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MMAF (Hydrochloride) (1415246-68-2)

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AASraw is with synthesis and production ability from gram to mass order of MMAF (Hydrochloride) (CAS 1415246-68-2), under CGMP regulation and trackable quality control system.

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Product Description

 

MMAF (Hydrochloride) video

 

 


 

MMAF (Hydrochloride) basic Characters

 

Name: MMAF (Hydrochloride)
CAS: 1415246-68-2
Molecular Formula: C39H66ClN5O8
Molecular Weight: 768.42
Melt Point: 314.3° C at 760 mmHg (Predicted)
Storage Temp: Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Color: White crystalline powder

 


 

MMAF(Hydrochloride) usage in steroids cycle

 

Names

MMAF (Hydrochloride) (1415246-68-2) is also call Monomethylauristatin F Hydrochloride, MMAF HCL

 

MMAF(Hydrochloride) Usage

Medical scientist do a lot reseach on MMAF, here below is some comments for reference:
In Vitro: MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC50 values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF display pronounced activities. On a molar basis, the cAC10-L1-MMAF4 is an average of over 2200-fold more potent than free MMAF and is active on all the CD30-positive cell lines tested

In Vivo: The maximum tolerated dose in mice of MMAF (1415246-68-2) (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF4 has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF4 ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively

 

Warning on MMAF(Hydrochloride)

For research used only

 

Further instructions

It is recorded that Monomethylauristatin F Hcl(MMAF Hcl) is an antitubulin agent that inhibit cell division by blocking the polymerization of tubulin; and thecytotoxic activity is lower than MMAE; and it is a antibody drug cytotoxin.

Cell Assay
Cells are treated with serial dilutions of test molecules and incubated 4-6 days depending on cell line. Assessment of cellular growth and data reduction to generate IC50 values is done using Alamar Blue dye reduction assay
MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Administration
Mice: study shows that when subcutaneous Karpas 299 tumor size reaches 300 mm3, three animals per group receives one injection of 10 mg antibody component/kg body weight of either cAC10-L1-MMAF4 or cBR96-L1-MMAF (1415246-68-2) 4 intravenously. Tumors are then removed and placed in optimal cutting temperature compound, and 5 μm-thin frozen tissue sections are stained using immunohistochemistry evaluation
MCE has not independently confirmed the accuracy of these methods. They are for reference only.

 


 

How to buy MMAF ; buy Hydrochloride from AASraw

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 

 


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COA

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Recipes

References & product citations

1 review for MMAF (Hydrochloride) (1415246-68-2)

  1. Rated 5 out of 5

    Aasraw

    MMAF (Hydrochloride) powder is genius

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