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Isotretinoin is an ultra-effective acne treatment. Here, you’ll see the isotretinoin reviews,isotretinoin uses, isotretinoin side effects and other information about the medicine, including the dosage and the precaution measures.

 

Raw Isotretinoin (Accutane) for acne Treating Acne with Isotretinoin

 

What is Isotretinoin (Accutane)?

Are you in search of raw isotretinoin (Isotretinoin 4759-48-2)? Well, in case you are not familiar with it, Isotretinoin is a strong oral prescription drug. About isotretinoin uses, the medicine is used for the treatment and prevention of severe, disfiguring nodular acne or cystic acne.

When it comes to Isotretioin chemical properties, raw isotretinoin is basically 13-cis-retinoic acid. It comes as a yellow to orange sparkling powder and has a molecular weight of 300.44. It’s associated with retinoic acid as well as retinol (vitamin A).

What is cystic acne? 

 

Perhaps you are wondering what is cystic acne.  A cystic acne is a severe form of acne which results from blocked skin pores, causing an infection and inflammation. Many people, approximately 80 percent of those aged between 11 and 30 years suffer from acne, but only a small fraction of them have cystic acne, which is more severe than the usual acne.

An acne cyst is usually larger and more inflamed than a regular pimple and might not go away even after you take some treatment for acne. A cystic pimple can be painful and mostly leaves behind a deep scar.

 

Maybe your acne continues to proliferate despite your countless efforts to get rid of it.  You don’t need to look for proliferation synonym. The term simply means a rapid increase in the amount of something, in this case, acne. So, proliferation synonym is multiplication, spread, or escalation.

Now, that aside.

In case you have tried all other medical methods such as oral antibiotics and various topical medications to treat a cystic pimple or acne cyst, but in vain, Isotretinoin will most likely be the ultimate solution. Besides, the drug can also be used as a treatment for other skin conditions, depending on the doctor’s recommendation.

Isotretinoin Brand Name

Isotretinoin is a retinoid drug, a product of a synthetic vitamin A. it is also known by its brand names:

Absorica,

Accutane,

Amnesteem,

Claravis,

Myorisan,

Sotret

Zenatane.

Also, the drug is available in various generic versions.

How does Isotretinoin Work?

Besides, Isotretinoin uses, perhaps you are wondering, “how does Accutane work?” Why is it is so powerful that it can do what some antibiotics and topical medications can’t?

Well, here’s an explanation of the answer to the question ‘how does Accutane work?’

Similarly to other retinoid drugs, Isotretinoin functions by changing your DNA transcription.  The effect of the alteration is the reduction of the size as well as the production of the sebaceous glands.

When you take Isotretinoin, it shrinks your skin’s sebaceous glands which are responsible for the sebum production. Sebum is an oily substance and its excessive production can lead to various skin issues such as acne.

The excessive sebum blocks the sebaceous glands, preventing the skin oil from flowing out. This causes the accumulation of the oil beneath the skin. The bacteria which cause cystic acne (acne vulgaris) tend to thrive in such condition as sebum is their food.

When Acne vulgaris feed on the sebum in your skin, they produce waste products as well as fatty acids. The excreta and the acids irritate the sebaceous glands and make them get inflamed. Skin spots also occur as a result.

So, when Isotretinoin shrinks the sebaceous glands, the amount of their sebum production reduces.  As a result, the clogging of cores by the sebum is minimized as well. Considering that pimples, or rather acne, mostly occurs as a result of skin pore clogging by sebum, the effect of the medication controls them.

It prevents the blockage of the sebaceous glands and so, there is minimal likelihood for bacteria to thrive in the skin. The drug also reduces skin inflammation.   Besides, the drug also reduces the stickiness of the cells that have been shed off into the sebaceous glands. This reduces their capability to form blackheads and whiteheads.

Raw Isotretinoin for acne Treatment

Isotretinoin 4759-48-2 is undoubtedly the ultimate acne treatment, particularly for severe cases where the use of antibiotics and topical acne medications has been rendered futile. One awesome thing about Isotretinoin as a treatment for acne is that you might have to use it for just a short span of time, perhaps 16 to 20 weeks to say goodbye to your pimples, no matter how severe they are.

