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Nomegestrol Acetate powder

Rating: SKU: 58652-20-3. Category:

AASraw is with synthesis and production ability from gram to mass order of Nomegestrol acetate powder (58652-20-3), under CGMP regulation and trackable quality control system.

Nomegestrol acetate powder , chemical name 17-Hydroxy-6-metyl-19-norpregna-4,6-diene-3,20-dione, is a potent, highly selective progestogen, a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors.

Product Description


Nomegestrol Acetate powder video




Nomegestrol Acetate powder basic Characters


Name: Nomegestrol Acetate powder
CAS: 58652-20-3
Molecular Formula: C21H28O3
Molecular Weight: 328.45
Melt Point: 177-180℃
Storage Temp: cold storage
Color: White or off white powder



Nomegestrol Acetate powder cycle



Chemical Names: Nomegestrol Acetate powder
Brand Names: Lutenyl and Zoely, and others, 19-Normegestrol powder, Nomegestrol(INN) powder,58652-20-3


Nomegestrol Acetate powder Usage

Nomegestrol Acetate powder(CAS 58652-20-3) is a potent, orally active progestogen with a favourable tolerability profile and neutral metabolic characteristics. Unlike the majority of older progestogens, which were 19-nortestosterone derivatives synthesized primarily for their antigonadotropic activity as a component of hormonal contraception in combination with an estrogen, Nomegestrol Acetate powder is a 19-norprogesterone derivative designed to bind specifically to the progesterone receptor, and is relatively lacking in affinity for other steroid receptors. Nomegestrol Acetate powder exerts strong antiestrogenic effects at the level of the endometrium and has potent antigonadotropic activity, but without any residual androgenic or glucocorticoid properties. At a dosage of 1.25 mg/day, Nomegestrol Acetate powder inhibits ovulation while permitting follicle growth, whereas at dosages of 2.5 or 5 mg/day, both ovulation and follicle development are suppressed. The antigonadotropic action of Nomegestrol Acetate powder is mediated, like other progestins, at the hypothalamic and pituitary level. Moreover, Nomegestrol Acetate powder has partial antiandrogenic activity. Absorption of Nomegestrol Acetate powder is rapid after oral administration, reaching a peak serum concentration within 4 hours, with a terminal half-life of approximately 50 hours..

Nomegestrol Acetate powder(19-Normegestrol powder) has been used successfully for the treatment of some gynaecological disorders (menstrual disturbances, dysmenorrhoea, premenstrual syndrome) and as a component of HRT in combination with estradiol for the relief of menopausal symptoms; it has been approved in Europe as monotherapy for the treatment of the menopausal syndrome, uterine diseases and menorrhagia, and in combination with an estrogen for the treatment of menopausal symptoms. In vitro data suggest that Nomegestrol Acetate powder preserves the beneficial haemostatic effects of estrogen; furthermore, Nomegestrol Acetate powder has a neutral or beneficial effect on lipid profiles, and does not adversely affect glucose metabolism or bodyweight. Nomegestrol Acetate powder has shown a lack of profilerative activity in normal and cancerous breast tissue, and does not have a deleterious effect on bone remodelling. These potent antigonadotropic properties, and other beneficial metabolic and pharmacological characteristics, suggest that Nomegestrol Acetate powder can be an effective progestogen for use in combination with an estrogen in oral estrogen/progestogen contraceptive treatment and in HRT, while it also provides some non-contraceptive benefits for women’s health.


What is the dosage of Nomegestrol Acetate powder


Nomegestrol Acetate powder(NOMAC) is available both alone and in combination with estrogens.The following formulations are available:

NOMAC 3.75 mg and 5 mg oral tablets (Lutenyl) – indicated for menopausal hormone therapy and gynecological disorders

NOMAC 3.75 mg and estradiol 1.5 mg oral tablets (Naemis) – indicated for menopausal hormone therapy

NOMAC 2.5 mg and estradiol 1.5 mg oral tablets (Zoely) – indicated for contraception

The availability of these formulations differs by country

If you have missed a period
If you have taken all of your tablets at the right time, and you have not vomited, or had severe diarrhoea or used other medicines then you are very unlikely to be pregnant. Continue to take Nomegestrol Acetate powder(NOMAC) as usual.
If you miss your period twice in a row, you may be pregnant. Do not start the next pack of Nomegestrol Acetate powder(NOMAC) until your doctor has checked you are not pregnant.

