Lorcaserin (Belviq) powder (616202-92-7) hplc≥98% | AASraw
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Lorcaserin powder

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Product Description


Lorcaserin Introduction

Producing an efficient and safe weight loss drug is a daunting task. Attempts in the past have come with several side effects such as heart damage. Luckily, a new study says that lorcaserin weight loss pill can assist you shed off excess weight without having to sacrifice the health of your heart. Lorcaserin is a wonder appetite suppressant pill, which was approved by FDA in 2012. But what is lorcaserin? Well, below is an in-depth description of the drug, its chemical structure and properties, uses, dosage, precautions, and much more.

Product Name: Lorcaserin/ BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine


Lorcaserin(Belviq) powder video




I.Lorcaserin(Belviq) powder basic Characters:


Name: Lorcaserin(Belviq) powder
CAS: 616202-92-7
Molecular Formula:  C11H14ClN
Molecular Weight: 195.692
Melt Point: 212°C
Storage Temp: RT
Color: White to off-white powder



Lorcaserin Introduction

Producing an efficient and safe weight loss drug is a daunting task. Attempts in the past have come with several side effects such as heart damage. Luckily, a new study says that lorcaserin weight loss pill can assist you shed off excess weight without having to sacrifice the health of your heart. Lorcaserin is a wonder appetite suppressant pill, which was approved by FDA in 2012. But what is lorcaserin? Well, below is an in-depth description of the drug, its chemical structure and properties, uses, dosage, precautions, and much more.

Product Name: Lorcaserin/ BELVIQ (lorcaserin hydrochloride)

IUPAC Name: (5R)-7-chloro-5-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine


Below is the chemical structure of lorcaserin in 3-D conformation.

Lorcaserin(Belviq) powder


Chemical Properties of Lorcaserin (belviq) (CAS 616202-92-7)

Below is the summarized chemical properties of Lorcaserin (belviq);  they have been presented in the table below for a quick glance.


Property Name Property Value
Covalently-Bonded Unit Count 1
Isotope Atom Count 0
Undefined Bond Stereocenter Count 0
Defined Bond Stereocenter Count 0
Undefined Atom Stereocenter Count 0
Defined Atom Stereocenter Count 1
Heavy Atom Count 13
Formal Charge 0
Compound Is Canonicalized True
XLogP3-AA 2.7
Exact Mass 195.081 g/mol
Monoisotopic Mass 195.081 g/mol
Topological Polar Surface Area 12 A^2
Complexity 172
Rotatable Bond Count 0
Hydrogen Bond Acceptor Count 1
Hydrogen Bond Donor Count 1
Molecular Weight 195.69 g/mol
Dissociation Constants


pKa = 9.98 (est)


A simple description of the Lorcaserin HCL powder

Lorcaserin (Belviq) is an appetite suppressant pill formulated by Arena Pharmaceuticals.  It belongs to a class of drugs referred to as serotonin receptor agonists. It’s designed to help you feel full after you have eaten less food. It suppresses appetite by activating the 5-HT2C receptors, which are types of serotonin receptors in a region of the brain (hypothalamus) that controls appetite. When they signal your body to feel full, you get to eat less, thus end up losing weight in the long run.

Belviq, whose chemical name is (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3- benzazepine hydrochloride hemihydrate, is meant to be taken orally. Its molecular weight is 241.16 g/mol, and its empirical formula is C11H15Cl2N•0.5H2O. Its structural formula is hereunder:


Lorcaserin(Belviq) powder


The solubility of Lorcaserin hydrochloride hemihydrate in water is higher than 400 mg/mL.  A Belviq tablet has 10.4 milligrams of crystalline lorcaserin hydrochloride hemihydrate (a white to off-white powder), which is equal to 10.0 milligrams anhydrous lorcaserin hydrochloride. It also contains other ingredients, including magnesium stearate NF, talc USP, FD&C Blue #2 aluminum lake, titanium dioxide USP, polyethylene glycol NF, polyvinyl alcohol USP, colloidal silicon dioxide NF, croscarmellose sodium NF, silicified microcrystalline cellulose and hydroxypropyl cellulose NF.


