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CAS 334-50-9

Spermidine trihydrochloride

Rating: Category: Spermidine Powder

Spermidine trihydrochloride powder is a natural polyamine produced from putrescine and decarboxylated S-adenosylmethionine (dcSAM) by spermidine synthase, is a novel autophagy inducer and negatively modulates N-methyl-d-aspartate (NMDA). Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements. Spermidine hydrochloride is found widely in nature and essential for tissue growth; Used as a tool in biochemical research; “Spermidine hydrochloride is a polyamine compound, C7H22Cl3N3, found in ribosomes and living tissues and having various metabolic functions within organisms.

Description

Product Description

Product Name	Spermidine trihydrochloride
CAS Number	334-50-9
Molecular Formula	C7H22Cl3N3
Formula Weight	254.6
Synonyms	N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride;1,8-Diamino-4-azaoctane trihydrochloride;1,5,10-Triazadecane trihydrochloride;S permidine.3HCl
Appearance	White powder
Storage and Handling	Dry, dark and 0 – 4 C for short term, or -20 C for long term.

Reference

[1] Kishi et al (1998) Spermidine, a polyamine site agonist, attenuates working memory deficits caused by blockade of hippocampal muscarinic receptors and mGluRs in rats. Brain Res. 793 311 PMID: 9630697.

[2] Munir et al (1993) Polyamines modulate the neurotoxic effects of NMDA in vivo. Brain Res. 616 163 PMID: 8358608.

[3] Williams et al (1989) Effects of polyamines on the binding of [3H]-MK801 to the N-MthD.-aspartate receptor: pharmacological evidence for the existence of a polyamine recognition site. Mol.Pharmacol. 36 375 PMID: 2554112.

[4] Galluzzi et al (2017) Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles. Nat.Rev.Drug.Discov. PMID: 28529316.

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