Guggulsterone powder (95975-55-6) hplc≥98% | AASraw R&D Reagents
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Guggulsterone powder

Rating: SKU: 95975-55-6. Category:

AASraw is with synthesis and production ability from gram to mass order of Guggulsterone powder (95975-55-6), under CGMP regulation and trackable quality control system.

Product Description


Guggulsterone powder video




Raw Guggulsterone powder basic Characters


Name: Guggulsterone powder
CAS: 95975-55-6
Molecular Formula: C21H28O2
Molecular Weight: 312.45
Melt Point: 170-171.5°C
Storage Temp: 2-8°C
Color: Light yellow powder



Raw Guggulsterone powder in usage



Devadhupa, Balsamodendrum wightii, Balsamodendrum mukul, Commiphora mukul, Commiphora wightii, Gomme Guggul, Gomme-Résine de Guggul, Guggal, Guggul Gum Resin, Guggul Lipids, Guggulipid, Guggulipide, Guggulu, Guggulu Suddha, Guggulsterone powder, etc


Guggulsterone powder Usage

Guggulsterone powder is a phytosteroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone powder can exist as either of two stereoisomers, E-Guggulsterone powder and Z-Guggulsterone powder. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of Guggulsterone powder, and levels of low-density lipoprotein (“bad cholesterol”) increased in many people. Nevertheless, Guggulsterone powder is an ingredient in many nutritional supplements.

Oleogum resin (known as guggul) from the guggul tree, Commiphora mukul, found in India, Bangladesh, and Pakistan, has been used to treat various diseases including hyper-cholesterolemia, atherosclerosis, rheumatism, and obesity over several thousands of years. Guggulsterone powder isolated from guggul has been identified as the bioactive constituent responsible for guggul’s therapeutic effects. Since the first study demonstrating the therapeutic effects of guggul in an animal model in 1966, numerous preclinical and clinical trails have been carried out. Although differences in study design, methodological quality, statistical analysis, sample size, and subject population result in certain inconsistencies in the response to therapy, the cumulative data from in vitro, preclinical, and clinical studies largely support the therapeutic claims for guggul described in the ancient Ayurvedic text. However, future clinical studies with much larger size and longer term are required to confirm these claims. The cardiovascular benefits of the therapy are derived from the multiple pharmacological activities associated with guggul or Guggulsterone powder, notably its hypolipidemic, antioxidant, and antiinflammatory activities. It has been established that Guggulsterone powder is an antagonist at farnesoid x receptor (FXR), a key transcriptional regulator for the maintenance of cholesterol and bile acid homeostasis. The FXR antagonism by Guggulsterone powder has been proposed as a mechanism for its hypolipidemic effect. A recent study demonstrates that Guggulsterone powder upregulates the bile salt export pump (BSEP), an efflux transporter responsible for removal of cholesterol metabolites, bile acids from the liver. Such upregulation of BSEP expression by Guggulsterone powder favors cholesterol metabolism into bile acids, and thus represents another possible mechanism for its hypolipidemic activity. Guggulsterone powder has been found to potently inhibit the activation of nuclear factor-kappaB (NF-kappaB), a critical regulator of inflammatory responses. Such repression of NF-kappaB activation by Guggulsterone powder has been proposed as a mechanism of the antiinflammatory effect of Guggulsterone powder.

Who Needs It?
And What Are Some Symptoms Of Deficiency?

It made sense to me that if one could combine the fat burning effects of the thyroid hormones with that of the adrenergic hormones (e.g. adrenaline) something very dramatic would result. Also, interesting is the fact that ECA type stacks tend to decrease the amount of thyroid hormones circulating in the blood over time. Guggulsterone powders do a great job of inhibiting this reduction, thus keeping all physiological fat burning systems operating at a maximum level.

The final ways that Guggulsterone powders can benefit in the fight to burn fat is in ketogenic diets and growth hormone use. Over time, ketogenic diets tend to reduce the thyroid’s effectiveness by reducing the conversion of T4 to the more potent T3. Also, where Guggulsterone powders were taken daily for 3 months, they produced a progressive reduction in lesions in the majority of the patients. With tetracycline, the percentage reduction in the inflammatory lesions was 65.2% as compared to 68% with the Guggulsterone powders. As you can see, our friend Guggul is extremely potent at fighting acne.

