J 147 powder (1146963-51-0) | neuroprotective and neurotrophic compound
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J 147 powder

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AASraw is the professional manufacturer of pure J147 Powder which has independent lab and large factory as support, all production will be carried out under CGMP regulation and trackable quality control system. The supply system is stable, both retail and wholesale orders are acceptable.Welcome to order from AASraw!

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Product Description

1. J147 Powder video-AASraw

 


2. J147 Powder Basic Characters

Name: J 147 powder
CAS: 1146963-51-0
Molecular Formula: C18H17F3N2O2
Molecular Weight: 350.3349896
Melt Point: 177-178°C
Storage Temp: 4°C
Color: White or off white powder

 


3. J147 Powder Testing Report-HNMR

J 147 powder HNMR

What is HNMR and What does HNMR spectrum tell you? H Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.

4. What is J147 Powder?

J147 Powder is a synthetic derivative of curcumin, which is a component of the curry spice turmeric.  J147 Powder is essentially a Curcumin and Cyclohexyl-Bisphenol A (CBA) derivative that is both neurogenic and neuroprotective.

J147 Powder has been shown to significantly improve cognitive impairment in elderly Alzheimer’s patients. These findings are based on accelerated aging animal models. J147 Powder is an orally active neurotrophic medication that reverses cognitive impairment.

Curcumin is a polyphenol that is found in turmeric and ginger.

Curcumin has several demonstrated benefits in the treatment of different diseases, however there are evident limitations due to its weak capacity to pass the Blood-Brain Barrier (BB).

J147 Powder can cross the BBB into the brain (strong) and induce neuronal stem cell production.

J147 Powder, unlike the current Alzheimer’s Disease medications, is neither an acetylcholinesterase inhibitor nor a phosphodiesterase inhibitor, but it improves cognition with a short-term treatment.

This nootropic is gaining popularity as a treatment for Alzheimer’s disease. J-147 Powder has also caught the interest of healthy users due to its potential for memory enhancement, increased learning ability, and overall brain health. The user who look for buying J147 Powder, should buy it with the original manufacturer, so that you can get the factory J-147 powder price to save money.

5. How does J-147 works?

J-147’s impact on cells was unknown until Salk Institute neurobiologists solved the puzzle in 2018. J-147 works by binding to ATP synthase. This mitochondrial protein controls the aging process by modulating the generation of cellular energy. The presence of the J-147 Powder in the human system avoids age-related toxicities caused by dysfunctional mitochondria and overproduction of ATP.

The mechanism of action of J-147 Powder will also increase the levels of various neurotransmitters such as NGF and BDNF. Furthermore, it reduces beta-amyloid levels, which are always elevated in Alzheimer’s and dementia patients. J-147 effects include reducing the progression of Alzheimer’s disease, decreasing memory loss, and increasing neuronal cell creation.

Several studies with J-147 Powder have been conducted in mice. A human trial was carried out in 2020, however, full results have not yet been shared.

6. Benefits of J147 Powder

Enhances Mitochondrial Function And Life span

J147 Powder is highly efficient at reducing oxidative stress and enhancing mitochondrial performance.

For example, J147 Powder increases mitochondrial function by improving ATP levels (inhibiting ATP synthase, specifically ATP5A).

J147 Powder can lessen harmful metabolites that lead to excitotoxicity by inhibiting ATP synthase.

On a biochemical level, this promotes more youthful/healthy mitochondria (by modifying the AMPK/mTOR pathway).

 Prevents Alzheimer’s Disease

J147 Powder cures cognitive impairment in an Alzheimer’s disease mice model (AD).

J147 Powder can promote Amyloid-Beta (A) metabolism and reduce levels in the brain by lowering -Secretase protein levels (BACE).

J147 Powder can protect BBB permeability homeostasis and improve vascular function in animal models of Alzheimer’s disease.

J147 Powder can also considerably raise Docosahexaenoic Acid (DHA) levels in the brain.

