Everything about Dobutramine Powder
Dobutramine Powder video
I.Raw Dobutramine Powder basic Characters:
|Color:||White or off white crystalline powder|
What’s ? From the name, it is much like the familiar products–Sibutramine. What’s the difference between them? In this article, we are trying to find some truth.
1.What’s Dobutramine Powder used for?
After doing some research on this products, we found it is used as a diet goods for weight loss, like its similar name as Sibutramine. There are evidences to support this opinion:
Dobutramine Powder, with the same mechanism of sibutramine, is an orally administered agent for treatment of obesity. Study also shows that, this product and its amine activated metabolin have no evident prohibiting effects, such as choline-resisting, histamine-resisting, and monoamine oxidase. The weight-losing effect of Babutramine is more excellent than sibutramine, its side effect is smaller, and it can’t be detected.
Name: Dobutramine Powder
Molecular Formula: C17H26NCl
Molecular Weight: 180.28
Melt Point: 110.2°C
Storage Temp: Refrigerator
Color: White or off white crystalline powder
From the above description and chemical characters, it is very similar to Sibutramine. This product is acting on the central obesity treatment drug. Mainly through its amine (amine and Primary Amine) metabolites generated effects, the main mechanism for the inhibition of norepinephrine and 5 – hydroxytryptamine and dopamine reuptake and enhanced sense of satiety, while norepinephrine, 5 – serotonin and dopamine release was observed. Dobutramine Powder Weight-reduction pharmaceuticals which is better than Sibutramine HCl.
2.How do Dobutramine Powder work?
This product is acting on the central obesity treatment drug. Mainly through its amine (amine and Primary Amine) metabolites generated effects, the main mechanism for the inhibition of norepinephrine and 5 – hydroxytryptamine and dopamine reuptake and enhanced sense of satiety, while norepinephrine, 5 – serotonin and dopamine release was observed.
(1)Dobutamine is a sympathomimetic drug used in the treatment of heart failure and cardiogenic shock.
(2)Dobutamine is used to treat acute but potentially reversible heart failure, such as which occurs during cardiac surgery or in cases of septic or cardiogenic shock, on the basis of its positive inotropic action.
(3)Dobutamine can be used in cases of congestive heart failure to increase cardiac output. It is indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of patients with cardiac decompensation due to depressed contractility, which could be the result of either organic heart disease or cardiac surgical procedures. It is not useful in ischemic heart disease because it increases heart rate and thus increases myocardial oxygen demand.
3.Dosage of Dobutramine Powder
Usage: used for diet and exercise can reduce and control weight obesity treatment. Recommended for body mass index (BMI) was 30 kg/m2, or was 28 kg/m2 at the same time with other risk factors such as diabetes, dyslipidemia in patients with obesity, etc. Note: BMI (kg/m2) = weight (kg) / height square (m2). East cloth QuMing action principle is equal to the west take Ming, but it relative sibutramine is testing a weight loss raw materials, additives and the matters needing attention and hydrochloric acid QuMing the same.
Usage and dosage: recommended dose for medicine every day 1, a 10 mg, and in the morning and breakfast alone taking or at the same time take. Such as weight loss is not obvious, 4 weeks after dose can be increased to 15 mg every day, if patients can’t tolerate 10 mg/day dose, can drop to 5 mg/day. Do not recommend using 15 mg/day above the dose.
It is mainly produced by the metabolites of amine (secondary amine and amine), the main mechanism was to inhibit the ingestion of norepinephrine, serotonin and dopamine and to increase satiety, but had no significant effect on norepinephrine, serotonin and dopamine release.
The oral absorption was rapid, the average dosage was 77%, the blood concentration reached the peak time of 1.2 hours, the oral clearance rate was 1750l/h and the half-life was 11 hours.
The liver’s cytochrome P450 (3A4) Isoenzyme was metabolized by the hepatic first-order activity as a bioactive metabolite of both M1 and M2, which had pharmacological metabolites M5 and M6.
The concentration of drug and its metabolites in plasma can reach the peak within 3-4 hours after taking medicine, the plasma concentration of M1 and M2 in 4 days is steady, and the concentration is twice times that of single dose. Usage dosage: Recommended dosage is 1 times a day, once 5-10mg. If the weight loss is not obvious after 2 weeks can be increased to daily 15-20mg dosage.
4.Comparing with Sibutramine HCL:
1). Sibutramine hydrochloride powder Names:
Sibutramine hydrochloride powder normally is called by Sibutramine hcl, Sibu, Meridia by the bodybuilders or UGL owners.
