Apatinib basic Characters
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Apatinib (811803-05-1)usage in steroids cycle
Apatinib (CAS 811803-05-1), also known as YN968D1, Mesylate.
Cancer patients were administered varied doses of Apatinib daily for 28 days. Apatinib was well tolerated at doses below 750 mg/day, 3 of 3 dose limiting toxicities were reported at 1000 mg/day and the maximum tolerated dose is determined to be850 mg/day.
Warning on Apatinib
You must know the side effects when you take Apatinib. The common side effectsof apatinib were hypertension and hand-foot syndrome; however, the toxicity of apatinib was controllable and tolerable.
Rivoceranib (Apatinib, YN968D1) is an orally bioavailable experimental drug candidate being developed outside of China by LSK BioPharma, for the treatment of solid tumors including advanced or metastatic gastric cancer, colorectal cancer, and hepatocellular carcinoma. YN968D1 was first synthesized and patented by Advenchen Laboratories in Southern California. Apatinib is currently marketed in China for advanced gastric cancer by the Chinese-territory license-holder, Jiangsu Hengrui MedicineCo., Ltd under the brand name Aitan®. LSK BioPharma holds the global rights (excluding China) and has partnered for the development and marketing of rivoceranibin South Korea.
Rivoceranib is a selective potent inhibitor of vascular endothelial growth factor receptor-2 (known as VEGFR2) which mediates the primary pathway for tumor-mediatedangiogenesis. It has been clinically tested in over 1,000 patients worldwide and hasdemonstrated efficacy in numerous cancers including gastric cancer, colorectal cancer, hepatocellular carcinoma, non-small cell lung cancer, esophageal cancer, thyroidcancer, mesothelioma, and neuroendocrine tumors. It has also shown potential tosignificantly improve outcomes in combination with chemotherapeutics and immunotherapy, as well as for maintenance therapy.
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