MMAD (Demethyldolastatin 10) video
MMAD (Demethyldolastatin 10) basic Characters
|Storage Temp:||Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
|Color:||White to off-white(solid)|
MMAD(Demethyldolastatin 10) (203849-91-6) usage in steroids cycle
Synonyms: Demethyldolastatin 10 (203849-91-6);Monomethylauristatin D;Monomethyl Dolastatin 10
Chemical Name: (S)-N-((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(((S)-2-phenyl-1-(thiazol-2-yl)ethyl)amino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)-N,3-dimethyl-2-((S)-3-methyl-2-(methylamino)butanamido)butanamide
Warning on MMAD(Demethyldolastatin 10)
Product has not been fully validated for medical applications. For research use only
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
In Vitro: MMAD(Demethyldolastatin 10) (203849-91-6) is coupled through a stable oxime-ligation process to yield several near-homogenous antibody-drug conjugates (ADCs) with a drug-to-antibody ratio of ~2.0. The resulting conjugates demonstrate good pharmacokinetic properties, potent in vitro cytotoxic activity against HER2+ cancer cells. When compared with ADCs prepared by cysteine alkylation following native interchain disulfide reduction, site-specific unnatural-amino-acid-based ADCs are shown to have increased in vitro cytotoxicity
In Vivi: The resulting antibody-drug conjugates (ADCs) demonstrate complete tumour regression in rodents. They also have an improved toxicology profile in rats.
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