KML29 suppliers (1380424-42-9) hplc≥99% | AASraw MAGL inhibitor

KML29

KML-29 with gabapentin synergistically produces analgesia in mice. Solubility: Chloroform (Slightly, Heated, Sonicated), Methanol (Slightly, Heated) Applications:KML-29 is an extremely specific monoacylglycerol lipase (MAGL) inhibitor. KML-2 should be useful to distinguish between actions of 2-arachidonoyl glycerol (an endogenous ligand of cannabinoid receptors that is deactivated by MAGL) and anandamide, another endocannabinoid. In vivo characterization of the highly selective monoacylglycerol lipase inhibitor KML29:antinociceptive activity without cannabimimetic side effects.

Product Description

 

KML29 video

 

 


 

I.KML29 basic Characters:

 

Name: KML29
CAS: 1380424-42-9
Molecular Formula: C24H21F6NO7
Molecular Weight: 549.42
Melt Point: 204-206°C
Storage Temp: Store at -20°C
Color: White crystalline solid

 


 

II. KML29 cycle

 

1.Names:

Chemical Names:1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate 1-piperidinecarboxylic acid2,2,2-trifluoro-1-(trifluoromethyl)ethyl ester
Synonym: KML-29; KML29; KML 29.

 

2.How KML29 works?

We do an experiment reseach as below:
For In the present study, we tested KML29 in murine inflammatory (i.e. carrageenan) and sciatic nerve injury pain models, as well as the diclofenac-induced gastric haemorrhage model. KML29 was also evaluated for cannabimimetic effects, including measurements of locomotor activity, body temperature, catalepsy, and cannabinoid interoceptive effects in the drug discrimination paradigm. Since monoacylglycerol lipase (MAGL) has been firmly established as the predominant catabolic enzyme of the endocannabinoid 2-arachidonoylglycerol (2-AG), a great need has emerged for the development of highly selective MAGL inhibitors. Here, we tested the in vivo effects of one such compound, KML29 (1,1,1,3,3,3-hexafluoropropan-2-yl 4-(bis(benzo[d][1,3]dioxol-5-yl)(hydroxy)methyl)piperidine-1-carboxylate).We get the key results: KML29 attenuated carrageenan-induced paw oedema and completely reversed carrageenan-induced mechanical allodynia. These effects underwent tolerance after repeatedadministration of high-dose KML29, which were accompanied by cannabinoid receptor 1 (CB1 ) receptor desensitization. Acute or repeated KML29 administration increased 2-AG levels and concomitantly reduced arachidonic acid levels, but without elevating anandamide (AEA) levels in the whole brain. Furthermore, KML29 partially reversed allodynia in the sciatic nerve injury model and completely prevented diclofenac-induced gastric haemorrhages. CB1 and CB2 receptors played differential rolesin these pharmacological effects of KML29. In contrast, KML29 did not elicit cannabimimetic effects, including catalepsy, hypothermia and hypomotility. Although KML29did not substitute for Δ(9) -tetrahydrocannabinol (THC) in C57BL/6J mice, it fullyand dose-dependantly substituted for AEA in fatty acid amide hydrolase (FAAH) (-/-) mice, consistent with previous work showing that dual FAAH and MAGL inhibitionproduces THC-like subjective effects.These results indicate that KML-29, a highly selective MAGL inhibitor, reduces inflammatory and neuropathic nociceptive behaviourwithout occurrence of cannabimimetic side effects.

 

3.Shipping Condition

Shipped under ambient temperature as non-hazardous chemical.This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 – 4 C for short term (days to weeks) or-20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 – 4 C for short term (days to weeks), or -20 C for long term (months).

 

4.Warning:

Exposure controls
Engineering controls
Ensure adequate ventilation. Provide accessible safety shower and eye wash station.
Personal protective equipment
Eye protection Safety goggles with side-shields.
Hand protection Protective gloves.
Skin and body protection Impervious clothing.
Respiratory protection Suitable respirator.
Environmental exposure controls Keep the product away from drains, water coursesor the soil. Clean
spillages in a safe way as soon as possible.

 

5.ADDITIONAL INFORMATION

Endocannabinoids such as 2-arachidonoyl glycerol (2-AG) and arachidonoyl ethanolamide are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) isa serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid and glycerol, thus terminating its biological function.

 

6.KML29:

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.

 

7.KML29 Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

8.KML29 Marketing:

To be provided in the coming future.

 

9.Does KML-29 Have Any Side Effects?

 

9.1 Classification of the substance or mixture
Not a hazardous substance or mixture.

9.2 GHS Label elements, including precautionary statements
Not a hazardous substance or mixture.

9.3 Other hazards
None.

9.4 FIRST AID MEASURES(If the following symptoms occur)

9.5 Eye contact
Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids
with fingers to ensure adequate flushing. Promptly call a physician.

9.6 Skin contact
Rinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.

9.7 Inhalation
Immediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouthto-mouth
resuscitation.

9.8 Ingestion
Wash out mouth with water; Do NOT induce vomiting; call a physician.

 


 

III. KML-29 HNMR

 

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IV. How to buy KML-29 from AASraw?

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


 

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