Nevertheless, your dermatologist may recommend a second course of treatment of a similar duration to for the full clearance of your acne. This is unlike the majority of other acne drugs which you might need to use continuously for an extended period or even forever to keep acne at bay.

Although it’s rare for you to get pimples again once you are done with Isotretinoin course of treatment, your skin care specialist may advise you to transition to a topical acne medication for the maintenance of your new, acne-free skin.

 

Raw Isotretinoin (Accutane) for acne Treating Acne with Isotretinoin

 

How long does take for one to start seeing Accutane results?

This might take you by surprise if have never heard about it because it is the opposite of your expectations; your pimples might become worse upon starting to take Isotretinoin. Hey! Don’t freak out yet!

However, you’ll start to see Accutane results within   7 to 10 days of your treatment course. Your pimple will start diminishing gradually within the period.

Mostly, full or near-full acne clearing occurs within 16 to 24 weeks of the treatment course. Once you are through with the course, you’ll highly possibly remain acne-free for a very long period.

A repeat course is only recommended in cases whereby a definite relapse is noticed after the treatment course. Nevertheless, a repeat course should only be started at least 8 weeks after the last day of the previous (initial) course. This is because acne is likely to improve within that period after the initial course.

How to use Isotretinoin

Accutane (Isotretinoin) is available in in oral 10-mg, 20-mg as well as 40-mg soft gelatin capsules. The elements contained in every capsule of this drug include  beeswax, butylated hydroxyanisole, soybean oil, edetate disodium, hydrogenated vegetable oil as well as hydrogenated soybean oil flakes.

Each of isotretinoin 10mg, isotretinoin 20mg and isotretinoin 40mg capsule have different dye systems. Isotretinoin 10mg features iron oxide (red) and titanium dioxide, 20mg has FD&C Red No. 3, FD and C Blue No. 1, and titanium dioxide while 40mg has FD&C Yellow No. 6, D&C Yellow No. 10, and titanium dioxide dye systems.

In layman’s language isotretinoin 10mg comes in light pink color, 20 mg in maroon, while 40 mg are yellow.

Isotretinoin dosage

Isotretinoin dosage is different for different patients. Therefore, it is important that you follow your doctor’s prescription of the usage instructions on its label.

The rule of thumb is that your initial isotretinoin dose is dependent on your body weight, the medical issue for which you are using the drug as well as the strength of the medicine.

For adults and kids who are at least 12 years old, the average daily dose is 0.5 to 1 milligram (mg) per kilogram (kg) of body weight. Whichever the dose that your doctor recommends, should be taken with a meal every time.

Isotretinoin dose is taken as two divided doses and a qualified patient should take it for 15 to 20 weeks. For kids who are younger than 12 years of age, their dosage must be determined by their doctor.

If your doctor prescribes you a 0.5 mg/kg/day isotretinoin dose, that doesn’t necessarily mean that you’ll be using that dose throughout the treatment course. Depending on your response to the drug, especially as far as the clearing of your cystic acne and the appearance of clinical side effects are concerned, your doctor can adjust the dose.

Here are the average Isotretinoin 4759-48-2 dosages according to body weight

 

Body Weight

Total mg/day
Kgs pounds 0.5 mg per kg 1 mg per kg 2 mg per kg*
40 88 20 40 80
50 110 25 50 100
60 132 30 60 120
70 154 35 70 140
80 176 40 80 160
90 198 45 90 180
100 220 50 100 200

 

However, there’s a special exception to the dose recommendation range. Adults with severe cystic acne causing scaring or nodular acne mainly manifested on their backs may need adjustment by a maximum of 2.0 mg/kg/day, depending on their tolerance to myorisan (Isotretinion).

Isotretinoin usage

Accutane (isotretinoin) should be taken with food. It’s advisable that you take every dose of the drug immediately after a meal or snack to ensure maximum effectiveness of the medicine.

