β-Nicotinamide Mononucleotide

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Nicotinamide Mononucleotide(NMN) for anti-aging

Aging is a natural process that can take a toll on your physical, mental, and cosmetic health. The first signs of aging become apparent on the face and neck region in the form of fine lines and wrinkles. Cosmetic effects of aging are often further exaggerated by exogenous factors such as UV exposure resulting in photodamaged skin along with stress, anxiety, and environmental pollutants that clog the pores resulting in chronic irritation and acne.

These wrinkles are only the cosmetic and outwardly visible sign of aging but internally, they can affect your ability to perform daily life activities with the same enthusiasm and energy as before. Moreover, aging can affect your weight and metabolism, often causing an unhealthy weight gain associated with a slow basal metabolism rate.

Changes associated with aging cannot be avoided for the most part because some of them are the result of decreased mitochondrial metabolism and changes in gene expression. Most of the physiological changes that occur with aging are the result of decreased NAD+ levels, an important coenzyme for homeostasis and metabolism that is found in all living organisms.

During our youth, this coenzyme partakes in almost all of the mitochondrial energy-producing reactions and is abundantly found in the body. However, as we age, NAD+ levels begin to decrease significantly.

Anti-aging supplements are widely promoted and used by people all over the world in hopes of counteracting the effects of aging. However, not all of them are effective as most of them do not affect the NAD+ levels in the body. As a result of several studies. scientists and researchers have found a solution to fight the signs of aging, an elixir of life, namely, Nicotinamide Mononucleotide that immediately after oral consumption converts to NAD+ in the body.

There are three “Key Point” before you read more information about NMN powder:

①NAD+ is an essential coenzyme required for life and cellular functions.

②Levels of NAD+, especially its NAD+ form, naturally decrease with age in many tissues.

③The body creates NMN as an intermediate step or “precursor” to NAD+. Put simply: higher NMN levels mean higher NAD+ levels.

What is Nicotinamide Mononucleotide(NMN) Powder?

Nicotinamide Mononucleotide is a nucleotide that is derived from niacin or vitamin B3 that can also be found, as is, in certain fruits and vegetables such as avocados and edamame. NMN has recently gained traction as a potential anti-aging supplement, mostly as the result of the publication of the book, Lifespan, by David Sinclair.

NAD+ has been known to be the hallmark of aging for quite a while but fighting the effect of aging on its levels has been difficult. This is mostly because initial studies focused on increasing NAD+ levels in the body using NAD+ supplements. However, it was soon discovered that NAD+ has poor bioavailability in the body meaning that it is not as readily absorbed, and consuming it exogenously has no effect on its endogenous levels.

NMN powder is a potent precursor of NAD+ which is crucial in the energy production process in the human body. However, the first research into the use of NMN powder or supplement as a potential anti-aging supplement was only conducted in the year 2020. NMN still has a long way to go in the world of research but the studies performed so far have proven the hypothesized benefits and effects of NMN on aging.

NAD+ levels can be increased by one of its two important precursors, NMN as mentioned above or NR. NMN and NR go together, with the conversion of NMN into NR being crucial for the former’s absorption in the body. NR stands for Nicotinamide riboside which can increase the endogenous NAD+ levels significantly. Supplementation with NR to fight the effects of aging have been thoroughly studied with NR supplements being declared as ‘safe and tolerable’ supplements.

How does NMN work on body?

NMN plays a vital role in the energy production process and DNA repair in the body, albeit indirectly. NMN promotes the synthesis or production of NAD+ in the body to overcome its deficiency, through the salvage pathway. NAD+ can be synthesized in more than one way and the salvage pathway depends on the proper functioning of NMN. Salvage pathway refers to a pathway that produces NAD+ with the end-products of NAD+ breakdown such as niacinamide or NAM. NAM directly converts to NMN which then, through various steps, produces NAD+. This is the most important function of NMN in the body and is the main reason behind NMN supplements’ rising popularity.

Once you take NMN supplements orally, it is believed that they are converted to NR in the body because the NMN compound is unable to pass through the membranes, into the cells. After NR enters the cell, it is then converted back to NMN via the effects of a specific enzyme; nicotinamide ribose kinase or NRK. This NMN then undergoes the salvage pathway for biosynthesis of NAD+ to replenish the latter’s levels in the human body.

