Megestrol acetate powder

AASraw is with synthesis and production ability from gram to mass order of Megestrol acetate powder (595-33-5), under CGMP regulation and trackable quality control system.

Megestrol acetate(MGA) powder, sold under the brand name Megace among others, is a progestin medication which is used mainly as an appetite stimulant to treat wasting syndromes such as cachexia.It is also used to treat breast cancer and endometrial cancer, and has been used in birth control.MGA is generally formulated alone, although it has been combined with estrogens in birth control formulations. It is usually taken by mouth.

Product Description

 

Megestrol acetate powder video

 

 


 

I.Megestrol acetate powder basic Characters:

 

Name: Megestrol acetate powder
CAS: 595-33-5
Molecular Formula: C19H26O3
Molecular Weight: 302.41
Melt Point: 244-246°C
Storage Temp: Room temperature
Color: White powder

 


 

II. Megestrol acetate cycle

 

1. Names:

Brand Names: Megace, Megace ES
Generic Name: megestrol (Pronunciation: meh JESS trol)

 

2. Megestrol acetate Usage:

MGA is used mainly as an appetite stimulant to promote weight gain in a variety of situations.When given at very high dosages, it can substantially increase appetite in most individuals, even those with advanced cancer, and is often used to boost appetite and induce weight gain in patients with cancer or HIV/AIDS-associated cachexia.In addition to its effects on appetite, MGA appears to have antiemetic effects.MGA is also used as an antineoplastic agent in the treatment of breast cancer and endometrial cancer.It is significantly inferior to aromatase inhibitors in both clinical effectiveness and tolerability as a second-line therapy for breast cancer after tamoxifen failure.MGA was formerly used in combined oral contraceptives in combination with ethinylestradiol or mestranol,and has been used in a combined injectable contraceptive in combination with estradiol as well.

Although it has not been approved for these uses, MGA has been studied and/or used off-label for a variety of indications including menopausal hormone therapy and the treatment of hot flashes,gynecological/menstrual disorders, endometriosis,endometrial hyperplasia,ovarian cancer, prostate cancer,benign prostatic hyperplasia,male breast cancer,and precocious puberty.

Appetite stimulation is achieved with MGA with oral dosages of 400 to 800 mg/day.The optimal dosage with maximum effect for appetite stimulation has been determined to be 800 mg/day.The recommended oral dosage of MGA for breast cancer is 40 mg four times per day (160 mg/day total), while the medication is used at an oral dosage of 40 to 320 mg/day in divided doses for endometrial cancer.It has been used at far lower dosages (e.g., 1–5 mg/day oral, 25 mg/month i.m.) in combination with an estrogen for contraceptive purposes.

 

3.What is the dosage of Megestrol acetate(CAS 595-33-5)?

MGA is available as 5 mg, 20 mg, and 40 mg oral tablets and in oral suspensions of 40 mg/mL, 125 mg/mL, 625 mg/5 mL, and 820 mg/20 mL.It was used at doses of 1 mg, 2 mg, 4 mg, and 5 mg in combined oral contraceptives.MGA has been used at a dose of 25 mg in combination with an estrogen in combined injectable contraceptives.

 

4.How Megestrol acetate works?

MEGACE (megestrol acetate, USP) Oral Suspension contains megestrol acetate, a synthetic derivative of the naturally occurring steroid hormone, progesterone. Megestrol acetate is a white, crystalline solid chemically designated as 17α-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione. Solubility at 37°C in water is 2 μg per mL, solubility in plasma is 24 μg per mL. Its molecular weight is 384.51. The empirical formula is C24H32O4.

 

5.Warning:

Megestrol can harm an unborn baby or cause birth defects. Do not use megestrol if you are pregnant.

Before you take megestrol, tell your doctor if you have diabetes or a history of stroke or blood clot.

Your dosage needs may change if you have surgery, are ill, are under stress, or have an infection. Do not change your medication dose or schedule without your doctor’s advice.

Megace ES contains a higher concentration of megestrol than Megace. Ask your pharmacist if you have any questions about the medicine you receive at the pharmacy.

 

6.Megestrol acetate Raw Powder:

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.

 

7.Megestrol acetate Raw Powder Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

8.Megestrol acetate Marketing:

To be provided in the coming future.

 

9.Does Megestrol acetate Have Any Side Effects?

The most common side effect of MGA is weight gain, with an incidence of 15 to 70% at the high dosages used to treat breast cancer.Other side effects include vaginal bleeding (7–8%), nausea (7%), and edema (5%), as well as others such as dizziness and shortness of breath.MGA can cause hypogonadism and associated symptoms like diminished secondary sexual characteristics, sexual dysfunction, osteoporosis, and reversible infertility in men and premenopausal women.Combining MGA with an androgen/anabolic steroid like oxandrolone, nandrolone decanoate, or testosterone in men can alleviate MGA-associated symptoms of hypoandrogenism as well as further increase appetite and weight gain.Less common but more serious side effects of MGA include cardiovascular/thromboembolic complications such as thrombophlebitis. It may also cause glucocorticoid side effects such as Cushing syndrome-like symptoms, steroid diabetes, and adrenal insufficiency at high dosages.Case reports of deep vein thrombosis, pulmonary embolism, jaundice, intrahepatic cholestasis, and meningiomas in association with high-dosage MGA have been published.

 


 

III. Megestrol acetate powder HNMR

 

We are Aprepitant powder supplie,Aprepitant powder for sale,Raw Aprepitant powder (170729-80-3) hplc≥98% | AASraw R&D Reagents

 


 

IV. How to buy Megestrol acetate powder from AASraw?

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


 

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