β-Estradiol powder

AASraw is with synthesis and production ability from gram to mass order of β-Estradiol powder (50-28-2) , under CGMP regulation and trackable quality control system.

β-Estradiol powder is the primary female sex hormone essential for the development and maintenance of tissues of the female reproductive system. It is the most potent form of mammalian estrogenic steroids.β-Estradiol mediates its biological activity in the body by the activation of the estrogen receptor. The activated estrogen receptor protein then translocates to the nucleus and regulates activity of different genes. In cell culture, β-Estradiol acts as a growth stimulant and has effects on cellular differentiation and on cells of the immune system.

Product Description

 

β-Estradiol powder video

 

 


 

I.β-Estradiol powder basic Characters:

 

Name: β-Estradiol powder
CAS: 50-28-2
Molecular Formula: C18H24O2
Molecular Weight: 272.38
Melt Point: 173°C to 180°C
Storage Temp: 15-30°C in air tight container
Color: White or of-white powder

 


 

II. β-Estradiol powder cycle

 

1. Names:

Chemical Names: β-Estradiol powder
Brand Names:

 

2. β-Estradiol powder Usage:

Estrogens direct the development of the female genotype in embryogenesis and at puberty. 17β-Estradiol powder is the major estrogen secreted by the premenopausal ovary. It is synthesized from testosterone primarily in the ovarian granulosa cells and placenta, but small amounts can be produced in the adrenal gland.1,2 Plasma 17β-Estradiol powder levels increase gradually between days 1-7 of the menstrual cycle followed by a sharp increase to a peak value of about 300 pg/ml on day 12, just prior to ovulation.

 

3.What is the dosage of β-Estradiol powder?

These studies demonstrate that daily estradiol doses of 0.2 mg and less are effective in reducing hot flashes. Effective doses of conjugated estrogens and estradiol administered by different routes achieve estradiol plasma concentrations of similar magnitude (between 35 and 100 pg/ml). Estrone plasma levels vary widely with these different regimens and do not seem to be directly related to efficacy. In summary, the literature indicates that efficacy of estrogen replacement for the treatment of the menopausal symptoms appears to relate to the magnitude of estradiol plasma levels; effective therapy is achieved by an estradiol regimen that maintains plasma estradiol levels of at least 35-55 pg/ml. Efficacy of estrogens in the prevention of osteoporosis as assessed by densitometry has been demonstrated for conjugated oral estrogens.

 

4.How β-Estradiol powder works?

After physiological or surgical menopause, women are suddenly deficient in their main estrogenic hormone, 17 beta-estradiol. Only a very small amount of estradiol is still produced from adrenal precursors. More than 50 per cent of all postmenopausal women suffer for varying periods of time from the symptoms of this estrogen deficiency, most notably vasomotor instability (hot flashes) and sleep disturbances. The trophic symptoms of estrogen deficiency have longer lasting and cumulative consequences: accelerated loss of bone density that eventually increases the risk of fractures, genitourinary atrophy resulting in dyspareunia and urinary atrophy; and lipoprotein changes with increased risk of coronary heart morbidity and mortality. Today estrogen deficiency is mainly treated by oral estrogens–either conjugated equine estrogens or estradiol–in milligram doses far in excess of what would be required by the parenteral route. Taken orally, estradiol is largely transformed to estrone through metabolism in the liver. Certain undesirable side effects of estrogen therapy (e.g., increased renin substrate) are caused by the unphysiologic nature of the oral route of administration. Dosage forms for parenteral estrogen administration have been widely studied: vaginal or percutaneous creams, intranasal solutions, and sublingual tablets. All of these result in a pronounced, transient elevation of plasma concentrations of estradiol and a minor increase of estrone. An improved regimen, which produces more constant plasma concentrations, is achieved with an experimental estradiol implant or with a vaginal ring delivering estradiol.

 

5.Warning:

Estradiol is a white or milky white ordorless crystalline powder. It is soluble in dioxane and acetone, slightly soluble in ethanol, and insoluble in water.
Estradiol is the intermediate between estradiol valerate and estradiol benzoate, and it is a type of estrogen drug. It can be used to treat uterine functional bleeding, primary amenorrhea, menopausal syndrome, and prostate cancer. Estradiol can promote and adjust the normal growth of female sex organs and secondary sex characteristics, promote mammary duct maturation and growth, and aid in posseting. Estradiol can also be used in biochemical research.

6.β-Estradiol powder:

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.

 

7.β-Estradiol powder Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

8.β-Estradiol powder Marketing:

To be provided in the coming future.

 

9.Does β-Estradiol powder Have Any Side Effects?

To develop a user-friendly, chemically inducible vector system for transient and stable plant transformation, we first attempted to optimize the existing β-Estradiol powder-responsive regulatory elements of the pER8 plasmid. To this end, the reading frame of the XVE fusion protein and the 3’UTR/terminator pea rbcS E9 region of the original pER8 vector were redesigned and in vitro synthesized. The original XVE reading frame contained 14 restriction sites which are generally used for cloning strategies to insert genes of interest into MCSs, while the optimized sequence now contains only two NdeI sites. Moreover, the codon usage of these sequences was optimized for expression in Arabidopsis. In addition, new restriction sites were included to allow simple replacement of the promoter, terminator, and the reading frame between promoter and terminator if required. Consequently, in the newly designed synthetic XVE sequence (designated as sXVE), 392 nucleotides were replaced, resulting in an overall 72% similarity between the original and synthetic reading frames.

In high dosages, estradiol can inhibit the release of anterior pituitary prolactin, thus decreasing breast milk secretion. However, nausea, vomiting and endometrial hyperplasia-induced bleeding may occur. Patients with liver or kidney failure should use with caution.

Do not use on breasts, vaginal area and vaginal mucosa.

 


 

III. β-Estradiol powder HNMR

 

We are Aprepitant powder supplie,Aprepitant powder for sale,Raw Aprepitant powder (170729-80-3) hplc≥98% | AASraw R&D Reagents

 


 

IV. How to buy β-Estradiol powder from AASraw?

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


 

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