 

Failure to take the drug with food will reduce its absorption by the body significantly. Therefore, before your doctor adjusts your dose upwards to increase the effectiveness of the drug, you’ll be questioned about your compliance with food instructions.

Also, you should swallow Accutane capsule whole without crushing, breaking, chewing or sucking it. Besides, you are supposed to swallow it with a full glass of water.

 

Raw Isotretinoin (Accutane) for acne Treating Acne with Isotretinoin

A single course of Isotretinion has been proved to result in full or persistent remission of cystic acne. However, as earlier mentioned, in case your dermatologist finds it necessary for you to have a second course of treatment, it should start as from the eighth week after the day the first course ended.

In a study to analyze the effectiveness of the isotretinoin dosages, it was established that all of them offered initial clearing of acne. However, retreatment with the lower dosages was found to be safer.

What to avoid while taking isotretinoin

AASRAW Call IconGetting pregnant while taking the medication and within one month after the end of the treatment course.

AASRAW Call IconBreastfeeding during the treatment course and within one month after the course. It is suspected that the drug can pass through your milk and possibly harm your baby but there’s no scientific evidence to back up the suspicion.

AASRAW Call IconDonating blood while taking the medication and within one month after the end of the treatment course. If a pregnant woman gets your donated blood, her baby might be at risk of the side effects of the medication.

AASRAW Call IconTaking other medications or herbal products containing Accutane (isotretinoin) unless you have your doctor’s approval.

AASRAW Call IconDriving at night in case your night vision has been affected by Accutane (isotretinoin).

AASRAW Call IconGetting a cosmetic procedure for skin smoothening, while taking Accutane and six months after the course of the treatment. The procedures include waxing, dermabrasion, and lasers. The medication may make you more vulnerable to scarring resulting from these procedures.

AASRAW Call IconHaving direct sunlight and ultraviolet light exposure. The medication can increase your skin’s sensitivity to these lights.

AASRAW Call IconSharing the drug with other people. As mentioned earlier, the drug should be taken upon a doctor’s prescription.

Missed Accutane (isotretinoin) dose 

In case you miss your myorisan   dose, you should take it as soon as you can. Nevertheless, you’ve remembered about it when it is almost time for your next dose, just do away with the missed dose and resume your regular dosing schedule.  Take the next dose at the regular time. Don’t take two doses at the same time or too close to each other.

Special prescribing requirements 

Due to the possible severe side effects of Accutane (isotretinoin), the marketing of the drug is exclusively done through a special limited distribution program called iPLEDGE™. The program is approved by Food and Drug Administration.

The prescribers of the medicine must be registered and activated with this program- iPLEDGE.  Besides, the drug is exclusively for patients who have been registered with the program and ascertained to have comprehensively met the requirements of the program.

 So, what’s all about iPledge program?

The main aim of iPledge program is to make sure that only the qualified people take the medication and the possible side effects are kept as minimal as possible through adherence to the drug’s prescription and strict observance of the cautionary measures. Things involved in the program include monthly pregnancy tests and birth control. Talk to your doctor to know more about the program.

Pregnancy tests

Female patients who can get pregnant are supposed to undergo two urine or serum pregnancy tests with a minimum sensitivity of 25 mIU/mL. Their results for both tests must be negative for them to receive their first Accutane (isotretinoin) prescription.

The initial test is gotten by the specialist prescribing Accutane (isotretinoin) upon establishing that the acne is qualified for Accutane treatment. The second test is primarily done to confirm the results of the first test. It is supposed to be performed in a laboratory with CLIA certification.  The period between the two test shouldn’t be less than 19 days.

In case you are a female cystic acne patient with a regular menstrual cycle, the second pregnancy test should be performed within the first five days of the menstrual period which is right preceding the possible start of the of Accutane (isotretinoin) treatment course. Besides, the test should be done after you have used two types of contraception for 30 days.