It is important to note here that NAD+ replenishment through NMN supplementation does not just result in increased energy but also has several other health benefits which only add to the appeal of NMN supplementation.

Can we expect any health benefits from NMN?

NMN’s anti-aging properties are not just the result of increased NAD+ levels but also the result of NMN’s pathways and functions in the human body. The main benefit of NMN still is its ability to increase cellular and physical energy as it is an NAD+ booster however, other benefits should not be overlooked especially if you are looking into whether NMN supplementation is the right choice for you.

Being an NAD+ booster allows NMN to produce several other health benefits, such as:

❶ Management of Obesity

The incidence of obesity has increased significantly since 30 years ago, with the childhood obesity percentage almost doubling over these 30 years. This is especially worrisome because obesity predisposes you to several other comorbidities that can be fatal. A low basal metabolic rate is the main reason behind age-related obesity often seen in aging individuals. Controlling this specific type of obesity requires a multifactorial approach that targets hunger hormones along with metabolic rates. A study performed in Qatar found that NMN supplementation in animal models resulted in increase gene expression of two key hormones in appetite suppression and metabolism check; leptin and sirtuin, respectively. This study shows that oral ingestion of NMN could suppress hunger to help you lose weight while also increasing the metabolism rate, both of which exaggerate the weight loss you may experience.

Furthermore, researchers found that NMN increases NAD+ levels which in fat cells has a metabolism-enhancing effect, further aiding weight loss.

❷ Diabetes Control

Diabetes is one of the complications of obesity and using NMN supplements to manage and treat obesity can prevent diabetes from developing. But that is not the only effect of NMN on blood sugar levels. Decreased NAD+ levels were found to be related to decreased functioning of beta cells in the pancreas, the main source of insulin in the body. Researchers believe this to be the main pathophysiology behind the development of diabetes mellitus type 2 in older individuals.

A study performed on animal models showed that diabetic and aged mice, when given NMN supplements, had improved beta-cell function as it replenishes the NAD+ stores in the body. Another study focused on finding a treatment target for age-associated and obesity-related diabetes mellitus type 2 found that NMN supplements had the potential to affect the liver and increase fat oxidation. They could also decrease fat storage in the body while also enhancing glucose tolerance in the body.

NMN supplements have several pathways through which they help improve glucose tolerance and insulin resistance, thus helping manage diabetes mellitus type 2 in aging individuals. Similar pathways are used to effectively alleviate the symptoms of other metabolic disorders that develop during the aging process.

❸ Increased Function of Immune System

Given that supplementation with NMN only recently became a viable option that has been researched, at least on animal models, it is no wonder that NMN’s role was studied with regards to COVID-19 infection.

While studying the different roles of the multitasking coenzyme, NAD+, researchers found that it also plays a vital role in the proper functioning of the immune system. The recent COVID-19 pandemic pushed the researchers to study the specific connection between NMN supplements, increased NAD+, and enhanced immune function to counteract the effects of the virus.

One such study found that depleted NAD+ levels and subsequently, increased age, resulting in severe forms of the infection. It was also found that these patients were at higher risk of comorbidity and mortality as a result of COVID-19 infection. As a result of these findings, it can be hypothesized that NMN supplementation may be able to decrease the severity with which COVID-19 affects the immune system and the human body.

❹ Improved Female Fertility

Women are affected by the biological clock that limits their reproductive abilities with age. Different studies performed on female animal models have found that NMN supplementation may be able to reduce these limits and even treat age-associated infertility in some cases.

A study performed on naturally aged, female mice found that depletion of NAD+ levels can result in decreased oocyte quality along with a significant decrease in oocyte numbers, which consequentially reduces reproduction ability and fertility. Restoring the NAD+ levels in these animal models with NMN supplementation was found to increase the quality of the oocyte and its numbers, hence improving reproduction ability.

Another study was performed to assess exactly what reduces the quality of oocytes with age. For this study, oocytes from older females were collected and studied, in-depth to understand the pathophysiology. Researchers found that decreased oocyte quality was the result of point mutations in the mitochondrial DNA of the oocyte, which develops due to an imbalance of NAD+ levels. This is why NMN supplementation to increase NAD+ levels is believed to improve fertility and reproductive health, especially in aged women.

