I. LY2183240 basic Characters:
|Storage Temp:||-20°C Freezer|
II. LY2183240 in weight loss cycle
LY 2183240;5-[[(1,1′-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE;5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide;LY-2183240 MN-25;1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-;5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide;N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide;LY2183240/LY-2183240
Solubility & Usage Information:
DMSO to 100 mM
ethanol to 50 mM with gentle warming
When purchsed as a 1mg unit, this product is supplied as a lyophilized solid and may be very hard to visualize. Solutions should be made by adding solvent directlyto the vial. The vial should then be vortexed vigorously to ensure the product has completely dissolved.
Stability and Solubility Advice:
Some solutions can be difficult to obtain and can be encouraged by rapid stirring, sonication or gentle warming (in a 45-60°C water bath).
Our standard recommendations are:
SOLIDS: Provided storage is as stated on the product label and the vial is kept tightly sealed, the product can be stored for up to 6 months from date of receipt.
SOLUTIONS: we recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at -20°C or below and used within 1 month. Wherever possible solutions should be made up and used on the same day.
3. Warning on LY2183240
3.1 Harmful if swallowed;wash(hands)throughly after handing;
Effect and Symptoms: Material may be irritating to the mucous membranes and upper respiratory tract;may be harmful by inhalation or skin abosorption;may cause eye,skin,or respiratory system irritation.
3.2 Exposure control/personal protection
Enginnering controls（ventilation etc）：Use process enclosures,local exhaust ventilation;or other engineering controls to control airborne levels below recommended exposure limits
Eye protection: safety glasses
Protective Gloves: Compatible chemical-resistant gloves
Other protective clothing: Lab coat
Respiratory equipment(Specify type): NIOSH approved respirator,as conditions warra
Work/Hygienic/Maintenan: Do not take internally
ce Practices: Facilities storing or utilizing this material should be equipped with an eyewash and a safety shower.Wash thoroughly after handing.
4.1 LY-2183240 is an extremely new chemical to be made available to the research market. We are proud to be one of the suppplier to obtain this chemical. Laboratories have found a new chemical which although different to previous cannabinoids,still may be useful for some types of novel research. LY-2183240 seems to act upon the endocannabinoid anandamine by acting as a potent reuptake inhibitor. Furthermore, LY-2183240 inhibits FAAH or fatty acid amide hydrolase, due to FAAH being the enzyme responsible for the breakdown of anandamine, this allows for more anandamine to be present. A potent inhibitor of anandamide uptake (IC50=7.3nM). Systemic administration to rodents elevates brain anandamide levels and shows efficacy in a rodent model of persistent pain. LY2183240 also inhibits FAAH hydrolytic activity (IC50=12.4nM) as well as other brain serine proteases and represents a new chemotype for the design of new selective FAAH inhibitors. Radiolabeled LY2183240 has been used to identify a high-affinity, saturable anandamide transporter binding site on RBL-2H3 cell membranes distinct from FAAH. LY2183240 is not a canabinoid receptor agonist so its not covered. It works because it increases the amount of natural cannabinoids in the brain. Another compound that may be released is JZL195 it increases both 2-AG and AEA, by preventing the breakdown of these two natural cannabinoids by inhibiting MAGL and FAAH.
4.2 Handing and storage:
Precautions for safe handing: Use in a chemical fume hood,with air supplied by an
independent system.Avoid inhalation,contact with eyes,skin and clothing.Avoid the formation of dust and aerosols. Use in a well-ventilated area. Keep away from sources of ignition. Avoid prolonged or repeated exposure.
Conditions of safe storage, including any imcompatibilities: Store in cool,well-ventilated area. Keep away from direct sunlight. Keep container tightly sealed until ready for use. Recommended storage termperature: Store at +4℃
Specific end uses: Use in a laboratory fume hood where possible.
4.3 Fire-fighting measures：
Extinguishing media(Suitable extinguishing media): Use water spray, alcohol-resistantfoam, dry chemical or carbon dioxide；
Special hazards arising from the substance or mixture: In combustion, may emit toxic fumes；
Precautions for fire-fighters Wear suitable protective clothing to prevent contact withskin and eyes and self-contained breathing apparatus.
4.4 Accidential release measures：
Personal precautions, protective equipment and emergency procedures：do not take action without suitable protective clothing – see section 8 of SDS. Evacuate personnel to safe areas. Ensure adequate ventilation. Avoid breathing vapors, mist, dust or gas；
Environmental precautions: do not let product enter drains；
Methods and materials for containment and cleaning up: Cover spillage with suitable absorbent material；
Using non-spark tools, sweep up material and place in an appropriate container. Decontaminate spill site with 10% caustic solution and ventilate area until after disposal is complete.
Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order(Within 1kg)can be sent out in 3 workingdays after payment.
6. LY2183240 Recipes:
To inquiry our Customer Representitive(CSR) for details, for your reference.
7. LY2183240 Marketing:
To be provided in the coming future.
III. LY2183240 HNMR
IV. How to buy LY2183240 from AASraw?
1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.
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