If your menstrual cycle is irregular, or are on a birth control technique that prevents withdrawal bleeding, the second test should be performed within a period that immediately precedes the start of Accutane (isotretinoin) course of treatment.  Just as with a woman with a regular menstrual cycle, this test should also be done after you have used two types of contraception for 30 days.

You need to understand and strictly follow all the requirements of the iPledge program. Otherwise, you won’t qualify to get the drug or another prescription of the medication.

We previously saw that there are numerous isotretinoin brands. Another thing you ought to know is that different isotretinoin brands work differently. In as such, capsules of a certain brand of the drug shouldn’t be substituted with any other form of isotretinoin.

For instance, you shouldn’t substitute Accutane capsules with Absorica capsules. Therefore, in case you refill your isotretinoin (Accutane) and you find that it seems different from the initial one, seek clarification from your pharmacist.

What are the side effects of Accutane    

Perhaps at this point you are wondering, “is Accutane safe?” well; in as much as the drug is an ultra-effective treatment for acne, just like any medicine, it can result in some side effects. But there’s nothing to worry about Isotretinoin side effects especially if you follow the prescriptions to the letter and strictly observe the precautions.

We are going to see more about the precautions (the dos and the don’ts) here later on.

Another thing that you are supposed to bear in mind about the side effects of Accutane is that not everyone who takes the medication experiences them (the undesired effects). Besides, the undesired effects normally go away when you stop taking the medication.

While some Accutane side effects are common and less severe, others are rare and more severe.  Let’s first look at the common side effects of Accutane.

Common Isotretinoin side effects

The common Isotretinoin side effects include:

  • Skin dryness, flaking and itchiness
  • skin peeling, particularly on the palms and soles
  • Mouth, nose, and eye dryness
  • Chapped lips
  • Nosebleeds
  • Hair thinning
  • Photosensitivity
  • Reduced night vision
  • Fatigue (extreme tiredness
  • Red, cracked and sore lips

Less common side effects of Accutane

Although the following side effects can occur, their occurrences are less common. In fact, only less than 0.001% of the people who take the drug experience these serious effects.  These effects include:

  • Headache
  • Painful bones and joints
  • Chest and abdominal pain
  • Nausea
  • Vomiting
  • Pain or difficulty while swallowing something
  • Diarrhea
  • Rectal bleeding

Dry skin and lips are very common side effects. For safety, do not have any waxing, dermabrasion, or laser skin treatment while you’re taking isotretinoin for acne and for at least 6 months after you stop, as this could cause scarring or skin irritation.

  • Birth defects

Many people ask, “Is Accutane safe for pregnant women?” The answer is NO; it isn’t safe at all for pregnant women.

Pregnant women are highly discouraged to use Accutane for acne or cystic acne treatment or for any purpose whatsoever. Also, women who are likely to get pregnant during the course of the Roaccutane treatment shouldn’t use the drug.

The reason for that caution is because the effect of Isotretinoin mechanism of action, irrespective of the Isotretinoin dosage, can affect the fetus, causing birth defects. Some of the body organs/parts of the foetus that can be affected by abnormalities include the face, brain, heart ears, eyes as well as thymus and parathyroid glands.

Also, a pregnant woman who takes this medication is at high risk of spontaneous abortion or premature birth.

If a woman who’s taking Accutane (Isotretinoin) conceives (gets pregnant), she should stop using the drug immediately and visit an Obstetrician-Gynecologist who’s experienced with reproductive toxicity.

Although there’s no accurate way in which the specialist can establish if the unborn child has been affected by Isotretinoin mechanism of action, he/she can conduct an evaluation to establish the possibility of the same. Besides, the mother will get counseling to enable her cope with the resulting anxiety and the possible negative outcomes.

 

Raw Isotretinoin (Accutane) for acne Treating Acne with Isotretinoin

 

Does Isotretinoin also cause depression? 

Depression is the most contentious effect of Isotretinoin. There are some reports indicating that some people taking the drug experience depression. However, there’s no scientific evidence linking roaccutane with suicide.

