?aasraw


Dutasteride powder is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase, an intracellular enzyme that converts testosterone to DHT. Dutasteride powder usually sold under one brand name of Avodart, is a oral medication used primarily to treat enlarged prostate in men, This is a condition that causes you to have an enlarged prostate. Dutasteride raw powder helps to control your symptoms, decrease urinary retention, and reduces your risk of needing surgery. it can also be used to treat scalp hair loss in men, excessive hair growth in women, and as a part of hormone therapy for transgender women.

Dutasteride powder is chemically designated as (5α,17β)-N-{2,5 bis(trifluoromethyl)phenyl}-3-oxo-4- azaandrost-1-ene-17-carboxamide. The empirical formula of Dutasteride raw powder is C27H30F6N2O2, representing a molecular weight of 528.5 with the following structural formula:


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Dutasteride raw powder is a white to pale yellow powder with a melting point of 242° to 250°C. It is soluble in ethanol (44 mg/mL), methanol (64 mg/mL), and polyethylene glycol 400 (3 mg/mL), but it is insoluble in water.

Each AVODART soft gelatin capsule, administered orally, contains 0.5 mg of Dutasteride powder dissolved in a mixture of mono-di-glycerides of caprylic/capric acid and butylated hydroxytoluene. The inactive excipients in the capsule shell are ferric oxide (yellow), gelatin (from certified BSE-free bovine sources), glycerin, and titanium dioxide. The soft gelatin capsules are printed with edible red ink. Dutasteride raw powder is sometimes given with another medication called tamsulosin (Flomax). Be sure to read the medication guide or patient instructions provided with each of your medications.



2. What is the use of Dutasteride powder?aasraw


Dutasteride powder prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH). Dutasteride powder is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate. Dutasteride raw powder helps improve urinary flow and may also reduce your need for prostate surgery later on.

Dutasteride powder is sometimes given with another medication called tamsulosin (Flomax).

Usual Adult Dose for Benign Prostatic Hyperplasia:

0.5 mg orally once a day

Use: Treatment of symptomatic benign prostatic hyperplasia (BPH) in men with an enlarged prostate to reduce the risk of acute urinary retention (AUR) and BPH-related surgery.

Dutasteride raw powder Raw powder comes as a capsule to take by mouth. It is usually taken once a day with or without food. Take Dutasteride powder raw powder at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Dutasteride raw powder raw powder exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the capsules whole; do not open chew, or crush them.

Your symptoms may improve after you have taken Dutasteride powder raw powder for 3 months, but it may take 6 months or longer for you to see the full benefit of Dutasteride raw powder raw powder. Talk to your doctor about how you are feeling during your treatment.

Dutasteride powder raw powder may control your symptoms but will not cure your condition. Continue to take Dutasteride powder raw powder even if you feel well. Do not stop taking Dutasteride powder without talking to your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient.

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3. What Should I Take Dutasteride powder dosage?aasraw


You should only take the dose as recommended by your doctor. Do not change the Dutasteride powder dosage without consulting your doctor.

Effectiveness of Dutasteride raw powder has been evaluated at different daily dosages, ranging from 0.01mg, 0.05mg, 0.5mg, 2.5mg, and 5.0mg per day. It was found that by using 0.5mg per day of Dutasteride powder patients achieved a significant reduction in DHT concentration compared to those using 5mg of Finasteride. In non-comparative clinical trials, chronic therapy with Dutasteride raw powder (0.5 mg daily) for up to 2 years in patients with BPH resulted in median reductions in serum DHT of 93%.4. In contrast, therapy with finasteride (5 mg daily) suppressed serum DHT concentrations by approximately 70% for up to 4 years in patients with BPH. Please consult the results here.

Dutasteride raw powder is very effective in small doses. DHT inhibition is close to 90% at a daily dose of 0.5mg, In addition, the level of DHT suppression is not significantly greater between 2.5mg and 5.0 mg.

  • For Treating Hair loss

Dutasteride powder, at 2.5mgs/day is roughly 1.5x more effective than Finasteride at 5mgs/day, at treating hair loss (both           halting it as well as regrowing it).

Dutasteride raw powder, In addition, It can be used successfully at that same dose to treat prostate enlargement, and a                     lesser known effect of Dutasteride powder (again, at that same dose) use is to treat Acne caused by an overabundance of                       androgens in the body

For anyone considering using Dutasteride raw powder to combat their male-pattern baldness, below charts should come in handy. The first one shows the amount of DHT inhibited by Dutasteride powder in concentrations of .1mg per day, .5 mg per day, and 2.5 mg per day. .5 mg per day is the dose prescribed to BPH (benign prostatic hyperplasia) sufferers and is often the dose taken by hair loss sufferers.


