MMAD(Demethyldolastatin 10)

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AASraw is with synthesis and production ability from gram to mass order of MMAD(Demethyldolastatin 10) (CAS 203849-91-6), under CGMP regulation and trackable quality control system.

Additionally, MMAD is reported to be used in the production of site-specific antibody drug conjugates (NDCs). In the NDCs, MMAD is combined with anti-5T4 antibody or anti-Her2 antibody. It is shown that the NDCs demonstrate better efficacy and pharmacokinetics.

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Product Description


MMAD(Demethyldolastatin 10) video




I.MMAD(Demethyldolastatin 10) basic Characters:


Name: MMAD(Demethyldolastatin 10)
CAS: 203849-91-6
Molecular Formula: C41H66N6O6S
Molecular Weight: 771.06
Melt Point: N/A
Storage Temp: Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Color: White to off-white(solid)



II. MMAD(Demethyldolastatin 10) (203849-91-6) usage in steroids cycle



Synonyms: Demethyldolastatin 10 (203849-91-6);Monomethylauristatin D;Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide


2.MMAD(Demethyldolastatin 10) Usage:


3.Warning on MMAD(Demethyldolastatin 10)

Product has not been fully validated for medical applications. For research use only

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.


4.Further instructions:

In Vitro: MMAD(Demethyldolastatin 10) (203849-91-6) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity

In Vivi: The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.



III. MMAD(Demethyldolastatin 10) (203849-91-6) HCML

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IV. How to buy MMAD ; buy Demethyldolastatin 10 from AASraw?


1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.



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