Raw JW 642 (1416133-89-5) suppliers hplc≥98% | AASraw

JW 642

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. JW 642 is a potent inhibitor of monoacylglycerol lipase (MAGL) that displays IC50 values of 7.6, 14, and 3.7 nM forinhibition of MAGL in mouse, rat, and human brain membranes, respectively. JW642is selective for MAGL, requiring much higher concentrations to effectively inhibit fatty acid amide hydrolase activity (IC50s = 31, 14, and 20.6 µM for mouse, rat, andhuman brain membranes, respectively).

Product Description

 

JW 642 video

 

 


 

I.JW 642 basic Characters:

 

Name: JW 642
CAS: 1416133-89-5
Molecular Formula: C21H20F6N2O3
Molecular Weight: 462.4
Melt Point:
Storage Temp: at -20°C 3 years Powder
Color: White solid

 


 

II. JW 642 cycle

 

1. Names:

Chemical Names:
4-[(3-Phenoxyphenyl)methyl]-1-piperazinecarboxylic acid 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Synonyms:
JW 642;1,1,1,3,3,3-Hexafluoropropan-2-yl 4-(3-phenoxybenzyl)piperazine-1-carboxylate

 

2. JW 642 Usage:

In laboratory procedures,for long term storage,we suggest that JW 642be stored assupplied at -20℃. It should be stable for at least one year.
JW 642 is supplied as a solution in methyl acetate. To change the solvent,simply evaporate the methyl acetate under a gentle stream of nitrogen and immediately addthe solvent of the choice. Solvents such asethanol,DMSO,and dimethyl formamide purged with an inert gas can be used. The solubility of JW 642 in these solvents isapproximately 13,5,and 11mg/ml,respectively.
JW 642 is sparingly soluble in aqueous buffers. For maximum solubility in aqueousbuffers,the ethanolic solution of JW 642should be diluted with the aqueous buffer ofchoice. JW 642 has a solubility of approximately 0.3 mg/ml in a 1:2 solution of ethanol:PBS(pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

 

3.What is the dosage of JW 642 ?

DMSO to 100 mM
Ethanol to 100 mM
Stability and Solubility Advice: Some solutions can be difficult to obtain and can beencouraged by rapid stirring, sonication or gentle warming (in a 45-60°C water bath). Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. Our standard recommendations are: SOLIDS: Provided storage is as stated on the product label and the vial is kept tightly sealed, the product can be stored for up to 6 months from date of receipt. SOLUTIONS: We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vialsat -20°C or below and used within 1 month.Wherever possible solutions should be made up and used on the same day.

 

4.How JW 642 works?

JW 642 is a potent and selective monoacylglycerol lipase (MAGL) inhibitor (IC = 3.7 nM). Displays >1000-fold selectivity for MAGL over fatty acid amidehydrolase (IC = 20.6 μM). Monoacylglycerol lipase (MAGL) isa serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function. Toxicological Effects may be caused like below: Methyl Acetate – Toxicity Data: Oral LD50 (rat): >5,000 mg/kg; Oral LD50 (rabbit): 3,705 mg/kg; Skin LD50(rabbit): >5,000 mg/kg; Inhalation TCLO (human): 15,000 mg/m3; Methyl Acetate – Irritation Data: Skin (rabbit): 500 mg (24h) mild; Eyes (rabbit):100 mg (24h)moderate.

 

5.Warning:

I.Stability and reactivity

5.1 Reactivity

Stable under recommended transport or storage conditions.

5.2 Chemical stability

Stable under recommended storage conditions.

5.3 Possibility of hazardous reactions

Hazardous reactions will not occur under normal transport or storage conditions. Decomposition may occur on exposure to conditions or materials listed below.

5.4 Conditions to avoid heat, moisture.
5.5 Incompatible materials

Strong acids/alkalis, strong oxidising/reducing agents.

5.6 Hazardous decomposition products

In combustion may emit toxic fumes. No known decomposition information.

II.Handing and storage

5.1 Precautions for safe handling

Use in a chemical fume hood, with air supplied by an independent system. Avoid inhalation, contact with eyes, skin and
clothing. Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid
prolonged or repeated exposure.

5.2 Conditions for safe storage, including any incompatibilities.

Store in cool, well-ventilated area. Keep away from direct sunlight. Keep container tightly sealed until ready for use.
Recommended storage temperature: Store at -20°C

5.3 Specific end uses

Use in a laboratory fume hood where possible.

 

6.JW 642 Raw Powder:

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.

 

7.JW 642 Raw Powder Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

8.JW 642 Marketing:

To be provided in the coming future.

 

9.Does JW 642 Have Any Side Effects?

Material may be irritating to the mucous membranes and upper respiratory tract; May be harmful by inhalation, ingestion, or skin absorption; May cause drowsiness ordizziness; May cause skin or respiratory system irritation. Repeated exposure may cause skin dryness or cracking.
Exposure controls/personal protection

9.1 Control parameters

Components with workplace control parameters
Contains no substances with occupational exposure limit values.

9.2 Exposure controls

Appropriate engineering controls
Use in a fume hood where applicable. Ensure all engineering measures described under section 7 of SDS are in place.
Ensure laboratory is equipped with a safety shower and eye wash station.
Personal protective equipment

Eye/face protection
Use appropriate safety glasses.
Skin protection
Use appropriate chemical resistant gloves (minimum requirement use standard BS EN 374:2003). Gloves should be
inspected before use. Wash and dry hands thoroughly after handling.
Body protection
Wear appropriate protective clothing.
Respiratory protection
If risk assessment indicates necessary, use a suitable respirator.

al among others

 


 

III. JW 642 HNMR

 

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IV. How to buy JW 642 from AASraw?

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


 

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