|Product Name||Sesamin Powder|
|Purity||50%-98% by HPLC|
Sesamum indicum L;
black sesame seed extract.
|Appearance||Light yellow or white fine powder|
|Storage and Handling||Stored in cool & dry places, protected from direct sunlight and heat.|
Sesamin Powder Description
Sesamin powder is a naturally occurring lignan that is present in sesame seed and pure sesame oil. It belongs to a group of fibrous plant compounds known as lignans, along with a closely related lignan called sesamolin powder. Numerous studies on rats and mice have suggested various health benefits of sesamin powder. This compound is known to promote anti-inflammatory effects, normalize blood pressure, lower cholesterol, aid in vitamin E absorption, protect the liver, and contribute to weight loss. Sesamin powder is additionally believed to have antioxidant effects
Sesamin Powder Mechanism Of Action
Sesamin powder inhibits the conversion of DGLA to arachidonic acid, and consequently decreases the formation of proinflammatory 2-series prostaglandins. Sesamin powder can decrease cholesterol levels, while increasing high density lipoprotein (HDL aka “good cholesterol”) levels, sesamin powder can be an anti-inflammatory skin problem: sesamin powder can inhi bit the growth of SC (skin cancer) cell. It can protect skin from UV rays.
Sesamin Powder Function/Benefits
♦ Sesamin powder has effect on improving the lipid profile.
♦ Sesamin powder has function of normalizing the blood pressure.
♦ Sesamin powder can be used for loss weight.
♦ Sesamin powder can increase ketone production.
♦ Sesamin powder also has function of anti-inflammatory.Sesamin has effect on antiviral, fungicides, antioxidants, insecticide synergist.
♦ Sesamin powder can also be used to the treatment of bronchitis.
♦ Sesamin powder has the function of inhibition the influenza virus, Sendai virus and Mycobacterium tuberculosis.
Sesamin Powder Application
※ Seamin powder applied in food industry.sesamin is mainly used as food additives;
※ Seamin powder applied in health product, sesamin is mainly used as capsules or pills;
※ Seamin powder applied in pharmaceutical field, sesamin is used as medicine raw materials as capsules etc;
※ Seamin powder applied in cosmetics field.
Sesamin powder is the most prominent lignan compound found in sesame seeds, one of the two highest sources of lignans in the human diet (the other being flax). Sesamin powder is catered to be a nutritional supplement that confers antioxidant and antiinflammatory effects (if touting its health properties) or possibly being an estrogen receptor modulator and fat burner (if targeting atheltes or persons wishing to lose weight).
Sesamin powder has a few mechanisms, and when looking at it holistically it can be summed up as a fatty acid metabolism modifier. It appears to inhibit an enzyme known as delta-5-desaturase (Δ5-desaturase) which is a rate-limiting enzyme in fatty acid metabolism; inhibiting this enzyme results in lower levels of both eicosapentaenoic acid (EPA, one of the two fish oil fatty acids) as well as arachidonic acid, and this mechanism appears to be relevant following oral ingestion. The other main mechanism is inhibiting a process known as Tocopherol-ω-hydroxylation, which is the rate limiting step in the metabolism of Vitamin E; by inhibiting this enzyme, sesamin causes a relative increase of vitamin E in the body but particularly those of the gamma subset (γ-tocopherol and γ-tocotrienol) and this mechanism has also been confirmed to be active following oral ingestion.
There are some other mechanisms in place which seem promising (protection against Parkinson’s Disease as well as promotion of bone mass) but most of the mechanisms including estrogen receptor modulation, fat burning from the liver, and activation of the antioxidant response element (ARE) have not been confirmed in humans and have their reasons to suspect that they do not occur; this includes either a concentration that is too high to matter for oral supplementation, or in the case of fat burning it being a process that seems to be exclusive to rats.
In the end, Sesamin powder serves a pretty interesting role as having the potential to augment γ-tocopherol and γ-tocotrienol metabolism by preventing their degradation; increasing the levels of these vitamin E vitamers has a lot of therapeutic benefits in and of itself, and since they are quite expensive to purchase as supplements then Sesamin powder could be a cheap workaround or something used to ‘cut’ the vitamin E.
Reference Ikan, Raphael (1991). Natural Products: A Laboratory Guide 2nd Ed. San Diego: Academic Press, Inc. p. 50. ISBN 978-0123705518.  Lim JS, Adachi Y, Takahashi Y, Ide T (Jan 2007). “Comparative analysis of sesame lignans (sesamin and sesamolin) in affecting hepatic fatty acid metabolism in rats”. Br J Nutr. 97 (1): 85–95. doi:10.1017/S0007114507252699. PMID 17217563.  H. Lei, J. Han, Q. Wang, S. Guo, H. Sun, X. Zhang.Effects of sesamin on streptozotocin (STZ)-induced NIT-1 pancreatic β-cell damage Int. J. Mol. Sci., 13 (12) (2012), pp. 16961-16970.  Z. Li, L. Li, H.R. Zielke, L. Cheng, R. Xiao, M.T. Crow, W.G. Stetler-Stevenson, J. Froehlich, E.G. Lakatta Increased expression of 72-kd type IV collagenase (MMP-2) in human aortic atherosclerotic lesions Am. J. Pathol., 148 (1) (1996), pp. 121-128.  N. Liu, C. Wu, L. Sun, J. Zheng, P. Guo Sesamin enhances cholesterol efflux in RAW264.7 macrophages Molecules, 19 (6) (2014), pp. 7516-7527.  P. Xu, F. Cai, X. Liu, L. Guo Sesamin inhibits lipopolysaccharide-induced proliferation and invasion through the p38-MAPK and NF-κB signaling pathways in prostate cancer cells Oncol. Rep., 33 (6) (2015), pp. 3117-3123.  Y. Zhao, Q. Wang, M. Jia, S. Fu, J. Pan, C. Chu, X. Liu, X. Liu, Z. Liu (+)-Sesamin attenuates chronic unpredictable mild stress-induced depressive-like behaviors and memory deficits via suppression of neuroinflammation J. Nutr. Biochem., 64 (2019), pp. 61-71.