There’s no one who can really explain how the drug is likely to cause depression. However, some scientists believe that the medication is likely to disrupt the production of serotonin as well as the manner in which it is utilized by the body.

Possibly this sounds scary but there’s no cause for alarm. Reason? The majority of the people who use Isotretinoin experience any mental issue. In fact, there no absolute evidence linking the use of Isotretinoin with depression. Better still; some studies have cast doubt on the possible link between the two.

Nevertheless, as a precautionary measure, in case you have a history of depression or any other form of mental illness, ensure that you bring it to the attention of your health specialist before you start taking Isotretinoin. Also, in case you develop depression symptoms have suicidal thoughts or psychosis while taking Isotretinoin; don’t hesitate to let your healthcare service provider know about it.

How to deal with the side effects of Accutane

There are of the things that you can do to address the respective Isotretinoin side effects:

Isotretinoin  side effect How to cope with it
 dry skin or lips  Apply a moisturizer (preferably oil-free face moisturizer   for sensitive skin)  and a lip balm on your lips regularly

Reduce your shower time to less than 2 minutes and use   lukewarm water instead of hot

 Increased skin sensitivity to light  Stay away from bright sun and apply a high factor, oil-   free sun cream on your skin even when it’s cloudy.  Avoid   using a sunlamp or sunbeds
 Dry eyes  Request your eye specialist to recommend to you some   eye drops. In case you wear contact lenses and they feel   uncomfortable while taking Isotretinoin, you can   substitute them with glasses for the period you’ll be   taking the medication.
 Dry mouth/throat  Chew sugarless gum or sweets.
 Headaches

Joint pain

Muscle pain

 Request your pharmacist to recommend you a pain-   relieving drug.

 Avoid intense exercises as they may worsen the pain

 

 Is Isotretinoin Safe to Use?

The answer to whether Isotretinoin safe to use can be either yes or no. It depends on an individual.

First, as earlier mentioned, there are specific conditions (for instance, pregnant women or those that are likely to conceive) that make some people unfit to use the drug. If you have these conditions, it won’t be safe for you to use Isotretinoin

Besides, Isotretinoin is exclusively meant to be taken by people with severe cystic acne/nodular acne or widespread acne of the back or body that won’t clear even after taking retinol for acne or any other treatment for acne. In case your acne is mild, your dermatologist will most likely prescribe you other mild products with vitamin A for acne or any other medically proved treatment for acne.

How to buy Accutane (isotretinoin) online

If are a manufacturer, patient or pharmacist, have met all the requirements of iPledge program and need to buy isotretinoin, you can simply get it hassle-free online. However, remember there’s a caveat when it comes to the marketing of this drug; it should only be sold by iPledge-approved suppliers and pharmacists.

For you to be legally allowed to distribute or sell isotretinoin, you should first register with iPLEDGE and also agree to fulfill all the respective requirements set by the program for isotretinoin product distribution.

Considering the requirements, aasraw.com is the best, most convenient and place where you can buy isotretinoin effortlessly.  We sell genuine raw isotretinoin and isotretinoin capsules to wholesalers and pharmacists at competitive prices.

How are you supposed to store Accutane (isotretinoin)?

Accutane (isotretinoin) should be stored in a sealed container at room temperature (59° to 86°F, 15° to 30°C). The place that you keep this drug should be away from heat and direct light and should be moisture-free. Besides, the drug shouldn’t be frozen and should be kept out of children’s reach.

Don’t keep this drug if it’s no longer needed or outdated. However, don’t just dispose using just any way; consult your healthcare specialist for proper disposal directions.

Isotretinoin Reviews

Let’s now see some Isotretinion reviews from some people who have used the medication.

Hannah White: “Can’t keep calm! Finally, I have managed to get an acne free face that I’ve been yearning for years. Since my adolescence 12 years ago, I had been battling with severe acne. I lost my self-esteem as a result.

I tried nearly all anti-acne products but none of them managed to get rid of the pimples. Last year, a friend advised me to try Isotretinoin which I did. I completed the treatment two months ago and I’m very happy with the results. My acne has cleared and the black spots are fading away too. I’d definitely recommend this drug to someone.”