2).Sibutramine hydrochloride powder Usage:
Sibutramine hydrochloride is commonly used as an oral taken tablets or capsules, at 15mg/tab, 20mg/tab, 30mg/tab. For some south Asian factories, they use it to do fat loss coffee or tea.
Sibutramine HCL powder has molecular formula C17H27C12N and it is white powder in appearance. It is 99% pure and very effective for weight loss. This assist in weight loss by altering neurotransmitters in the brain that are chemicals released by the brain for coordination among neurons. This drug blocks the neurotransmitters such as norepinephrine, dopamine and serotonin, that disturbs the neuronal coordination. This blockage helps in altering cholesterol metabolism resulting in weight loss.
This is only effective when a person takes the medicine with a low-calorie diet and usually exercise is suggested by the physician. One tablet of the suggested brand with above chemical formula is required per day. Usually, no side effects are observed but this is addictive, so person using this medicine should be cautious and try to not to rely entirely on this.
3). Warning on raw meridia hcl powder:
Substantially increases blood pressure and increases pulse in some users, particularly when initiated at higher dosages. Monitoring of blood pressure and pulse required prior to and at regular intervals during therapy. Consideration of decreased dosage or discontinuance recommended in patients with sustained increases in blood pressure or pulse rate.
Stop using sibutramine and call your doctor at once if you have a serious side effect such as:
fast, pounding, or uneven heartbeats;
new or worsening shortness of breath;
agitation, hallucinations, fever, tremor, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, dilated pupils;
very stiff (rigid) muscles, high fever, sweating, confusion, feeling like you might pass out.
Less serious side effects may include:
dry mouth, upset stomach;
changes in appetite;
constipation, stomach pain;
headache, back pain, joint pain;
feeling nervous, dizzy, or depressed;
flu symptoms, runny or stuffy nose, sore throat, cough;
warmth, redness, or tingly feeling under your skin;
trouble sleeping (insomnia); or
mild skin rash.
4).raw Sibutramine hydrochloride powder Further instructions:
(1). Mixed sweet potato leaves, lotus leaves, coffee powder and other plant extracts, such plant extracts are alkaline substances, with sibutramine hydrochloride mixed use, acid-base neutralization, reduce or lead to product weight loss effect instability.
(2). Direct use of sibutramine hydrochloride, each capsule content 10-30mg.
(3). From the pharmacy, it is recommended that the use of grape sugar and sibutramine hydrochloride mixed capsules, recommended dose 15mg.
Rapidly absorbed following oral administration; undergoes extensive first-pass metabolism in the liver to form mono- and di-desmethyl active metabolites (M1, a secondary amine, and M2, a primary amine, respectively). Absolute bioavailability is unknown, but mass balance studies indicate that at least 77% of a single oral dose is absorbed.
Food increases the time to peak plasma concentration and decreases the peak plasma concentrations of the desmethyl metabolites by about 3 hours and 30%, respectively, but does not affect the area under the plasma concentration–time curves (AUCs) of the desmethyl metabolites.
meridia hcl powder should not be prescribed until organic causes for obesity, such as untreated hypothyroidism, have been ruled out.
In sibutramine obesity trials of 6 months or longer, the patients who lost at least 1.8 kg (4 pounds) of body weight during the first 4 weeks of treatment were much more likely than the patients who lost less than this to subsequently lose at least 5% of their initial body weight at a given dose. If a patient does not lose at least 1.8 kg (4 pounds) in the first 4 weeks of sibutramine treatment, therapy should be re-evaluated and sibutramine dosage should be increased, or sibutramine use should be discontinued.
The abuse potential of sibutramine was found to be very low in rat and human studies designed to assess potential for abuse as a psychostimulant and in rat studies designed to assess potential for abuse as an hallucinogen.
5). meridia hcl powder :
Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order(Within 1kg)can be sent out in 3 workingdays after payment.
For the sibutramine HCL from AASraw, there are two kinds of raw powder provided.
Brown color powder can’t be detected by HPLC or some other methods.
White powder can’t be detected by HPLC or some other methods.
White crystalline powder can be detected by HPLC or some other methods.
6). meridia hcl Powder Recipes:
To inquiry our Customer Representitive(CSR) for details, for your reference.
For capsule: 20-40mg of sibutramine hcl raw powder is commonly found in the market.
For tablets: To mix with some vitamin or Senna to make the powder much effective. For details, please consult our CSR.
For slim Tea/Coffee: The non-detected sibutramine hcl raw powder is needed, which can guarantee the mixed slim goods no sibutramine hcl found. For the dosage, normally at 28-35mg.