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The next chart shows the amount of DHT inhibited by Dutasteride powder on different dosing schedules. The lines are kind of hard to see so I’ll list them here:

  • Purple line: 1.5 mg per day (3 Avodart pills) for 10 days and then .5 mg per day thereafter
  • Blue line: .5 mg per day
  • Green line: .5 mg per day for 2 days, then take one day off, then repeat
  • Red line: .5 mg every other day
  • Black line: Finasteride (Propecia/Proscar 1 mg per day) equivalent.


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As you can see, loading with 1.5 mg per day and then taking .5 mg per day thereafter inhibits the largest amount of DHT the fastest. You can achieve the same rate of inhibition with taking .5 mg per day from the start but it will take time to build in your system to its maximum levels of inhibition.When we started Dutasteride powder (and discontinued Finasteride) we can went ahead and took the loading method. Nobody have no any side effects with Dutasteride raw powder thus far other than a brief shedding period that lasted about a month-and-a-half starting at around the two month mark. Our most clients using Dutasteride powder for about a year-and-a-half now with great results.



4. Function of Dutasteride powder powderaasraw


A- Used in the treatment of benign prostatic hyperplasia, enlarged prostate, improve urination.
B- Reduce acute urinary retention and surgical risk
C- Can also be used to treat male pattern baldness (androgen alopecia) can promote hair growth and prevent continue to hair loss.

Dutasteride powder, along with Finasteride is a 5-alpha-Reductase inhibitor which are a group of drugs with anti-androgenic properties which inhibit the conversion of testosterone into dihydrotestosterone (DHT). It’s usaully marketed pharmaceutically as Avodart, Avidart, Avolve, Duagen, Dutas, Dutagen, Duprost. For unknown reasons, early clinical trials for Dutasteride powder were abruptly ceased in 2002, then continued later.

This is the same chemical found in Proscar and Propecia and is used in the treatment hyperplasia and androgenic alopecia.

Because these drugs reduce levels of dihydrotestosterone (DHT) they are used to prevent and treat hairloss. It is most commonly used to treat enlarged prostate glands.



5. How does Dutasteride powder works ?aasraw


Dutasteride powder belongs to a class of drugs called 5 alpha-reductase inhibitors. A class of drugs refers to medications that work similarly. They’re often used to treat similar conditions.
There is a hormone in your blood called dihydrotestoterone (DHT), which causes your prostate to grow. Drugs like Dutasteride powder prevent the formation of DHT in your body, causing an enlarged prostate to shrink.

Dutasteride powder raw powder is a synthetic 4-azasteroid compound that is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5 alpha-reductase (5AR), intracellular enzymes that convert testosterone to 5 alpha-dihydrotestosterone (DHT). Type I 5a-reductase is predominant in the sebaceous glands of most regions of skin, including scalp, and liver. Type I 5a-reductase is responsible for approximately one-third of circulating DHT. The Type II 5a-reductase isozyme is primarily found in prostate, seminal vesicles, epididymides, and hair follicles as well as liver, and is responsible for two-thirds of circulating DHT.



6. What is the half life of Dutasteride powder?aasraw


The terminal elimination half-life of raw Dutasteride powder is approximately 5 weeks at steady state. The average steady-state serum Dutasteride powder concentration was 40 ng/mL following 0.5 mg/day for 1 year.



7. What are the side effects of Dutasteride powder?aasraw


1)More common side effects

The most common side effects that occur with Dutasteride powder include:

  • trouble getting or keeping an erection (may continue after stopping Dutasteride powder)
  • ejaculation problems (may continue after stopping Dutasteride raw powder)
  • decrease in sex drive (may continue after stopping Dutasteride powder)
  • enlarged or painful breasts. If you notice breast lumps or nipple discharge, talk to your doctor.

If these effects are mild, they may disappear within a few days or a couple of weeks. If they’re more severe or don’t disappear, talk to your doctor or pharmacist.


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2)Serious side effects

  • allergic reactions. Examples include:
  • prostate cancer. Symptoms may include:
  • swelling of your face, tongue, or throat:
  • increased prostate-specific antigen (PSA) concentrations:
  • increased urination frequency:
  • difficulty starting urination:
  • peeling skin:
  • painful/burning urination:
  • weak urine flow:
  • difficulty in having or maintaining an erection:
  • blood in the urine or semen:
  • painful ejaculation:
  • frequent pain or stiffness in the lower back, hips, or upper thighs:

This is not a complete list of Dutasteride powder side effects. Ask your doctor or pharmacist for more information.



8. Warmings on Dutasteride powderaasraw


Dutasteride powder should never be taken by a woman or a child. Dutasteride powder can be absorbed through the skin, and women or children should not be permitted to handle Dutasteride raw powder raw powder capsules.

Although Dutasteride powder raw powder is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride raw powder capsules should not be handled by a woman who is pregnant or who may become pregnant.