Since aged women lose most of their reproductive abilities during menopause, NMN supplements, along with being able to improve reproductive health may also be able to reverse menopause, to an extent. This would allow women to be fertile longer and have a higher quality of oocytes even after they cross the general age threshold.

❺ Increased Blood Flow

According to research performed by Dr. DAvid Sinclair, the biologist responsible for the fame of NMN supplements, as we age, the endothelial cells lining our blood vessels decrease in number and quality. This then affects the nutrients that are passing from the blood to the tissues through which the vessels pass, hence affecting the overall quality of the blood vessel. These changes are believed to be the main factor behind the increased incidence of blood vessel pathologies among aged individuals.

NMN supplementation or NR supplementation results in increased NAD+ levels, which according to this study causes endothelial cells to become active and potent to produce new blood vessels when old ones stop functioning properly.

❻ Enhanced Cognitive Function

Neurodegenerative disorders are common disorders that affect the brain, decreasing cognitive function and quality of life. Supplementation with NMN to increase NAD+ levels is believed to be highly effective in improving cognitive function and enhancing the survivability of brain cells.

In a study where animal models with traumatic brain injury and neurodegeneration were given a specific compound,  P7C3-A20, it was found that this compound improved cognitive function and stopped the neurodegenerative processes.

P7C3-A20 is an NMN-producing compound that then produces NAD+. Giving mice with TBI this compound was found to not only have cognitive benefits but also was found to increase the functional and structural integrity of the blood-brain barrier, as this compound is a part of the membrane.

❼ Improved Muscle Function and Increased Endurance

Athletes that would like to improve their endurance abilities should take NMN supplements as it was recently found that these supplements have the potential to improve their aerobic capacity. This benefit of NMN supplements is mostly due to the energy production effect of NAD+ in the muscle, but it is important to note that these athletes also experience a significant increase in their muscles’ oxygen uptake levels.

What is the NMN potential risks?

NMN is a naturally found compound in the human body, that after extensive research and analysis were found to have no risks or complications associated with it. NMN, when manufactured properly by the NMN supplier and stored properly in the NMN powder factory and your home, is completely safe for human consumption. The storage of NMN powder is important because if it is stored in a hot place, it will turn into niacinamide and begin to slowly poison your body when you consume it.

You do not have to worry as pure NMN powder by the NMN company is always stored appropriately, in a cold and dry place. Moreover, NMN powder manufacturers also print the exact directions of use and storage on the packaging of the supplements so that you know how best to use them, without resulting in severe complications.

It is also worth noting that regular use of the NMN supplements can result in a decreased ability of the supplements to produce the desired effects. For this reason, it is recommended that you take a break from the supplements when you begin to notice decreased NMN benefits such as reduced quality of sleep and increased incidence of infections.

As far as proper care is taken during the manufacturing process and storage, both at home and at the factory, there are no risks and side effects associated with NMN use.

Where to buy the best NMN Powder?

You can buy NMN powder and other forms of NMN supplements from online pharmacies, health stores, and their local counterparts. You can also buy NMN powder bulk bags which contain huge amounts of NMN powder, although it is industrial grade and most commonly bought by big companies trying to manufacture NMN pills and capsules.

You can also buy NMN powder from Amazon or Amazon Prime, but you should be careful to buy the real product from verified vendors as many random sellers may trick you into paying a huge amount for a dupe or a fake, that either has no effect on your health or has a negative effect on your health.

Before you start shopping for an NMN powder, you should check a few things to ensure you are buying the best product for you.

The best NMN supplement is that which is manufactured with all safety guidelines and protocols in place. NMN suppliers should ensure that the utmost regard is given to preventing contamination of the NMN powder with any toxins or contaminants that can cause more harm than good to the human body.

Moreover, the NMN powder should be, as mentioned above, should be stored in appropriate conditions that should also be maintained during the transportation of the supplements.

Ask frequently questions(FAQ) about NMN Powder

Can NMN powder reverse aging?

NMN powder is advertised to be an anti-aging supplement and rightfully so, as it increases the levels of NAD+ which plays a crucial role in decreasing your energy levels as you age. Not only that, NMN powder can reverse the effects of aging on different organ systems of your body, and take you back to your youthful, energetic days.

Should I take NMN Powder?