For injection: It is heard in some underground labs the sibutramine hcl liquid was made at 1.0-4.0mg/ml.
5.Dobutramine Powder Function and Side effects:
Babutramine, with the same mechanism of sibutramine, is an orally administered agent for treatment of obesity. It mainly becomes effective through the metabolin of its amine ?secondary amine and primary amine?, its main mechanism is increasing the feeling of satiation by controlling the reingestion of noradrenalin, serotonin 5-HT and dopamine, however, it has no evident effect on the release of noradrenalin, serotonin 5-HT and dopamine. Study also shows that, this product and its amine activated metabolin have no evident prohibiting effects, such as choline-resisting, histamine-resisting, and monoamine oxidase. The weight-losing effect of Babutramine is more excellent than sibutramine, its side effect is smaller, and it can’t be detected.Adaptive disease: It is used to treat adiposity that the weight can’t be controlled by diet-controlling and sports.
1.The one who takes monoamine oxidase inhibitor.
2.the one who takes anorectic medicines which works in nervus centralis
3.The one who suffers from hysteric apepsia
4.The one who is allergic to this product.
5.high blood pressure suffer whose blood pressure is hard to control and can’t be controlled
6.The one who suffers from coronary heart disease, heart failure, arrhythmia and apoplexy.
7.The one who suffers from serious live and kidney disease.
6.Related products Specification:
Appearance:White Crystalline powder
Solubility: Freely soluble in methanol
Heavy Metals:10 PPM Max
Each Impurity:0.2% Max
Total Impurities:0.4% Max
Residue on ignition:0.1% Max
TLC:Only one spot
Dobutramine Powder HCl
Weight-reduction pharmaceuticals which is better than Sibutramine Hcl
Weight-reduction pharmaceuticals which is better than Sibutramine Hcl
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Distributors/Traders List included in Dobutramine Powder Market
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I bought from Ali Baba bought 50 grams and Olistatit, which was packed in capsules. But Olistat is tasted not like the Indian one and Inningman, which burn fat, just defecate unobstructed point. The Dobutramine Powder is with little reaction. Even though I double the dosage. Except the no weight loss, I got fatter. Is it because of antibodies? How does it without any effect?
Generic name: Dobutramine Powder
English name: Dobutramine Powder
Packing specification: 5kg
Character: white or slightly white powder This product is a central obesity treatment drug. It is mainly produced by the metabolites of amine (secondary amine and amine), the main mechanism was to inhibit the ingestion of norepinephrine, serotonin and dopamine and to increase satiety, but had no significant effect on norepinephrine, serotonin and dopamine release. The pharmacokinetics was absorbed rapidly, the average dose was at least 77%, the blood concentration reached the peak time of 1.2 hours, the oral clearance rate was 1750l/h and the half-life was 11 hours. The liver’s cytochrome P450 (3A4) Isoenzyme was metabolized by the hepatic first-order activity as a bioactive metabolite of both M1 and M2, which had pharmacological metabolites M5 and M6. The concentration of drug and its metabolites in plasma can reach the peak within 3-4 hours after taking medicine, the plasma concentration of M1 and M2 in 4 days is steady, and the concentration is twice times that of single dose.
①Renal insufficiency patient
②Hypertension, diabetic person usage dosage: Recommended dosage is to take 1 times a day, once 5-10mg. If the weight loss is not obvious after 2 weeks can be increased to daily 15-20mg dosage.
9.Buy Genius Dobutramine Raw Powder from AASraw
Our provided Doibutramine/ Dobutramine Powder is a centrally acting drug treatment of obesity. Mainly through its amine (secondary amines and primary amines) metabolites have an effect, the main mechanism for the inhibition of norepinephrine and 5 – serotonin and dopamine reuptake and enhance satiety, and norepinephrine, 5 – serotonin and dopamine release no significant effect. Clients can avail this Doibutramine/ Dobutramine Powder at industry leading prices from us.
Dobutramine Powder is a therapeutic drug for obesity in the central nervous center, which is developed on the basis of the Sibutramine. The Dobutramine Powder functional principle is similar with Sibutramine. But compared to the Sibutramine, Dobutramine Powder’s weight loss effect is more prominent and less side effect, and more, it cannot be detected. After all, it is a new type of weight loss material.
Character: Dobutramine Powder is a product developed on the basis of the Sibutramine, which is white or grayish powder, insoluble in water and soluble in ethanol. More questions for sibutramine, please consult us.
1.To contact us by our email inquiry system,or online skype customer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.