The action of mechanism of Lorcaserin

According to the Food and Drug Administration’s guidance criteria (2007), Lorcaserin is capable of helping adults achieve clinically meaningful weight loss. This weight loss drug is said to work well when paired with increased physical activity as well as a low-calorie diet. It can significantly help with chronic weight management, especially with people who are overweight (at least 27 kg/m2), or obese (BMI of at least30 kg/m2). This medication can also help those with one or more weight-related issues, such as type 2 diabetes, dyslipidemia, or hypertension.

Lorcaserin is a novel appetite suppressant pill that acts selectively as a 5-HT2C receptor agonist in the hypothalamus with action selectivity of fifteen times more affinity for 5-HT2C  receptors than for 5-HT2A  and a whopping a 100 times higher functional selectivity for 5-HT2C receptors than for the 5-HT2B.

5-HT2C receptors are situated almost exclusively in the human brain and can be found in the thalamus, hypothalamus, cortex, hippocampus, choroid plexus,  cerebellum, and amygdala. The stimulation of 5-HT2C receptors in the hypothalamus activates POMC (proopiomelanocortin) production and therefore promote weight reduction through satiety. This argument is supported by proven clinical trials and other research studies. While it is typically thought that 5-HT2C receptors assist in regulating appetite, endocrine secretion, and mood, the exact mode of action in appetite regulation is not known.


Receptor EC50 [nM] Ki[nM]
5-HT2C 39 13
5-HT2B 2380 147
5-HT2A 553 92


Use of Lorcaserin HCL powder

If we consider genuine Lorcaserin reviews out there, then this is probably the best weight loss pill on the market today. Certain overweight people, i.e., those who have weight-related medical conditions or those who are obese can significantly benefit from this product.

When used in conjunction with a doctor-approved workout program, low-calorie diet program, and lifestyle change, Lorcaserin can help one do a lot more than just lose weight – it can help lower the many health risks that are associated with obesity, including high blood pressure, diabetes, heart disease, and early death.

According to the Center for Disease Control, losing just 5 to 10 percent of the total body weight can present some health benefits such as improvements in blood sugars, blood cholesterol, and blood pressure.


 The dosage of Lorcaserin HCL powder

Adults are supposed to take two pills per day. You’ll therefore need to take 60 pills per month. According to FDA, one should use the drug during the rest of his/her life to sustain a healthy weight.

It’s important to note that positive results should be seen after 12 weeks. If you won’t have lost at least 5 percent of your baseline body weight by then, you are advised to stop using the pill. Even with continued use, it’s less likely that you’ll achieve and sustain clinically meaningful weight loss.


Lorcaserin HCL Precautions

It is good to remember that your health care professional has prescribed this drug because they have judged that the advantage you get is higher than the risks of the side effects. Most people who take this drug do not show serious side effects.

Before you take lorcaserin, let your pharmacist or doctor know whether you’re allergic to the drug; or whether you have any other allergies. Lorcaserin contain inactive ingredients that can lead to allergic reactions or other issues. Ask your pharmacist to give you more details.

Before take this drug, inform your pharmacist or doctor about your medical history, in particular of kidney problems, diabetes,  liver problem,  heart diseases  (including heart block, heart valve disease, slow heartbeat, heart failure)  problems which may increase the risk of painful/prolonged erections in men (including  deformed penis, Peyronie’s disease, multiple myeloma, sickle cell anemia,  leukemia).

This appetite suppressant pill can make you slow your thinking or dizzy. Marijuana or alcohol may make these effects worse. Do not use machinery, drive, or do anything which demands alertness until you’re able to do it carefully. Limit alcoholic beverages and talk to your doctor if you’re using marijuana.

If you’re to undergo a surgical procedure, it is prudent that you tell your dentist or doctor about all the products you take (including nonprescription drugs, herbal products, and prescription drugs).

If you’re living with diabetes, this weight loss pill may affect your blood sugar. Make sure you check your blood sugar level at regular intervals as advised and share your results with the doctor. Let your doctor know if you have low blood sugar symptoms. Your health care professional may require to adjust your exercise program, diet or diabetes medication.

This drug must not be taken during pregnancy because it may harm the unborn baby. Ask your doctor about the application of the reliable forms of birth control. If you are pregnant or become pregnant, tell your health care professional immediately.

So far, it is unknown whether this drug passes into breast milk. To prevent the possibility of risk to an infant, breastfeeding when using this medication is not recommended. Make sure that you consult your doctor before you breastfeed.

Read the User Information Leaflet carefully if available from your doctor before you start using lorcaserin and any time you get a refill. In case you have any question, ask your pharmacist or doctor.