Kelly: I can’t thank whoever came up with isotretinoin for acne. Were it not for the drug, I’d still be dealing with the severe cystic acne. I’d advise anyone out there who’s almost giving up on getting an effective cystic acne medication to visit their doctor and find out if it’s okay for them to use Isotretinoin (Accutane). This medicine indeed works wonders; I can confidently attest to that.

Juliana: “Although isotretinoin costed me an arm and a leg, I got maximum value for my money. In fact, I feel like I got more than what I paid for. I’m sure if I continued to use my usual medications, I’d have spent much more money, yet without getting the desired outcomes. I strongly recommend Accutane for acne that has beaten other products with vitamin A for acne. “

Emily Hanson: “wow! Couldn’t be happier with the isotretinoin mechanism of action and the results. After reading many isotretinoin reviews, I decided to visit a pharmacist to establish if the drug was suitable for me.

Upon seeing my acne treatment record, he confirmed that the acne could be treated using isotretinoin as it was severe and persisted for a long period despite various treatments. I started to see a significant improvement on my face within the first 10 weeks of the treatment course and by the 20th week, the acne had cleared completely.”

Billy Harts:  I am a licensed and iPledge-approved pharmacist with a drug located at Illinois. I started selling isotretinoin roughly one year ago and boy…! This drug is selling like a hotcake. Even with the iPledge requirements, my patients highly praise it. I’d like to thank aasraw.com for bringing it closer to me.

Salome Williams: “Don’t mind about isotretinoin cost; this drug is the real deal for cystic acne treatment. It’s been three years since the time I finished my isotretinoin treatment course and couldn’t be happier with the results. My acne has disappeared and I can now step out with confidence. “

Charlene B:  The effectiveness of this drug in the fight against severe acne is unrivaled. I had tried tens of acne treatment products and it’s only isotretinoin that managed to set me free from the nuisance. I’m extremely grateful for this super-drug.

Isotretinoin online

Isotretinoin is beyond any doubt an ultra-effective acne treatment. In case you have severe cystic acne or a patient with serious cystic pimples that don’t clear even after taking other acne medications, the drug is highly likely to be a viable treatment option. However, doctor’s advice is very crucial before one embarks on taking this medication. Also, the patient and the drug’s distributor must ensure that they meet all the respective requirements pertaining to the handling of the medicine.

 

References

  1. Wysowski, Diane K., Joslyn Swann, and Amarilys Vega. “Use of isotretinoin (Accutane) in the United States: rapid increase from 1992 through 2000.” Journal of the American Academy of Dermatology4 (2002): 505-509.
  2. Williams, H. C., Dellavalle, R. P., & Garner, S. (2012). Acne vulgaris. The Lancet, 379(9813), 361-372.
  3. Feldman, S., Careccia, R. E., Barham, K. L., & Hancox, J. (2004). Diagnosis and treatment of acne. American Family Physician, 69(9), 2123-2138.
  4. Barak, Y., Wohl, Y., Greenberg, Y., Dayan, Y. B., Friedman, T., Shoval, G., & Knobler, H. Y. (2005). Affective psychosis following Accutane (isotretinoin) treatment. International clinical psychopharmacology, 20(1), 39-41.
  5. Stern, R. S., Rosa, F., & Baum, C. (1984). Isotretinoin and pregnancy. Journal of the American Academy of Dermatology, 10(5), 851-854.
  6. Barnes, C. J., Eichenfield, L. F., Lee, J., & Cunningham, B. B. (2005). A practical approach for the use of oral isotretinoin for infantile acne. Pediatric dermatology, 22(2), 166-169.
  7. Kilcoyne, R. F., Cope, R., Cunningham, W., Nardella, F. A., Denman, S., Franz, T. J., & Hanifin, J. (1986). Minimal spinal hyperostosis with low-dose isotretinoin therapy. Investigative radiology, 21(1), 41-44.

 

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