Everything about Fosaprepitant Dimeglumine powder
Fosaprepitant dimeglumine(EMEND) powder video
I.Fosaprepitant dimeglumine(EMEND) powder basic Characters:
|Name:||Fosaprepitant dimeglumine(EMEND) powder|
|Storage Temp:||-20°C Freezer|
|Color:||white to off-white amorphous powder|
Fosaprepitant Dimeglumine is used for Nausea and vomiting caused by cancer drug treatment and other conditions. This salt may also be used for purposes not listed in this medication guide.
Intravenous fosaprepitant dimeglumine (Emend® for injection, IVEmend®; henceforth referred to as fosaprepitant) is a prodrug of and is rapidly converted to the antiemetic aprepitant, and is approved in several countries worldwide (as part of an antiemetic regimen) for the prevention of nausea and vomiting associated with highly and moderately emetogenic chemotherapy (HEC and MEC). This narrative review discusses the pharmacological properties of intravenous fosaprepitant and its clinical efficacy and tolerability in the prevention of nausea and vomiting associated with HEC and MEC. In large, randomized phase III clinical trials, a single intravenous dose of fosaprepitant 150 mg was an effective and generally well tolerated addition to an antiemetic regimen that included dexamethasone and a serotonin 5-HT3 receptor antagonist in adult cancer patients undergoing treatment with HEC or MEC. It was also noninferior to an oral aprepitant-based regimen in adult cancer patients undergoing HEC treatment. The tolerability profile of a fosaprepitant-based regimen was typical of that in patients receiving emetogenic chemotherapy, and adverse events were generally consistent with those observed with an aprepitant-based regimen. Fosaprepitant provides a useful addition to antiemetic therapy regimens.
Name: Fosaprepitant dimeglumine(EMEND) powder
Molecular Formula: C23H22F7N4O6P.2C7H17NO5
Molecular Weight: 1004.83
Melt Point: 242-247°C
Storage Temp: -20°C Freezer
Color: white to off-white amorphous powder
115 mg injection (3-day dosing regimen)
Highly emetogenic cancer chemotherapy Adults
IV Fosaprepitant 115 mg on day 1 only as an infusion over 15 minutes, 30 minutes prior to chemotherapy. Aprepitant 80 mg orally should be administered on days 2 and 3. Aprepitant 125 mg orally may be substituted for fosaprepitant 115 mg IV on day 1. Administer in conjunction with a corticosteroid (dexamethasone 12 mg orally 30 minutes prior to chemotherapy on day 1 and 8 mg orally in the morning on days 2 through 4) and a 5-HT 3 antagonist (ondansetron 32 mg IV 30 minutes prior to chemotherapy on day 1).
Moderately emetogenic cancer chemotherapy Adults
IV Fosaprepitant 115 mg on day 1 only as an infusion over 15 minutes, 30 minutes prior to chemotherapy. Aprepitant 125 mg orally may be substituted for fosaprepitant 115 mg IV on day 1. Aprepitant 80 mg orally should be administered on days 2 and 3. Administer in conjunction with a corticosteroid (dexamethasone 12 mg orally 30 minutes prior to chemotherapy on day 1) and a 5-HT 3 antagonist (ondansetron 8 mg orally 30 to 60 minutes prior to chemotherapy and 8 h after the first dose on day 1).150 mg injection (single-dose regimen)
Highly emetogenic cancer chemotherapy Adults
IV Fosaprepitant 150 mg on day 1 only as an infusion over 20 to 30 minutes, 30 minutes prior to chemotherapy. Administer in conjunction with a corticosteroid (dexamethasone 12 mg orally 30 minutes prior to chemotherapy on day 1, 8 mg orally in the morning on day 2, and 8 mg orally twice daily on days 3 and 4) and a 5-HT 3 antagonist (ondansetron 32 mg IV 30 minutes prior to chemotherapy on day 1).
(1)Missing a dose
In case you miss a dose, use it as soon as you notice. If it is close to the time of your next dose, skip the missed dose and resume your dosing schedule. Do not use extra dose to make up for a missed dose. If you are regularly missing doses, consider setting an alarm or asking a family member to remind you. Please consult your doctor to discuss changes in your dosing schedule or a new schedule to make up for missed doses, if you have missed too many doses recently.
(2)Overdosage of Fosaprepitant Dimeglumine
- Do not use more than prescribed dose. Taking more medication will not improve your symptoms; rather they may cause poisoning or serious side-effects. If you suspect that you or anyone else who may have overdosed of Fosaprepitant Dimeglumine, please go to the emergency department of the closest hospital or nursing home. Bring a medicine box, container, or label with you to help doctors with necessary information.
- Do not give your medicines to other people even if you know that they have the same condition or it seems that they may have similar conditions. This may lead to overdosage.
- Please consult your physician or pharmacist or product package for more information.
(3)Storage of Fosaprepitant Dimeglumine
- Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.
- Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Fosaprepitant Dimeglumine.
(4)Expired Fosaprepitant Dimeglumine
- Taking a single dose of expired Fosaprepitant Dimeglumine is unlikely to produce an adverse event. However, please discuss with your primary health provider or pharmacist for proper advice or if you feel unwell or sick.
- Expired drug may become ineffective in treating your prescribed conditions. To be on the safe side, it is important not to use expired drug. If you have a chronic illness that requires taking medicine constantly such as heart condition, seizures, and life-threatening allergies, you are much safer keeping in touch with your primary health care provider so that you can have a fresh supply of unexpired medications.
Detailed information related to Fosaprepitant Dimeglumine’s uses, side-effects, reviews, questions, interactions, and precautions is as follows:
Fosaprepitant Dimeglumine is used for the treatment, control, prevention, & improvement of the following diseases, conditions and symptoms:
Nausea and vomiting caused by cancer drug treatment
Fosaprepitant Dimeglumine may also be used for purposes not listed here.
The following is a list of possible side-effects that may occur in medicines that contain Fosaprepitant Dimeglumine. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.
- Peripheral neuropathy
- Urinary tract infection
- Pain in extremity
Before using Fosaprepitant Dimeglumine, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counseling points are listed below.
- Breast feeding
- Planning to have baby
If you use other drugs or over the counter products at the same time, the effects of Fosaprepitant Dimeglumine may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Fosaprepitant Dimeglumine may interact with the following drugs and products:
- Hormonal Contraceptives
- Is Fosaprepitant Dimeglumine safe to consume or apply when pregnant?
Please consult with your doctor for case-specific recommendations.
- Is Fosaprepitant Dimeglumine safe while breastfeeding?
Please discuss the risks and benefits with your doctor.
- Is it safe to drive or operate heavy machinery when consuming?
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Fosaprepitant Dimeglumine medicine then it may not be safe to drive a vehicle or operate heavy machinery. One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol intensifies drowsiness side-effects. Please check for these effects on your body when using Fosaprepitant Dimeglumine. Always consult with your doctor for recommendations specific to your body and health conditions.
- Is this medicine or product addictive or habit forming?
Most medicines don’t come with a potential for addiction or abuse. Usually, government’s categorizes medicines that can be addictive as controlled substances. Examples include schedule H or X in India and schedule II-V in the US. Please consult the product package to make sure that the medicine does not belong to such special categorizations of medicines. Lastly, do not self-medicate and increase your body’s dependence to medicines without the advice of a doctor.
- Can it be stopped immediately or do I have to slowly ween off consumption?
Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. Please consult with your doctor for recommendations specific to your body, health and other medications that you may be using.