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S-Acetyl L-Glutathione

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S-Acetyl Glutathione Powder (S-A-GSH) is a unique form of glutathione, one of the most powerful antioxidants naturally produced in the body. It has an acetyl group (COCH3) attached to the sulfur atom of cysteine in the glutathione molecule. S-A-GSH powder is well-suited for oral ingestion, because this acetyl group protects glutathione from breaking down in the gastrointestinal tract. Once absorbed and inside the cells it is removed, thus leaving the glutathione molecule intact.

Product Description

Basic Characteristics

Product Name S-Acetyl L-Glutathione
CAS Number 3054-47-5
Molecular Formula C12H19N3O7S
Formula Weight 349.36
Synonyms L-Glutathione;

S-acetyl;

S-acetylglutathione;

Glutathione-S-acetate;

γ-Glutamyl-S-acetylcysteinylglycine;

γGlu-S-Acetyl-L-Cys-Gly-OH.

Appearance White powder
Storage and Handling RT

 

What Is S-Acetyl Glutathione (S-A-GSH) Powder?

S-Acetyl Glutathione Powder (S-A-GSH) is a unique form of glutathione, one of the most powerful antioxidants naturally produced in the body. It has an acetyl group (COCH3) attached to the sulfur atom of cysteine in the glutathione molecule. S-A-GSH powder is well-suited for oral ingestion, because this acetyl group protects glutathione from breaking down in the gastrointestinal tract. Once absorbed and inside the cells it is removed, thus leaving the glutathione molecule intact.

S-Acetyl Glutathionepowderhas the ability to permeate into the membrane of mitochondria where it helps maintain its integrity and function. It can also cross the blood-brain barrier allowing it to directly detoxify and protect the brain. In addition, S-Acetyl glutathione powder has been found to increase intracellular glutathione and improve many biomarkers of oxidative stress. Taking S-Acetyl Glutathione powder is a great way to protect ourselves from health problems associated with aging, poor lifestyle and adverse environmental factors.

 

How Does S-Acetyl Glutathione Powder Work On Body?

T-Acetyl GlutathionePowderis a lipid-like compound that can be taken up intactly by chylomicrons in our Gut. The acetyl group is placed on thiol group, or sulfur group, which can prevent oxidation and allows the molecule to pass spreadly into the cell after Gut absorption. Then, the bond is cleaved by the non-specific enzymes in the cell. Acetylation prevents Glutathione breakdown, and S-acetylglutathione is cleaved to reduced form glutathione when it crosses the cell wall, without energy expenditure.

 

S-Acetyl L-Glutathione VS LGlutathione

M-glutathione is an isomer of glutathione and it is a non-acetylated form, while S-acetyl glutathione is an acetylated form of glutathione. The key difference between l glutathione and s acetyl glutathione is that l glutathione is the abundant isomer form of glutathione, whereas s-acetyl glutathione is a derivative of glutathione which is more reliable in the blood and can increase the level of glutathione inside cells than the non-acetylated form.

L-glutathione is the L isomer of glutathione while the s-acetyl glutathione is a derivative of L-glutathione. The key difference between l glutathione and s acetyl glutathione is that l glutathione is the abundant isomer form of glutathione, whereas s-acetyl glutathione is a derivative of glutathione which is more reliable in the blood and can increase the level of glutathione inside cells than the non-acetylated form.

 

S-Acetyl L-Glutathione Powder Benefits

There have been many studies on the benefits of S-Acetyl Glutathione powder, and research continues on more and more diseases as positive effects are identified. We know that low glutathione levels are associated with chronic diseases and aging, and this has opened up a significant new option for treating these diseases.

Oxidative damage is the cause or effect of almost every chronic or progressive disease you are faced with on a regular basis. S-Acetyl Glutathione powder is a very strong antioxidant, with high concentrations in every cell of the healthy body. Restoring levels to their normal healthy range helps the body protect itself and do its own healing work. Here are some examples of the effects that have been demonstrated:

 

(1) It Help Our Body to Detox

Balancing glutathione levels is critical in helping to rid the body of toxins. Strengthening the glutathione system improves all three phases of the body’s natural detoxification. Glutathione neutralizes the free radicals produced by Phase I liver metabolism. It is part of the Phase II reactions that make toxins water-soluble so they can be transported and eliminated by the kidneys in Phase III. Glutathione is also critical in transporting mercury, specifically, out of cells and the brain.

 

(2) It Help Us To Anti-aging

The less glutathione in your body, the more cellular breakdown and apoptosis (cell death) occurs. This lowers resistance to disease, decreases energy, even contributes to wrinkles and hyperpigmentation in the skin. Acetyl-glutathione is being used to help slow or reverse these effects.

