JJKK 048

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AASraw is with synthesis and production ability from gram to mass order of JJKK 048 powder (1515855-97-6), under CGMP regulation and trackable quality control system.

Product Description

 

JJKK 048 video

 

 


 

JJKK 048 basic Characters

 

Name: JJKK 048
CAS:  1515855-97-6
Molecular Formula:  C23H22N4O5
Molecular Weight:  434.44
Melt Point:
Storage Temp: -20°C
Color: White solid

 


 

JJKK 048 cycle

 

Names

Chemical Name: 4-[Bis(1,3-benzodioxol-5-yl)methyl]-1-piperidinyl]-1H-1,2,4-triazol-1-yl-methanone
Synonyms:
JJKK 048; MolPort-035-941-193; BDBM50065646; AKOS025142062; ZINC103287208; [4-[bis(1,3-benzodioxol-5-yl)methyl]piperidin-1-yl]-(1,2,4-triazol-1-yl)methanone

 

JJKK 048 Usage

Monoacylglycerol lipase (MAGL) terminates the signaling function of the endocannabinoid, 2-arachidonoylglycerol (2-AG). During 2-AG hydrolysis, MAGL liberates arachidonic acid, feeding the principal substrate for the neuroinflammatory prostaglandins.In cancer cells, MAGL redirects lipid stores toward protumorigenic signaling lipids. Thus MAGL inhibitors may have great therapeutic potential. Although potent and increasingly selective MAGL inhibitors have been described, their number is still limited.Here, we have characterized piperazine and piperidine triazole ureas that combine the high potency attributable to the triazole leaving group together with the bulky aromatic benzodioxolyl moiety required for selectivity, culminating in compound JJKK-048 that potently (IC50 < 0.4 nM) inhibited human and rodent MAGL. JJKK-048 displayed low cross-reactivity with other endocannabinoid targets. Activity-based proteinprofiling of mouse brain and human melanoma cell proteomes suggested high specificity also among the metabolic serine hydrolases.

 

What is the dosage of JJKK 048

DMSO to 100 mM
Stability and Solubility Advice:
Some solutions can be difficult to obtain and can be encouraged by rapid stirring, sonication or gentle warming (in a 45-60°C water bath).Information concerning product stability, particularly in solution,has rarely been reported and in most cases wecan only offer a general guide. Our standard recommendations are: SOLIDS: Provided storage is as stated on the product label andthe vial is kept tightly sealed, theproduct can be stored for up to 6 months from date of receipt. SOLUTIONS: We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Wherever possible solutions
should be made up and used on the same day.

 

How JJKK 048 works

In Vivo Characterization of the Ultrapotent Monoacylglycerol Lipase Inhibitor {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048).
Monoacylglycerol lipase (MAGL) is a serine hydrolase that acts as a principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). In addition to terminating the signaling function of 2-AG, MAGL liberates arachidonic acid to beused as a primary source for neuroinflammatory prostaglandin synthesis in the brain. MAGL activity also contributes to cancer pathogenicity by producing precursors for tumor-promoting bioactive lipids. Pharmacological inhibitors of MAGL provide valuable tools for characterization of MAGL and 2-AG signaling pathways. They also hold great therapeutic potential to treat several pathophysiological conditions, such as pain, neurodegenerative disorders, and cancer. We have previously reported piperidine triazole urea, {4-[bis-(benzo[d][1,3]dioxol-5-yl)methyl]-piperidin-1-yl}(1H-1,2,4-triazol-1-yl)methanone (JJKK-048), to be an ultrapotent and highly selective inhibitor of MAGL in vitro. Here, we characterize in vivo effects of JJKK-048. Acute in vivo administration of JJKK-048 induced a massive increase in mouse brain 2-AG levels without affecting brain anandamide levels. JJKK-048 appeared to be extremely potent invivo. Activity-based protein profiling revealed that JJKK-048 maintains good selectivity toward MAGL over other serine hydrolases. Our results are also the first to showthat JJKK-048 promoted significant analgesia in a writhing test with a low dose thatdid not cause cannabimimetic side effects. At a high dose, JJKK-048 induced analgesia both in the writhing test and in the tail-immersion test, as well as hypomotilityand hyperthermia, but not catalepsy.

 

Warning

5.1 Please note that tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due toslight batch-to-batch variations.
5.2 Exposure controls and personal protection: In case of skin contact, eye contact,inhaled,swallowed,consult a doctor if any discomfort.
5.3 Most important symptoms and effects, both acute and delayed
To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly investigated.
5.4 Indication of immediate medical attention and special treatment needed, call thedoctor immediately.
5.5 Precautions for safe handling,use in a chemical fume hood, with air supplied byan independent system. Avoid inhalation, contact with eyes, skin and clothing. Avoidthe formation of dust and aerosols. Use in a well-ventilated area. Keep away fromsources of ignition. Avoid prolonged or repeated exposure.
5.6 Conditions for safe storage, including any incompatibilities.
Store in cool, well-ventilated area. Keep away from direct sunlight. Keep container tightly sealed until ready for use. Recommended storage temperature: Store at +4°C
5.7 Specific end uses: Use in a laboratory fume hood where possible.

 

JJKK 048

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.

JJKK 048 Marketing

To be provided in the coming future.

 

Does JJKK 048 Have Any Side Effects

To the best of our knowledge, the chemical, physical and toxicological properties have not been thoroughly investigated.

 


 

How to JJKK 048 powder (1515855-97-6) from AASraw

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


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COA

COA 1515855-97-6 JJKK 048 AASRAW

COA 1515855-97-6 JJKK 048 AASRAW

HNMR

Recipes

JJKK 048 Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

References & product citations

MAGL inhibitor JJKK-048 suppliers online

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