If you take too much (overdose)
There have been no reports of serious harmful effects from taking too many Nomegestrol Acetate powder(NOMAC) at one time. If you take too much Nomegestrol Acetate powder(NOMAC) you may feel sick, vomit or have vaginal bleeding.
If you discover a child has taken Nomegestrol Acetate powder(NOMAC) , ask your doctor for advice


How Nomegestrol Acetate powder works

NOMAC is an oral contraceptive, commonly known as a “Birth Control Pill” or “The Pill” that has been prescribed to prevent you from getting pregnant.
NOMAC prevents pregnancy in several ways:
-It inhibits the egg release by stopping it maturing.
-Changing the cervical mucus consistency making it difficult for the sperm to reach the egg.
-Changing the lining of the uterus making it less suitable for implantation.

Like many other progestogens,NOMAC has been assessed and found in vitro to inhibit the conversion of estrone sulfate to estrone (via inhibition of steroid sulfatase) and estrone to estradiol (via inhibition of 17β-HSD) at high concentrations (0.5–50 μM) and to stimulate the conversion of estrone into estrone sulfate (via activation of estrogen sulfotransferase activity) at low concentrations (0.05–0.5 μM), whilst not affecting aromatase activity at any tested concentration (up to 10 μM).These activities appear to be PR-dependent, as NOMAC is more potent in producing them in PR-rich cell lines (e.g., T47-D vs. MCF-7) and they can be blocked by the PR antagonist mifepristone (RU-486).Although the clinical implications of these actions are unclear and they have yet to be confirmed in vivo or assessed in clinical studies, it has been suggested that NOMAC and certain other progestins may be useful in the treatment of ER-positive breast cancer by decreasing levels of estrogen in breast tissue.In accordance with this notion, in vitro, NOMAC does not have proliferative effects on breast tissue, does not stimulate breast cell proliferation via PGRMC1 (similarly to progesterone), and reduces the breast proliferative effects of estradiol when added to it in medium



Do not take Nomegestrol Acetate powder(NOMAC) if you have an allergy to:
-any medicine containing Nomegestrol Acetate powder or estradiol
-any ingredients listed at the end of this leaflet.

Some of the symptoms of an allergic reaction may include:
-shortness of breath
-wheezing or troubled breathing
-swelling of the face, lips, tongue or other parts of the body
-rash, itching or hives on the skin.


Nomegestrol Acetate powder(CAS 58652-20-3)

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.


Nomegestrol Acetate powder Marketing

To be provided in the coming future.


Does Nomegestrol Acetate powder Have Any Side Effects

Like all medicines, Nomegestrol aceate(NOMAC) can have side effects. Sometimes they are serious, most of the time they are not.

Very common side effects (occurring in more than one per 10 users):
-changes in the menstrual cycle (e.g. absence of menstruation or breakthrough bleeding/spotting)

Common side effects (occurring in more than one per 100 users, but less than one in 10 users):
-decreased interest in sex;
-depression/depressed mood;
-mood changes;
-headache or migraine;
-feeling sick (nausea);
-breast pain;
-pelvic pain;
-weight gain.

Uncommon side effects (occurring in more than one per 1000 users, but -less than one in 100 users):
-increased appetite;
-fluid retention (oedema);
-hot flush;
-swollen abdomen;
-increased sweating;
-hair loss;
-dry skin;
-oily skin;
-sensation of heaviness;
-regular but scanty periods;
-larger breasts;
-breast lump;
-milk production while not pregnant;
-premenstrual syndrome;
-pain during intercourse;
-dryness in the vagina or vulva;
-spasm of the uterus;
-increase in the level of liver enzymes.



How to buy Nomegestrol Acetate powder from AASraw


1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.