Lapatinib powder

AASraw is with synthesis and production ability from gram to mass order of Lapatinib powder (231277-92-2), under CGMP regulation and trackable quality control system.

lapatinib powder is a cancer medicine that interferes with the growth and spread of cancercells in the body. lapatinib powder is used to treat a certain type of hormone-related breast cancer that has progressed or spread after treatment with other cancer medicines. In postmenopausal women, lapatinib powder is given in combination with a hormonal medicine called letrozole (Femara). In others, lapatinib powder is given together with a cancer medicine called capecitabine (Xeloda).

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Product Description

 

Lapatinib powder video

 

 


 

I.Lapatinib powder basic Characters:

 

Name: Lapatinib powder
CAS: 231277-92-2
Molecular Formula: C29H26ClFN4O4S
Molecular Weight: 581.05
Melt Point: 136-140°C
Storage Temp: Refrigerator
Color: White or off white Crystalline powder

 


 

II. Raw Lapatinib powder in Antineoplastic Agent cycle

 

1. Names:

Generic Name: Lapatinib powder (la PA tin ib)
Brand Name: Tykerb

 

2. Raw Lapatinib powder Usage:

Lapatinib powder is a prescription medication used with another medicine (capcitabine) to treat people with breast cancer that has spread to other areas of the body that is HER2 positive (tumors that produce large amounts of a protein called human epidermal growth factor receptor-2), and who have already had certain other breast cancer treatments.

Lapatinib powder is also used with a type of medicine called letrozole for the treatment of postmenopausal women with hormone receptor positive, HER2 positive metastatic breast cancer for whom hormonal therapy is indicated.

Lapatinib powder is a prescription medication used to treat breast cancer. It is used in combination with other medications to treat a certain type of breast cancer that has spread to other parts of the body and that has not responded to other cancer treatments.

Lapatinib powder belongs to a group of drugs called kinase inhibitors which work by blocking the action of a certain protein that signals cancer cells to multiply.

This medication comes in tablet form and is taken once daily on an empty stomach.

Common side effects of Lapatinib powder include red, painful hands and feet, diarrhea, rash,and nausea.

 

3.What is the dosage of Lapatinib powder?

Usual Adult Dose for Breast Cancer

-HER2-POSITIVE METASTATIC BREAST CANCER (in combination with capecitabine): 1250 mg orally once a day on Days 1 to 21 continuously in repeating 21-day cycles until disease progression or unacceptable toxicity.

-HORMONE RECEPTOR-POSITIVE, HER2-POSITIVE METASTATIC BREAST CANCER (in combination with letrozole): 1500 mg orally once a day continuously.

Comments:
-Consult the manufacturer product information for capecitabine and letrozole dosing recommendations.
-HER2-positive metastatic breast cancer patients should have disease progression on trastuzumab prior to initiation of treatment with this drug in combination with capecitabine.

Uses:
-In combination with capecitabine for treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 and who have received prior therapy including an anthracycline, a taxane, and trastuzumab.
-In combination with letrozole for treatment of postmenopausal women with hormone receptor-positive metastatic breast cancer that overexpresses the HER2 receptor for whom hormonal therapy is indicated.

Renal Dose Adjustments
Data not available regarding dosage adjustments; however, the pharmacokinetics of this drug are unlikely to be affected given that less than 2% of an administered dose is eliminated by the kidneys.

Liver Dose Adjustments
PRE-EXISTING MILD TO MODERATE HEPATIC IMPAIRMENT (CHILD-PUGH A/B): Data not available.

PRE-EXISTING SEVERE HEPATIC IMPAIRMENT (CHILD-PUGH C): Reduce dose:
-HER2-Positive Metastatic Breast Cancer (in combination with capecitabine): 750 mg/day.
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (in combination with letrozole): 1000 mg/day

SEVERE HEPATOTOXICITY OCCURS DURING THERAPY: Permanently discontinue treatment.

Comments: Dose adjustment recommendations are based on pharmacokinetic studies; there are no clinical data available.

Dose Adjustments
CONCOMITANT USE WITH STRONG CYP450 3A4 INHIBITORS AND/OR STRONG CYP450 3A4 INDUCERS: Avoid concomitant use if possible. Dose adjustment recommendations are based on pharmacokinetic studies; there are no clinical data available.
CONCOMITANT USE WITH STRONG CYP450 3A4 INHIBITOR: Reduce dose to 500 mg/day; allow washout period of approximately 1 week before upward adjustment of this drug to the usual recommended dose if inhibitor discontinued.
CONCOMITANT USE WITH STRONG CYP450 3A4 INDUCER: Gradually up-titrate dose based on tolerability; decrease dose back to the usual recommended dose if inducer discontinued.
-HER2-Positive Metastatic Breast Cancer (in combination with capecitabine): Increase dose up to 4500 mg/day.
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (in combination with letrozole): Increase dose up to 5500 mg/day.