It can help restore Glutamate levels in the brain (which are produced from the TCA intermediate -ketoglutarate).

Improves Memory

It improves cognition in both Alzheimer’s disease mice and normal-aged animal models.

J147 Powder can restore significant cognitive impairments in even the most elderly animal models.

J-147 can also help with spatial memory and Long-Term Potentiation (LTP).

Brain Growth

J 147 Powder has the ability to enhance and stimulate synaptic plasticity in the brain.

J 147 Powder promotes synaptic plasticity by maintaining Synaptophysin expression (a synaptic vesicle protein that is reduced in both aging and AD and is considered a biomarker for synapse loss).

J-147 Powder promotes brain growth by boosting levels of Nerve Growth Factor (NGF) and Brain-Derived Neurotrophic Factor (BDNF) (BDNF).

Protects Neurons

J 147 Powder does not require BDNF to be neuroprotective.

J 147 Powder also protects neurons from glutathione (GSH) deficiency.

J-147 Powder protects the brain against glucose deprivation.

In AD brains, 5-Lipoxygenase (5-LOX) recruits more immune cells to cause an inflammatory response, and Heme Oxygenase 1 (HO-1) acts as a pro-oxidant rather than an antioxidant.

Curcumin derivative J147 Powder has the ability to lower HO-1 levels as well as inhibit 5-LOX.

May Improve Diabetes

In animal models, J147 Powder has shown to decrease blood Glucose and HbA1c levels by increasing AMPK.

Although not significant, J147 Powder may also enhance the function of residual beta cells in diabetes.

Fights Pain And Neuropathy

J-147 Powder was proven to be efficacious in treating Diabetic Neuropathy in an animal model with type 1 diabetes.

It could help reduce diabetes-induced motor nerve dysfunction, peripheral sensitivity, and pain levels.

⑧May Improve Anxiety

J147 Powder has the ability to reduce anxiety levels.

J147 Powder was able to reduce anxiety levels during maze tests in animal models with AD.

7. J147 Powder dose and stack

Different studies have used different dosages on mice, but one of the better-reviewed studies gave mice 10 mg/kg of body weight per day. Another study used dosages of 1, 3 or 9 mg/kg, and found dose-dependent effects, with the higher dosages working better.

However, translating this to a human dosage requires adjusting for body surface area. According to the most commonly-used conversion formula, a human-equivalent dose should equal the mouse dosage divided by 12.3–or .81 mg per kg of bodyweight per day.

Some of the benefits will become evident as soon as you begin using it. Even with short-term therapy, J-147 elicits fast antidepressant-like effects in rats over a 3-day period without establishing drug tolerance or increased cognition. There are many J147 Powder for sale online, it is important to buy real and high quality product. You can buy J147 Powder Wholesale with supplier AASRAW.

J147 has not been popular amongst healthy individuals for long enough for us to confidently recommend any stacks. Not all nootropics can be ‘mix and matched’ safely.

8. J147 Powder human trials and user experiences

The first J147 Powder human study has been registered and is expected to be finished in 2020. It appears to have been undertaken as a phase 1 trial on 64 healthy persons, with the primary goal of examining the safety and pharmacokinetics (half-life, side effects, tissue concentrations) of J147 Powder, rather than its usefulness in treating any condition.

Although the findings of this study have not yet been made public, we do know that it appeared to be completed without significant problems.

Although J147 Powder is a research chemical and has been discussed in several nootropics communities, there haven’t been many user reports given thus far, and many people are waiting to see further study before using it. According to J-147 Powder users, It is easy to buy J147 powder online, finding a realiable J147 Powder supplier will spend some certain times. AASRAW supplier supplies high quality J-147 Powder. If you make J-147 supplements, you can buy J147 Powder bulk to enjoy the good price.

