MMAD(Demethyldolastatin 10) (203849-91-6) HPLC≥98% | AASraw
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MMAD (Demethyldolastatin 10)

Rating: SKU: 203849-91-6. Category:

AASraw is with synthesis and production ability from gram to mass order of MMAD(Demethyldolastatin 10) (CAS 203849-91-6), under CGMP regulation and trackable quality control system.

Additionally, MMAD is reported to be used in the production of site-specific antibody drug conjugates (NDCs). In the NDCs, MMAD is combined with anti-5T4 antibody or anti-Her2 antibody. It is shown that the NDCs demonstrate better efficacy and pharmacokinetics.

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Product Description


MMAD (Demethyldolastatin 10) video




MMAD (Demethyldolastatin 10) basic Characters


Name: MMAD(Demethyldolastatin 10)
CAS: 203849-91-6
Molecular Formula: C41H66N6O6S
Molecular Weight: 771.06
Melt Point: N/A
Storage Temp: Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Color: White to off-white(solid)



MMAD(Demethyldolastatin 10) (203849-91-6) usage in steroids cycle



Synonyms: Demethyldolastatin 10 (203849-91-6);Monomethylauristatin D;Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide


Warning on MMAD(Demethyldolastatin 10)

Product has not been fully validated for medical applications. For research use only

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.


Further instructions

In Vitro: MMAD(Demethyldolastatin 10) (203849-91-6) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity

In Vivi: The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.



How to buy MMAD ; buy Demethyldolastatin 10 from AASraw


1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
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