GRADE 2 or GREATER DECREASED LEFT VENTRICULAR EJECTION FRACTION(LVEF) OR LVEF THAT DROPS BELOW INSTITUTION’S LOWER LIMIT OF NORMAL: Discontinue treatment; may restart at reduced dose after a minimum of 2 weeks if LVEF recovers to normal and patient is asymptomatic.
Reduced Doses:
-HER2-Positive Metastatic Breast Cancer (in combination with capecitabine): 1000 mg/day
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer (in combination with letrozole): 1250 mg/day

GRADE 3 OR GRADE 1 or 2 DIARRHEA WITH COMPLICATING FEATURES (moderate to severe abdominal cramping, Grade 2 or greater nausea or vomiting, decreased performance status, fever, sepsis, neutropenia, frank bleeding, or dehydration):May reintroduce at lower dose when diarrhea resolves to Grade 1 or less.
Reduced Doses:
-HER2-Positive Metastatic Breast Cancer Patients (in combination with capecitabine): 1000 mg/day
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Patients: 1250mg/day
GRADE 4 DIARRHEA: Permanently discontinue treatment.

OTHER TOXICITIES, GRADE 2 or GREATER: May consider discontinuation or interruption of dosing; may restart at the usual recommended dose when toxicity improves to Grade 1 or less.
IF TOXICITY RECURS: Reduce dose:
-HER2-Positive Metastatic Breast Cancer (in combination with capecitabine): 1000 mg/day
-Hormone Receptor-Positive, HER2-Positive Metastatic Breast Cancer Patients: 1250mg/day

 

4.How raw Lapatinib powder works?

Lapatinib powder is used with capecitabine (Xeloda) to treat a certain type of advanced breast cancer in people who have already been treated with other chemotherapy medications. Lapatinib powder is in a class of medications called kinase inhibitors. It works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps stop or slow the spread of cancer cells.

 

5.Warning:

Tell all of your health care providers that you take Lapatinib powder. This includes your doctors, nurses, pharmacists, and dentists.
If you have upset stomach, throwing up, loose stools (diarrhea), or are not hungry, talk with your doctor. There may be ways to lower these side effects.
Loose stools (diarrhea) have happened with Lapatinib powder. Sometimes, diarrhea has been very bad and deaths have happened. Talk with your doctor.
If you have loose stools (diarrhea), talk with your doctor. Do not try to treat diarrhea without first checking with your doctor.
Have blood work checked as you have been told by the doctor. Talk with the doctor.
You will need to have heart function tests while taking Lapatinib powder. Talk with the doctor.
Avoid grapefruit and grapefruit juice.
If you are taking digoxin, talk with your doctor. You may need to have your blood work checked more closely while you are taking it with Lapatinib powder.
This medicine may cause harm to the unborn baby if you take it while you are pregnant.
Use birth control that you can trust to prevent pregnancy while taking Lapatinib powder.
If you are pregnant or you get pregnant while taking Lapatinib powder, call your doctor rightaway.

 

6.Lapatinib Raw Powder:

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.

 

7.Lapatinib Raw Powder Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

8.Lapatinib powder Marketing:

To be provided in the coming future.

 

9.Does raw Lapatinib powder Have Any Side Effects?

Along with its needed effects, Lapatinib powder may cause some unwanted effects. Althoughnot all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking Lapatinib powder:

Less common
Difficult or labored breathing
fainting
fast or irregular heartbeat
severe diarrhea
tightness in the chest
unusual tiredness or weakness
Rare

 

Abdominal or stomach pain or tenderness
clay colored stools
dark urine
decreased appetite
fever
headache
itching or skin rash
loss of appetite
nausea and vomiting
swelling of the feet or lower legs
yellow eyes or skin
Incidence not known
Blistering, peeling, loosening of the skin
chest pain
chills
cough
diarrhea
difficulty with swallowing
dizziness
general feeling of discomfort or illness
hives
joint or muscle pain
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
red skin lesions, often with a purple center
red, irritated eyes
sore throat
sores, ulcers, or white spots in the mouth or on the lips
thickening of bronchial secretions
Some side effects of Lapatinib powder may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

 

More common
Acid or sour stomach
back pain
belching
cracked lips
diarrhea (mild)
dry skin
heartburn
indigestion
pain in the arms or legs
redness, swelling, or painful skin
scaling of the skin on the hands and feet
sores, ulcers, or white spots on the lips, tongue, or the inside of the mouth
stomach discomfort, upset, or pain
swelling or inflammation of the mouth
tingling of the hands and feet
trouble sleeping

 


 

III. Lapatinib powder HNMR

 

We are Lapatinib powder supplie,Lapatinib powder for sale,Raw Lapatinib powder (231277-92-2) hplc≥98% | AASraw R&D Reagents

 


 

IV. How to buy Lapatinib powder from AASraw?

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


 

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