Do not chew, crush, or open a Dutasteride raw powder raw powder capsule. Swallow the capsule whole. Dutasteride powder can irritate your lips, mouth, or throat if the capsule has been broken or opened before you swallow it.

If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away.

Before taking Dutasteride powder raw powder, tell your doctor if you have ever had an allergic reaction to this medication, or to a similar medicine called finasteride powder (Propecia, Proscar).

Using Dutasteride raw powder may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using Dutasteride powder raw powder.

Do not donate blood while taking Dutasteride powder and for at least 6 months after your treatment ends. Dutasteride raw powder raw powder can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains Dutasteride powder.



9. How Does Dutasteride powder Help with Hair Regrowth?aasraw


Men who suffer from male pattern hair loss or BPH both have a high level of the hormone that is known as dihydrotestosterone, or DHT. This hormone is produced from your body’s natural testosterone by the enzyme 5-alpha reductase.

AASraw Biochemical research has shown that men who have substantial hair loss and those who have BPH both have higher levels of this enzyme in their scalp or bloodstream.

Alternatively, men who do not have either of these conditions have much lower levels of the enzyme present.

Dutasteride powder works by preventing the effects of the 5-alpha reductase enzyme, which blocks the formation of DHT. That pauses a trigger element in the development of hair loss in men, as well as the development of BPH.

It helps to increase the number of scalp hairs and fills in the thin areas.

The results of taking Dutasteride raw powder will vary from one person to the next. Typically, users do not re-grow back all the hair that they have lost.

While DHT is a condition that occurs gradually, taking Dutasteride powder can help to delay the process of hair loss.

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10. Dutasteride powder and finasteride comparisonsaasraw


Dutasteride powder and finasteride are very similar Powder, the following table lists is their features.

Dutasteride powder Finasteride
Use treatment of benign prostatic hyperplasia treatment of benign prostatic hyperplasia*
Is a generic version available? yes yes
Form Powder Powder
Strength 0.5 mg 5 mg
How do I take it? by mouth by mouth
How often do I take it? once daily once daily
Do I take it for long-term or short-term treatment? long term** long term**
How do I store it? between 68°F and 77°F (20°C and 25°C) between 68°F and 77°F (20°C and 25°C)

*Finasteride can also be used to treat male pattern hair loss.
**Treatment usually continues for the rest of your life.



11.Dutasteride powder vs Finasteride, Which Raw Material Powder Is Better?aasraw


The importance of dual 5a-reductase inhibition in the treatment of male pattern hair loss.

Olsen E. et. al.


In the study, 416 men with male pattern hair loss (MPHL) ages 21 to 45 years old, were randomized to receive Dutasteride raw powder 0.05, 0.1, 0.5 or 2.5 mg, finasteride 5 mg, or placebo daily for 24 weeks. The results of the study showed that Dutasteride powder increased hair counts in a dose-dependent fashion and Dutasteride raw powder 2.5 mg was superior to finasteride 5mg at 12 and 24 weeks.

Although testosterone is the major circulating androgen, to be maximally active in scalp hair follicles it must first be converted to dihydrotestosterone (DHT) by the enzyme 5?-reductase. The importance of DHT as a causative factor in male pattern hair loss is shown by the absence of this MPHL in men with a congenital deficiency of the type 2 5?-reductase enzyme. A type 1 5?-reductase, which also metabolizes testosterone to DHT, differs in its location and amount in different tissues. In the skin, type 1 5?-reductase is the principal isoenzyme in sebaceous and sweat glands. There is no recognized genetic deficiency of type 1 5?-reductase in humans to assess its role in MPHL.

Dutasteride powder (Avodart) inhibits both type 1 and type 2 5?-reductase and is approved at the 0.5-mg dose for treatment of symptomatic benign prostatic hyperplasia (BPH). It is about 3 times as potent as finasteride at inhibiting type 2 5?-reductase and more than 100 times as potent at inhibiting the type 1 5?-reductase enzyme.

Dutasteride raw powder caused scalp and serum dihydrotestosterone levels to decrease and testosterone levels to increase in a dose-dependent fashion. Whereas 5-mg finasteride decreases serum DHT by about 70%, Dutasteride powder can decrease serum DHT by more than 90%.


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In this phase II, dose-ranging study, 2.5-mg Dutasteride raw powder was superior to 5-mg finasteride in improving scalp hair growth in men between ages 21 and 45 years with MPHL as judged by target area hair counts, expert panel assessment, and investigator assessment at 12 and 24 weeks.

