Crizotinib powder (877399-52-5) | anaplastic lymphoma kinase inhibitor
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Crizotinib powder (877399-52-5)

Rating: SKU: 877399-52-5. Category:

AASraw is with synthesis and production ability from gram to mass order of Crizotinib powder (877399-52-5), under CGMP regulation and trackable quality control system.

Product Description


Crizotinib powder video




Crizotinib powder basic Characters


Name: Crizotinib powder
CAS: 877399-52-5
Molecular Formula: C21H22Cl2FN5O
Molecular Weight: 450.343
Melt Point: 197-203°C
Storage Temp: RT
Color: white to pale-yellow powder



Crizotinib powder in cancer treatment usage



Crizotinib powder, Xalkori powder


Crizotinib powder Usage

Crizotinib powder is a cancer medication that interferes with the growth and spread of cancer cells in the body. Crizotinib powder is used to treat non-small cell lung cancer.

Crizotinib powder is a tyrosine kinase inhibitor. It works by blocking an enzyme called anaplastic lymphoma kinase (ALK). Crizotinib powder only works in cancer cells that have an overactive version of ALK. About 5 in 100 people (5%) with NSCLC have this. It is called ALK positive disease.

Your doctor might recommend you have Crizotinib powder if you have advanced non small cell lung cancer that is ALK positive.

XALKORI powder capsules are supplied as printed hard-shell capsules containing 250 mg or 200 mg of Crizotinib powder together with colloidal silicon dioxide, microcrystalline cellulose, anhydrous dibasic calcium phosphate, sodium starch glycolate, magnesium stearate, and hard gelatin capsule shells as inactive ingredients.

The pink opaque capsule shell components contain gelatin, titanium dioxide, and red iron oxide. The white opaque capsule shell components contain gelatin and titanium dioxide. The printing ink contains shellac, propylene glycol, strong ammonia solution, potassium hydroxide, and black iron oxide.

Crizotinib powder is a capsule. You swallow it whole with a glass of water. You can have it with or without food.

You must take capsules according to the instructions your doctor or pharmacist gives you.
You should take the right dose, not more or less.

Never stop taking a cancer drug without talking to your specialist first.

You take it twice a day – once in the morning and once in the evening.

You usually carry on taking it for as long as it is still working, unless the side effects get too bad.

You have blood tests before starting treatment and during your treatment. They check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working.


Warning on Adrafinil

Cancer drugs can interact with some other medicines and herbal products. Tell your doctor or pharmacist about any medicines you are taking. This includes vitamins, herbal supplements and over the counter remedies.

Avoid grapefruit and grapefruit juice because they can increase the side effects.

Pregnancy and contraception
This drug may harm a baby developing in the womb. It is important not to become pregnant or father a child while you are having treatment with this drug and for at least 3 months afterwards. Talk to your doctor or nurse about effective contraception before starting treatment.

We don’t know how this treatment might affect fertility. You may not be able to become pregnant or father a child after treatment with this drug. Talk to your doctor before starting treatment if you think you may want to have a baby in the future.

Some men might be able to store sperm before starting treatment. Some women might be able to store eggs or embryos before treatment.

Don’t breastfeed during this treatment because the drug may come through in your breast milk.

Treatment for other conditions
Always tell other doctors, nurses, pharmacists or dentists that you’re having this treatment if you need treatment for anything else, including teeth problems.

Don’t have immunisations with live vaccines while you’re having treatment and for at least 6 months afterwards.

You can:

-have other vaccines, but they might not give you as much protection as usual
-have the flu vaccine
-be in contact with other people who’ve had live vaccines as injections

Avoid contact with people who’ve had live vaccines taken by mouth (oral vaccines). This includes the rotavirus vaccine given to babies. The virus is in the baby’s urine for up to 2 weeks and can make you ill. So, avoid changing their nappies for 2 weeks after their vaccination if possible. Or wear disposable gloves and wash your hands well afterwards.

You also need to avoid anyone who has had oral polio or typhoid vaccination recently.


Further instructions

XALKORI powder(Crizotinib powder) is an oral receptor tyrosine kinase inhibitor. The molecular formula for Crizotinib powder is C21H22Cl2FN5O. The molecular weight is 450.34 daltons. Crizotinib powder is described chemically as (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)-1H-pyrazol-4-yl]pyridin-2-amine.

Crizotinib powder is a white to pale-yellow powder with a pKa of 9.4 (piperidinium cation) and 5.6 (pyridinium cation). The solubility of Crizotinib powder in aqueous media decreases over the range pH 1.6 to pH 8.2 from greater than 10 mg/mL to less than 0.1 mg/mL. The log of the distribution coefficient (octanol/water) at pH 7.4 is 1.65.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using Crizotinib powder and call your doctor at once if you have a serious side effect such as:

severe dizziness, fainting, fast or pounding heartbeats;
vision problems such as blurred vision, increased sensitivity of your eyes to light, or seeing flashes of light or “floaters”;
chest pain, dry cough or cough with mucus, wheezing, feeling short of breath;easy bruising, unusual bleeding…


Crizotinib powder Raw Powder

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order(Within 1kg)can be sent out in 3 workingdays after payment.


Crizotinib powder Marketing

To be provided in the coming future.



How to buy Crizotinib powder from AASraw


1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.