Take this appetite suppressant pill by mouth with or without a meal as directed by your pharmacist, usually two times per day. Use this drug regularly to get the most out of it. To assist you to remember, take the pill at the same times every day.

Lorcaserin is a habit-forming drug. Do not increase the dose or take this pill more frequently than prescribed. The condition you have may not improve any quicker, and the risk of side effects may increase.

Severe drug interactions can take place when particular drugs are used together with lorcaserin pill. Tell your doctor about all the drugs which you use currently, and any other prescription you begin or stop using.

Lorcaserin weight loss pill is not approved for use by persons younger than 18 years old.


How should I take Lorcaserin HCL powder?

Do not chew, break, or crush an extended-release tablet. Just swallow it whole.

Lorcaserin appetite suppressant is just part of a complete treatment program of which should also include exercise, weight control, diet, and always test your blood sugar. Follow your medication, nutrition, and workout routines very strictly.

Store the medications at room temperature away from heat and moisture.

Keep the record of the amount of drugs used from all the bottles. Lorcaserin weight loss pill is a drug of abuse, and you should always be aware if someone is using your medication without a prescription or improperly.

Never share lorcaserin medicine with anyone else. Keep the drug in a place where no one else can get it.


What happens in case you miss a Lorcaserin dose?

Simply take the missed dose immediately you recall. You should skip the missed dose if the time for the next scheduled dose is almost. Do not take an extra dose to make up for a missed dose.


What happens if you overdose of Lorcaserin?

Look for emergency medical assistance or contact the Poison Help line at 1-800-222-1222.


What should I avoid taking while on lorcaserin?

Do not take any other over-the-counter or prescription weight-loss products without the advice of your doctor. Also, don’t take cold or cough medications when taking lorcaserin pill.


What other medicines may affect lorcaserin?

The following  drugs may affect how lorcaserin works:

  • A “triptan” which are migraine headache medicines–such as Maxalt, Zomig almotriptan, rizatriptan, sumatriptan, frovatriptan,  zolmitriptan, Imitrex,  and others.
  • Cabergoline;
  • linezolid;
  • any kind of antidepressant
  • lithium;
  • John’s wort;
  • erectile dysfunctiondrugs– Levitra, Viagra avanafil, Cialis, sildenafil, tadalafil, and others;
  • tramadol;
  • tryptophan(also known as L-tryptophan);
  • cough or cold drugs which contains dextromethorphan;or
  • medications to treat mental illness, mood or anxiety disorder.

The above list is not exhaustive. Other medicines may affect lorcaserin, and not all possible interactions have been listed in this medication guide.


BBC Reports On Safety and Efficiency of Lorcaserin HCL (CAS 616202-92-7)

There have been several BBC reports on Lorcaserin concerning not only the efficiency but also the safety of the medicine. According to BBC, a recent study, published in a New England Journal of Medicine, indicates people using lorcaserin appetite suppressant pill lost an average of around 8.8lb (4kg) over a record period of as little as three and a half years. The results of this study proved that lorcaserin is undoubtedly one of the best weight loss pills.

The report also says the medicine since it functions by suppressing appetite, do not put users at high risk of heart conditions.The published study followed a whopping 12,000 obese or overweight patients in the USA over 40 months.

After three and a half years, adults taking lorcaserin were three times more likely than not to have reduced five to ten percent of their body mass than those receiving a placebo, according to one of the lead researchers of the study, Dr. Erin Bohula.

Tests conducted on the heart valve didn’t show any significant differences compared to the heart valves of those taking the placebo. Having in mind that this has been the primary concern when it comes to the safety of other slimming pills, lorcaserin could potentially be the best weight loss pill.

Adults taking medicine were also at low risk of type 2 diabetes. The pill costs around £155-225  ($220-290) per month dose in the US. Lorcaserin provides an excellent alternative to invasive weight-reduction procedures like gastric band surgery among others.

Another BBC report featured a study by researchers at the University of Aberdeen’s Rowett Institute who conducted a research on appetite. The scientists said that their research on appetite had led them to a specific part of the brain.

They noticed that by influencing those specific cells with medicines they were able to lower food intake. Since lorcaserin works by this mechanism, the results of this study not only opened doors for new medications like lorcaserin but also reinforced what experts believe about lorcaserin—its safety and efficiency.