The 7 Best Nootropics(Smart Drugs) in the market of Armodafinil

Amodafinil is a psychostimulant drug developed by Celphalon Pharmaceuticals and was approved by the FDA on June 15, 2007. Amodafinil is the (−)-( R )-enantiomer of the active ingredient in the racemic drug modafinil. Armodafinil is the isomer of the drug modafinil (Progivil)

 

Armodafinil powder, like modafinil, has three main uses:

• Promotes awakening in cases of excessive sleepiness and narcolepsy
• It is a drug used for the treatment of attention deficit in children and adults
• It is used in people who must do rotating shifts, since it allows to avoid the sleep that can produce these hour changes in the biological clock of the people.
• It is used by some students to improve concentration.
The Cephalon company also wants and plans to conduct studies with the aim of evaluating armodafinil (Nuvigil) for the treatment of other chronic conditions such as bipolar disorder , schizophrenia , as well as sleep and fatigue in conditions such as Parkinson’s and cancer.

 

Armodafinil Compound introduction

Armodafinil is an enantiomeric compound of eugeroidal modafinil (Provigil). It consists only of the (R) – (-) – enantiomer of racemic modafinil.

Trade name Nuvigil
Molecular formula: C 15 H 15 NO 2 S
CAS No.: 112111-43-0
Molecular weight: 273.35000
PSA: 79.37000
LogP: 3.57600
Exact quality: 273.008200

 

Physicochemical properties

Physical appearance : white solid
The Density: 1.283g/cm 3
The Boiling point: 559.1oC at 760mmHg
The Flash point: 292oC
The Melting point: 156-158oC
The Vapor pressure: 1.56E-12mmHg at 25 C
The Refractive index: 1.645

The drug is approved in the United States for the treatment of excessive daytime sleepiness in patients over the age of 18 years associated with obstructive sleep apnea syndrome (OSAS), narcolepsy, or a shift worker syndrome.

 

Simple description of the Armodafinil powder

The indication for armodafinil is similar to modafinil. The US FDA admits almodafinil as a treatment for narcolepsy , sleep apnea syndrome and shift work sleep disorder , Alzheimer’s , developmental disorders.

Amodafinil is L-mododafin and is the main active ingredient in modafinil. 200 mg of modafinil in the left-handed and right-handed modafinil each accounted for half, but the right-handed modafinil is consumed for 4 hours, the consumption is reduced, modafinil took 2 hours The effect is that the highest peak of blood is reached in 4 hours. At the highest peak, L-mododa accounts for 90%, and the right-handed attenuation only leaves 10%. After the fourth hour, Moda plays a major role. It is L-mododafin. The effect of amodafinil is very strong. If Moda tries to stay awake, then Amoda can focus and stay awake, focus more attention, and have very few side effects. Ultimately, it will replace modafinil. Amoda has three times the affinity for plasma proteins, so it can bind to plasma proteins more closely. Therefore, the concentration of amoda that enters the brain with blood is very high. Amoda’s affinity for the brain is three times that of Moda.

The half-life of amodafinil is 13-15 hours. The side effects are minimal.
Continuous administration of amodafinil, the concentration of drugs in the blood will continue to stack, because the old blood drug concentration has not been attenuated, the new drug has entered the blood, continuous taking amodafinil will delay the arrival of blood drug peak.

 

The 7 Best Nootropics(Smart Drugs) in the market of Armodafinil

 

Armodafinil Pharmacology

 

Mechanism of action

Armodafinil increases wakefulness in patients who suffer from excessive drowsiness. It exerts its effect by influencing certain neurotransmitter receptors and stimulates the sympathetic nervous system . The exact mechanism of action, as with Modafinil, is unknown. In vitro , neither a direct nor an indirect effect as α 1 -adrenoceptor – or dopamine receptor agonist could be detected. The ability of armodafinil to maintain wakefulness is similar to that of amphetamine , although it differs from it in its pharmacological profile.

 

Metabolism

The half-lives of the two enantiomers of the modafinil differ by a factor of 3 from each other. The pharmacokinetics of Armodafinil are dose-independent and linear in the 50 to 400 mg range. The drug is rapidly absorbed and metabolised in the liver to two major metabolites. Armodafinil and its metabolites are excreted predominantly via the kidneys. In patients with severe hepatic or renal insufficiency, the dose should be reduced.

 

Armodafinil Usage:

Armomafinil is an oral drug. On the market, as a rule, the specification is 50 mg, 150 mg, 200 mg, 250 mg. For people with mormalia, they should be conducted at 150-250 mcg per day.

The indication for armodafinil is similar to modafinil. The US FDA admits almodafinil as a treatment for narcolepsy , sleep apnea syndrome and shift work sleep disorder , Alzheimer’s , developmental disorders.

 

Interactions

Armodafinil powder is metabolised by cytochrome P450 3A4 and also inhibits certain subtypes of the cytochrome P450 enzyme family. There is a potential for interaction with many other drugs, which in turn either inhibit or metabolize the same cytochrome P450 subtypes. These include in particular oral contraceptives , drugs for the treatment of seizure disorders ( anticonvulsants ), anticoagulants ( anticoagulants ), antidepressants or the immunosuppressant cyclosporine.

 

Side effects

The most common side effects reported were: headache, nausea, dizziness, sleep disturbances. Armodafinil may cause mild allergic reactions such as rashes or hay fever. Severe allergic skin reactions, such as those observed with the racemic form Modafinil, including Stevens-Johnson syndrome , are not excluded and require immediate discontinuation of treatment.