NMN Powder has several benefits that have been studied in detail, in animal models and in the laboratory. Some of these benefits have been studied in humans, and have produced positive results. If you are starting to see the signs of aging whether it is in the form of decreased endurance, athletic abilities, or cosmetic signs, you may benefit from taking NMN supplements. Their use is especially recommended for those trying to reverse the symptoms of aging.

Is NMN powder Safe?

NMN powder has been thoroughly researched to assess the different functions and benefits its use may have on the human body. During these studies, the potential side effects were also analyzed only for the results to show that the use of NMN has no side effects associated with it. Any complication that can occur with NMN powder use is a result of a human or clerical error made during transport or storage. None of it has anything to do with the actual ingredient of the anti-aging supplement.

How much does NMN powder cost?

NMN powder is a readily available and relatively expensive supplement but it is considered to be worth it, given its huge list of scientifically proven benefits. The high price of NMN powder is not due to the long list of benefits but rather a result of the highly extensive manufacturing process that itself is quite costly for most NMN manufacturers. Given the expensive nature of the supplement, you should always ensure that you are buying the real product from certified vendors, especially if you are buying NMN online.

Summary

NMN supplements are becoming more popular by the day, thanks to the work of the biologist David Sinclair who has also spent a significant portion of his is academic career researching and studying the effects of this vitamin B3-derived nucleotide.

NMN is a precursor of NAD+ which is a coenzyme necessary for the proper functioning of several metabolic, immune, and hormonal pathways. The main function of the NAD+ is the role it plays in the process of energy production. Since NAD+ is crucial for energy production, the physiological decrease in its levels as one age causes a marked reduction in energy levels. NMN supplementation can help increase energy by boosting NAD+ levels in the body.

NMN also has several other benefits such as improving metabolic function, enhancing cardiac, cognitive, circulatory, and immune system functions. These functions are backed by scientific evidence and data, which calls for widespread use of NMN supplementation in aged individuals to help them time travel back to their youthful days.

Apart from the several benefits of NMN, its popularity can also be credited to the fact that it does not have any significant risks or complications associated with its use. If you are feeling your age catch up with you and would like a drink from the fountain of youth, NMN supplements may be the best choice for you.

Raw β-Nicotinamide Mononucleotide(NMN) Powder Testing Report-HNMR

What is HNMR and What does HNMR spectrum tell you? H Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.

β-Nicotinamide Mononucleotide Powder(1094-61-7)-COA

β-Nicotinamide Mononucleotide Powder(1094-61-7)-COA

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Reference

[1] Tarragó MG, Chini CC, Kanamori KS, Warner GM, Caride A, de Oliveira GC, et al. (May 2018). “+ Decline”. Cell Metabolism. 27 (5): 1081–1095.e10. doi:10.1016/j.cmet.2018.03.016. PMC 5935140. PMID 29719225.

[2] Stipp D (March 11, 2015). “Beyond Resveratrol: The Anti-Aging NAD Fad”. Scientific American Blog Network.

[3] Cambronne XA, Kraus WL (October 2020). “+ Synthesis and Functions in Mammalian Cells”. Trends in Biochemical Sciences. 45 (10): 858–873. doi:10.1016/j.tibs.2020.05.010. PMC 7502477. PMID 32595066.

[4] Bogan KL, Brenner C (2008). “Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition”. Annual Review of Nutrition. 28: 115–30. doi:10.1146/annurev.nutr.28.061807.155443. PMID 18429699.

[5] Yue Yang, Anthony A. Sauve. NAD+ metabolism: Bioenergetics, signaling and manipulation for therapy. Biochim Biophys Acta, 2016; DOI: 10.1016/j.bbapap.2016.06.014.

[6] Mills KF, Yoshida S, Stein LR, Grozio A, Kubota S, Sasaki Y, Redpath P, Migaud ME, Apte RS, Uchida K, Yoshino J, Imai SI. Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell Metab, 2016; DOI: 10.1016/j.cmet.2016.09.013.

[7] Niels J. Connell, Riekelt H. Houtkooper, Patrick Schrauwen. NAD+ metabolism as a target for metabolic health: have we found the silver bullet? Diabetologia, 2019; DOI: 10.1007/s00125-019-4831-3.

[8] Ann Katrin-Hopp, Patrick Grüter, Michael O. Hottiger. Regulation of Glucose Metabolism by NAD+ and ADP-Ribosylation. Cells, 2019; DOI: 10.3390/cells8080890.

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