Who can benefit from this? Hmmm!!! Well, as far as I can tell, nearly everyone. There is not a single person I know that would not like a better complexion. This is especially true for those on anabolic/androgenic steroids as these tend to increase the skin’s oiliness and potential for acne. Let me guess – nobody is laughing at Mr. Huggulee Guggulee! Indeed, he might have a funny name but in my book he’s a hero. Where else can you find a compound that will help you lose fat, improve your cholesterol profile, and at the same time improve your complexion? I’ve looked long and hard and have yet to find even one competitor.

How Much Should Be Taken?
And Are There Any Side Effects?

Oh yeah! Before I forget, the dosage one should take is 30-60mg three times per day with meals.

Always remember though to find a product which contains the high potency naturally extracted Guggul! My final advice then is to go out and find this guy, shake his hand, and then reap the host of benefits that he brings.


Warning on Guggulsterone powder

A yellowish resin extracted from the guggul plant contains substances called Guggulsterone powders and possibly others. Laboratory studies have found that Guggulsterone powders can change the metabolism of cholesterol by the liver. Guggulsterone powders may also increase the production of thyroid hormones and are commonly included in weight loss supplements for that purpose. Products containing guggul extracts should be taken with caution because of their risk of side effects.

For thousands of years, guggul resin has been used in traditional medicine to treat rheumatism, arthritis, neurological diseases, hemorrhoids, urinary disorders and skin diseases. Modern medicine has found evidence that Guggulsterone powders can act in the liver, correcting disorders of lipid metabolism such as high cholesterol. Through an unknown mechanism, Guggulsterone powders also increase the thyroid gland’s production of hormones, increasing energy utilization in the body.

Interactions with Medicines
Guggul extract should not be taken with warfarin, aspirin, nonsteroidal anti-inflammatory drugs or any other drugs that inhibit blood clotting. Guggul extract may increase the risk of severe or uncontrolled bleeding when taken with these drugs. Guggul extract may interact with synthetic thyroid hormones or other medications used to treat thyroid disorders. Taken together, guggul and thyroid medications can raise the risk of thyroid storm, a potentially life-threatening condition in which very large amounts of thyroid hormones are produced. Guggul extract may greatly reduce the effectiveness of the drugs propranolol or diltiazem.

Interaction with Disease
Those being treated for thyroid disorders, including both hypo- and hyperthyroidism, should consult their doctor before taking guggul extract. People with liver or kidney disease may not metabolize guggul extract normally and should not take it. In general, consult your doctor to determine whether guggul extract is safe for you.

Other Possible Side Effects
Little scientific information exists on the potential toxicity of guggul extract. It is unknown whether guggul is safe during pregnancy, but because of effects on thyroid hormones and lipid metabolism it should probably be avoided. Guggul extract may cause headache, nausea, gastrointestinal disturbances and rash. Allergic reactions to guggul extract have been reported.


Further instructions

Guggulsterone powder is a broad-spectrum ligand of steroid hormone receptors, and is known to possess the following activities:

Mineralocorticoid receptor antagonist (Ki = 39 nM)
Progesterone receptor partial agonist (Ki = 201 nM)
Glucocorticoid receptor antagonist (Ki = 224 nM)
Androgen receptor antagonist (Ki = 240 nM)
Estrogen receptor agonist (Ki > 5 μM; EC50 > 5 μM)
Farnesoid X receptor antagonist (IC50 = 5–50 μM)
Pregnane X receptor agonist (EC50 = 2.4 μM ((Z)-isomer))
Guggulsterone powder has been found in animal research to be orally active; it has an absolute bioavailability of 42.9% after oral administration in rats, with a half-life of around 10 hours in this species, indicating a good pharmacokinetic profile.


Guggulsterone Raw Powder

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order(Within 1kg)can be sent out in 3 workingdays after payment.

Raw Guggulsterone powder Marketing

To be provided in the coming future.



How to buy Guggulsterone powder from AASraw


1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.