In a test area at 24 weeks, results showed:

Placebo -32.3 hairs
Finasteride 5mg 75.6 hairs
Dutasteride powder 0.1 mg 78.5 hairs
Dutasteride powder 0.5 mg 94.6 hairs
Dutasteride powder 2.5 mg 109.6 hairs


Dutasteride powder 2.5mg vs. 0.5mg

The 2.5-mg Dutasteride raw powder dose was consistently superior to 0.5-mg Dutasteride powder in promoting scalp hair growth. The 2.5-mg dose was also better than the 0.5-mg dose at suppressing scalp DHT (79% vs. 51%), whereas it was only marginally better at suppressing serum DHT (96% vs. 92%). This difference in the dose-response of serum and scalp DHT to inhibition with Dutasteride raw powder is likely to be due to the greater contribution of type 1 5?-reductase to scalp DHT concentrations.


Finasteride 5mg vs. Dutasteride raw powder 0.1mg

5 mg finasteride suppressed scalp DHT to a similar degree as 0.1 mg Dutasteride powder group (41% and 32%, respectively). Many of the clinical effects (hair count changes, global panel assessment, and investigator assessment) were also similar in these two groups, supporting the similarity in scalp suppression between 5-mg finasteride and 0.1-mg Dutasteride powder.


Adverse Effects

Both Dutasteride powder and finasteride powder were well tolerated in this phase II study, and no new safety concerns have arisen in any of the phase II and phase III studies of Dutasteride powder given at doses up to 5 mg daily (the 5-mg dose was used in a phase II study for BPH).

There were no significant differences in side effects, serious adverse events, or withdrawals due to adverse events among any of the treatment groups, including placebo. In total, 11 subjects withdrew because of adverse events: 3 were in the placebo group (irritable bowel syndrome and impotency), 7 in the Dutasteride raw powder 0.1 mg group (decreased libido, malaise and fatigue, mood disorders, skin disorders, injuries caused by trauma, and gastrointestinal- and neurology-related complaints) and 1 in the Dutasteride powder 0.5 mg group (gastrointestinal discomfort and pain).

Decreased libido was noted in:

  • 2 subjects in the placebo group
  • 2 subjects in each of the 0.05-mg and 0.1-mg Dutasteride raw powder groups
  • 1 subject in the 0.5-mg Dutasteride powder group
  • 9 subjects in the 2.5 mg Dutasteride raw powder group
  • 3 subjects in the finasteride group

Of the 9 subjects with decreased libido in the 2.5-mg Dutasteride powder group:

  • 4 resolved while receiving therapy
  • 1 resolved within 3 weeks
  • 1 resolved within 8 weeks of stopping drug therapy
  • 1 subject, decreased libido continued after therapy had been stopped and was presumed by the subject to be unrelated to the trial or drug therapy

Concerning possible sexual adverse events, there was no evidence in the present study that either Dutasteride raw powder or finasteride powder was associated with impotence. However, 9 men in the 2.5-mg Dutasteride powder group complained of decreased libido, compared with 1 man in the 0.5-mg Dutasteride powder group and 3 men in the finasteride group. As with previous studies with finasteride, this adverse event was characterized as either mild or moderate in severity and often resolved with continuation of the medication. In the 4-year follow-up of the phase III trials in BPH, Dutasteride raw powder (0.5 mg) was well tolerated and the incidence of the most common sexual adverse events was low and tended to decrease over time.

The only subject to develop gynecomastia was in the placebo group.


Duration of Effects

The serum half-life of finasteride is 6 to 8 hours. Dutasteride raw powder has a serum half-life of approximately 4 weeks, and this long half-life was evident in the persistent suppression of DHT with the 0.5-mg and 2.5-mg doses after Dutasteride powder treatment was stopped. Because of this long half-life, men being treated with Dutasteride powder should not donate blood until at least 6 months past their last dose to prevent administration to a pregnant female transfusion recipient.



12. Are there more risks with Dutasteride powder than Finasteride?aasraw


The answer is possibly. Finasteride raw powder only blocks the type 2 isoenzyme of 5-alpha reductase, where Dutasteride raw powder blocks both the type 1 and type 2 isoenzymes of 5-alpha reductase.

There is a genetic model of patients without type 2-5 alpha reductase. There is a small group of the human population that has a genetic defect which causes them not to produce type 2 5-alpha reductase. These people live healthy lives without any increased disease risk (In matter of fact, they do not experience male pattern hair loss, their prostates do not enlarge, and they do not develop prostate cancer). Furthermore, Finasteride powder has been taken by humans going on 20 years without seeing any long term side effects. Therefore, the medical community feels very comfortable blocking type 2 5-alpha reductase, which again is what Propecia® does.

There is no genetic model of humans not having type 1 5-alpha reductase. There are type 1 5-alpha reductase receptors throughout the body, including the brain. The medical community does not know the implications to long term suppression of type 1 5-alpha reductase. Therefore the medical community does not know if there are long term implications to suppressing type 1 5-alpha reductase, which Dutasteride powder blocks.




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