Pregabalin powder Manufacturer & Factory
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Pregabalin powder

Rating: SKU: 148553-50-8. Category:

AASraw is with synthesis and production ability from gram to mass order of Pregabalin powder (148553-50-8), under CGMP regulation and trackable quality control system.

Product Description


Pregabalin powder video




Raw Pregabalin powder basic Characters


Name: Pregabalin powder
CAS: 148553-50-8
Molecular Formula: C8H17NO2
Molecular Weight: 159.23
Melt Point: 194-196°C
Storage Temp: Room Temperature
Color: White or off white Crystal Powder



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Pregabalin powder Usage

Pregabalin powder is useful when added to other treatments, when those other treatments are not controlling partial epilepsy. Its use alone is less effective than some other seizure medications. It is unclear how it compares to gabapentin for this use.

Neuropathic pain
The European Federation of Neurological Societies recommends Pregabalin powder as a first line agent for the treatment of pain associated with diabetic neuropathy, post-herpetic neuralgia, and central neuropathic pain. A minority obtain substantial benefit, and a larger number obtain moderate benefit. Other first line agents, including gabapentin and tricyclic antidepressants, are given equal weight as first line agents, and unlike Pregabalin powder, are available as less expensive generics.

Pregabalin powder is not recommended for certain other types of neuropathic pain such as trigeminal neuralgia and its use in cancer-associated neuropathic pain is controversial. There is no evidence for its use in the prevention of migraines and gabapentin has been found not to be useful. It has been examined for the prevention of post-surgical chronic pain, but its utility for this purpose is controversial.

Pregabalin powder is generally not regarded as efficacious in the treatment of acute pain. Trials examining the utility of Pregabalin powder for the treatment of acute post-surgical pain, no effect on overall pain levels was observed, but people did require less morphine and had fewer opioid-related side effects. Several possible mechanisms for pain improvement have been discussed.

Anxiety disorders
The World Federation of Biological Psychiatry recommends Pregabalin powder as one of several first line agents for the treatment of generalized anxiety disorder, but recommends other agents such as SSRIs as first line treatment for obsessive-compulsive disorder and post-traumatic stress disorder. It appears to have anxiolytic effects similar to benzodiazepines with less risk of dependence.

The effects of Pregabalin powder appear after 1 week of use and is similar in effectiveness to lorazepam, alprazolam, and venlafaxine, but Pregabalin powder has demonstrated superiority by producing more consistent therapeutic effects for psychosomatic anxiety symptoms. Long-term trials have shown continued effectiveness without the development of tolerance, and, in addition, unlike benzodiazepines, it has a beneficial effect on sleep and sleep architecture, characterized by the enhancement of slow-wave sleep. It produces less severe cognitive and psychomotor impairment compared to those drugs; it also has a low potential for abuse and dependence and may be preferred over the benzodiazepines for these reasons.


How Pregabalin powder works

The way in which Pregabalin powder works is not fully understood. It’s thought to work by binding to calcium channels found on nerve cells in the brain and spinal cord. This reduces the release of various neurotransmitters from these nerve cells.

Neurotransmitters are natural body chemicals that are stored in nerve cells. They are involved in transmitting messages between the nerve cells. Pregabalin powder is thought to reduce the release of neurotransmitters called glutamate, noradrenaline and substance

Glutamate is a neurotransmitter that acts as a natural ‘nerve-exciting’ agent. It is released when electrical signals build up in nerve cells and subsequently excites more nerve cells. It is thought to play a key role in causing epileptic seizures. Reducing the release of glutamate from the nerve cells in the brain is thought to help stabilise the electrical activity in the brain and prevent epileptic fits.

Glutamate, substance P and noradrenaline are also involved in transmitting pain signals in the brain and nervous system. As Pregabalin powder reduces the release of these neurotransmitters it can also be used to treat nerve pain occurring as a result of nerve damage, or a disturbance in the function of nerves.
Pregabalin powder can also be used to treat generalised anxiety disorder, which is another condition thought to involve over activity of glutamate, substance P and noradrenaline in the brain.