 

Armomafinil V.S. Modafinil

1.Armodafinil and Modafinil are non-amphetamine drugs that promote wakefulness and help people withstand sleep apnea, narcolepsy or excessive drowsiness remain active. … Initially, Modafinil was used to treat narcolepsy and improve wakefulness

2. Armomafinil is available in the form of 50 mg / 150 mg / 200 mg / 250 mg. Modafinil is available only as 100/200 mg.

3. Armodafinil’s service life is 15 hours, whereas Modafinil powder is 12 hours. The effect of Armodafinil is 8 hours, whereas Modafinil lasts 6 to 12 hours.

4. Farmafinil reaches its peak concentration later, the reason for systemic accessibility is longer, and the duration is longer than Modafinil. In addition, if you take 150 mg of Armodafinil, 200 mg of Modafinil will be needed. Because of the long-term effectiveness, Armodafinil powder is considered the best of the two, although health professionals say that they are both similar, and the results are often the same.

 

Before use

To decide on the use of the medicine, the benefits of using it should be more than harmful, and you and your doctor should decide whether to use the medicine or not.

 

You should consider:

children

Adequate studies have not been conducted on the relationship between age and the effect of armodafinil on children younger than 17 years of age. The safety and efficacy of this drug has not yet been established.

Elderly

Although no studies have been conducted on the relationship between age and the effect of armodafinil on older people, problems related to aging are not expected to limit the feasibility of using armodafinil on older people. However, elderly patients may have a slower removal of this drug from the body, which may require dose adjustment for patients receiving armodaphine.

 

Pregnancy and breastfeeding

Pregnancy

The classification of armodafinyl in pregnancy is (C). Animal studies have shown a negative effect and there are no adequate studies on human pregnancy. There are no animal studies and there are no adequate studies on human pregnancy.

Breast Feeding

Be careful, it is not known whether this drug is excreted in human breast milk.

 

Interactions and drug interactions

Although some medications should not be used side by side permanently , in other cases two different drugs can be used together even if they have a drug interaction . And in this case , your doctor forced to change the dose , or other precautions that may be necessary. When taking this medicine , it is important that your doctor knows if you are taking any of the medications listed below . The following interactions were selected on the basis of their importance Potential , which is not necessarily all-inclusive.

 

Drugs that interact with Armodafinil powder

Other interactions

Some medications should not be used in or around the time of eating or eating certain types of food because the interaction between medication and certain types of food may occur. Use of alcohol or tobacco may also lead to drug interactions. Discuss with the doctor as the use of this medicine with food or alcohol , or tobacco.

Other medical problems

The presence of other medical problems may affect the use of this medicine:

Depression or having a history of it, or high blood pressure, obsession, or psychosis: use the medication with caution. These conditions may become worse.

Left ventricular hypertrophy , or mitral valve fall: should not be used in patients with these conditions.

Liver diseases (severe): used with caution. The effects of the drug can increase due to its slow removal from the body.

Proper use

Take this medicine only as instructed by your doctor. Do not increase the dosage of the drug, and do not increase the number of times the drug is taken, and do not use it for longer than the doctor has decided.
This medicine comes with a Patient Information Bulletin (Internal Bulletin). It is very important that you read and understand this information. Be sure to ask your doctor if you have any questions.
If you suffer from sleep apnea and use continuous positive airway pressure at night, continue to use this device with medication.
Take this medicine at the same time each day. Do not change the timing of taking the medicine without talking to your doctor first.
You can take this medicine with or without food .

The side effects

Along with the therapeutic effects of the drug, this drug may cause some undesirable effects. Although not all of these side effects may occur, but if you do, you need medical attention.

Consult your doctor immediately if any of the following side effects have occurred to you:

Less common

Blisters, burning, flaking, dryness, or skin loss
Itching, numbness, or tingling sensation
breathing difficulties
Speed ​​or irregular heartbeat
Fever
frequent urination
Severe headache with palpitations
Increase the amount of urination
Itching, or severe redness, or wrench, or swollen skin
Skin rash
A tremor in the legs, arms, hands or feet
Shortness of breath

 

Precautions

It is very important that your doctor check your progress with the medication on regular visits to make sure that the drug is working properly and to verify that there are no undesirable effects.

This medication does not replace the place to get enough sleep. This medicine should be used only if the disease is diagnosed as obsessive-compulsive disorder, obstructive sleep apnea (also called apnea syndrome), or sleep problems caused by psoriasis.

This medicine may cause serious types of allergies, including hypersensitivity and vascular edema.

Stop using this medicine and check with your doctor immediately if you have any of the following symptoms: ulceration, peeling, skin softening, chills, cough, diarrhea, fever, or joint or muscle pain. Or red skin lesions. Or sore throat; sores, or white spots in the mouth or lips. Or unusual fatigue or weakness.

Do not drive the car, do not use machinery, avoid doing anything else that can be dangerous if you are not alert, so you know how to respond to this medication.

It may cause some people to get irritable, irritable, or have other abnormal behaviors. May also cause some people suicide thoughts or tend to become more depressed.

Before performing any medical tests, tell the doctor in charge that you are taking this medicine. The results of some tests may be affected by this medicine.

Do not take other medicines unless discussed with your doctor. This includes prescription or non-prescription medicines (OTCs), herbal supplements or vitamins.

Storage

Store the medicine in a sealed container at room temperature, away from heat, humidity and direct light.

 

Away from freezing.

Keep the medicine away from children.

Do not keep the expired medicine or medication that is no longer needed.

Ask your healthcare professional how to get rid of any medication you no longer use.


 

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