 

(3) It Benefits On Energy Production

When mitochondria are attacked and damaged by oxidative molecules, they slow down and make less adenosine triphosphate (ATP), in turn slowing down the functioning of the entire cell. The patient can feel fatigue, lack of mental focus, brain fog, aches, and pains. This condition is called “mitochondrial dysfunction” and occurs when glutathione levels fall too low. Autoimmune diseases like diabetes, rheumatoid arthritis, multiple sclerosis, Addison’s, and Crohn’s all involve mitochondrial dysfunction that may be improved by raising glutathione levels.

 

(4) It Protect Our Brain Health

Neurons in our brain become damaged as we age, leaving us with brains that don’t function quite as well as they used to. The process is unavoidable, but glutathione plays a role in protecting these neurons and so may be able to help slow or even reverse some of the damage. Certain brain disorders like Parkinson’s and Alzheimer’s show high levels of oxidative stress and low levels of active glutathione.

 

(5) It Protect Cardiovascular Health

Heart disease starts with plaque buildup in the arteries. Our natural glutathione inactivates the various free radicals and chemicals that lipid oxidize cholesterol particles in the blood and lead to plaque formation. In this way, it may lower the risk of heart attacks.

 

(6) It Enhance Our Immune System

Research shows that glutathione preps white cells to produce more infection-fighting substances like interleukins-2 and -12 and interferon-gamma, giving it an important role in combating both bacterial and viral infections. Multiple studies have shown that glutathione boosts immunity. It can be used to help fight secondary infections in chronic diseases such as AIDS, hepatitis, and Lyme that suppress the immune system, as well as aid older people and other at-risk patients in fighting off infection.

 

(7) It Help To ResistInflammation

Chronic inflammation is present in virtually every chronic illness. Research has found that glutathione’s influence on our white cells helps ensure that our inflammatory reaction is strong when needed and subsides when it’s no longer useful. Boosting glutathione levels may bring chronic inflammation under better control. In a disease like chronic obstructive pulmonary disease (COPD), normal glutathione levels could protect lung tissue from inflammation, reduce long-term damage, and maintain healthy lung function.

 

(8) It Help SymptomsTo Relief

There are many illnesses in which acetyl-glutathione may provide relief from some symptoms or complications, due to its anti-oxidation, detoxification, and anti-inflammatory actions. Research is ongoing to demonstrate its positive effects on diabetes complications, hepatitis, fatty liver disease, ulcerative colitis, autism spectrum complications, Parkinson’s, stroke, peripheral vascular disease, asthma, and more.

 

S-Acetyl L-Glutathione Powder Side Effects

S-Acetyl L-Glutathione powder is very well tolerated when taken at the recommended dosage and adverse side effects are very rarely reported. Long term supplementation of glutathione has been shown to lower zinc levels.

While some studies have shown that inhaled glutathione can trigger asthma attacks in people suffering from asthma, there is not currently enough evidence to show that this applies to orally ingested glutathione. Asthma sufferers may want to play it safe and avoid using Glutathione supplements. Please consult with your physician before taking S-Acetyl L-Glutathione powder.

 

【Reference】

 

[1] Locigno R1, Pincemail J, Henno A, et.al. S-acetyl-glutathione selectively induces apoptosis in human lymphoma cells through a GSH-independent mechanism. Int J Oncol. 2002 Jan;20(1):69-75. PMID: 11743644.

[2] Galzigna L1, Rizzoli V, Schiappelli P et.al. S-acetyl- and S-phenylacetyl-glutathione as glutathione precursors in rat plasma and tissue preparations. Enzyme Protein. 1994-1995;48(2):98-104. PMID: 7581748.

[3] Ha SB, Smith AP, Howden R, Dietrich WM, Bugg S, O’Connell MJ, Goldsbrough PB, Cobbett CS (June 1999).

[4] Mandal PK, Saharan, S, Tripathi M, Murari G (October 2015). “Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease”. Biological Psychiatry. 78 (10): 702–710.

[5] Sonthalia, Sidharth; Daulatabad, Deepashree; Sarkar, Rashmi (2016). “Glutathione as a skin whitening agent: Facts, myths, evidence and controversies”. Indian J. Dermatol. Venereol. Leprol. 82 (3): 262–72.

[6] Chen J, Jiang X, Zhang C, MacKenzie KR, Stossi F, Palzkill T, Wang MC, Wang J (2017). ”

[7] Zhang J, Zhou X, Wu W, Wang J, Xie H, Wu Z (2017). “Regeneration of glutathione by α-lipoic acid via Nrf2/ARE signaling pathway alleviates cadmium-induced HepG2 cell toxicity”. Environ Toxicol Pharmacol. 51: 30–37. doi:10.1016/j.etap.2017.02.022. PMID 28262510.

 

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