The majority of people appear to observe no discernible effects out of the few user experiences that have been reported. Although the users tend to be young and healthy and the period of usage is typically considerably shorter than in studies, curcumin derivative J147 Powder may not have particularly significant nootropic effects on healthy young adults.

We can only make educated guesses as to how useful J147 Powder would be in the absence of human research or popular anecdotes. In theory, anything that increases neuronal energy metabolism ought to have nootropic effects, however your cognitive function may not truly be limited by energy consumption. It can depend on how quickly nutrients can enter and exit your brain or how nicely your thoughts are put together.

Curcumin derivative J147 Powder also produces a lot more neurotrophic factors, which means it might be able to assist your brain develop more synapses and brain cells. But keep in mind that there can be an excess of synapses and brain cells.

There is currently no reason to believe that J147 Powder will have a significant nootropic impact on young, healthy adults. For those who have dementia, it most likely is beneficial. In slightly older persons who are aware that dementia runs in their family, it may be helpful as a nootropic since it may stop or reverse cognitive loss before it develops into clinical dementia. In any case, it will be a while before we are certain.

9. J-147 Powder risks and side effects

J147 Powder has been clinically examined and found to be safe for long-term usage by independent labs. It passed the toxicological testing in animal studies that the Food and Drug Administration (FDA) requires, and no negative effects have been documented in humans when taken at the recommended dosage (discussed later).

10. Where to buy J-147 Powder?

The legality of this nootropic is still being debated, however it will not prevent you from purchasing legitimate items. After all, clinical trials for J-147 Alzheimer’s are already underway. You may buy the powder from online stores since you can compare J-147 Powder prices from many sellers. However, you should browse around for a reputable manufacturer with independent laboratory testing.

If you want some J-147 Powder for sale, check in with our factory. We provide a wide range of nootropics under strict quality control. Depending on your psychonautic goal, you can buy in bulk or individually. Note that, J-147 Powder price is friendly only when you buy in wholesale quantity.

11.References

[1] Pan X, Chen L, Xu W, Bao S, Wang J, Cui X, Gao S, Liu K, Avasthi S, Zhang M, Chen R. “Activation of monoaminergic system contributes to the antidepressant- and anxiolytic-like effects of J147.” Behav Brain Res. 2021 Aug 6;411:113374. doi: 10.1016/j.bbr.2021.113374. Epub 2021 May 21. PMID: 34023306

[2] Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. “Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling.”Front Neurosci. 2020 Jul 8;14:701. doi: 10.3389/fnins.2020.00701. eCollection 2020.PMID: 32733195

[3] Jin R, Wang M, Zhong W, Kissinger CR, Villafranca JE, Li G. “J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats.”Front Neurol. 2022 Mar 2;13:821082. doi: 10.3389/fneur.2022.821082. eCollection 2022. PMID: 35309561

[4] Emmanuel IA, Olotu FA, Agoni C, Soliman MES. “In Silico Repurposing of J147 for Neonatal Encephalopathy Treatment: Exploring Molecular Mechanisms of Mutant Mitochondrial ATP Synthase.” Curr Pharm Biotechnol. 2020;21(14):1551-1566. doi: 10.2174/1389201021666200628152246. PMID: 32598251

[5] Lian L, Xu Y, Zhang J, Yu Y, Zhu N, Guan X, Huang H, Chen R, Chen J, Shi G, Pan J. “Antidepressant-like effects of a novel curcumin derivative J147: Involvement of 5-HT1A receptor.” Neuropharmacology. 2018 Jun;135:506-513. doi: 10.1016/j.neuropharm.2018.04.003. Epub 2018 Apr 5. PMID: 29626566

12. How to buy J147 Powder from AASraw?

❶To contact us by our email inquiry system,or leave your whatsapp number to us, our customer service representative(CSR) will contact with you in 12 hours.

❷To provide us your inquired quantity and address.

❸Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).

❹Payment done and the goods will be sent out in 12 hours.

❺Goods received and give comments.


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