Pyridoxal-5-phosphate Monohydrate

AASraw is with synthesis and production ability from gram to mass order of Pyridoxal-5-phosphate Monohydrate (41468-25-1), under CGMP regulation and trackable quality control system.

Pyridoxal-5-phosphate Monohydrate powder,Vitamin B6 metabolite that acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. Can modify lysyl and valyl residues in proteins. Has the ability to inhibit purinergic receptors and intracellular influx of Ca2+.

Product Description

 

Pyridoxal-5-phosphate Monohydrate video

 

 


 

I.Pyridoxal-5-phosphate Monohydrate basic Characters:

 

Name: Pyridoxal-5-phosphate Monohydrate
CAS: 41468-25-1
Molecular Formula: C8H12NO7P
Molecular Weight: 265.16
Melt Point: 2-8°C
Storage Temp: Room Temperature
Color: Pale Yellow Crystalline

 


 

II. Pyridoxal-5-phosphate Monohydrate cycle

 

1. Names:
Chemical Names: Pyridoxal- 5′-phosphate monohydrate, 3-Hydroxy-2-methyl-5-([phosphonooxy]methyl)-4-pyridinecarboxaldehyde
Codecarboxylase
Other Names: Vitamin B6, Pyridoxal Phosphate, PLP

 

2. Pyridoxal-5-phosphate Monohydrate Usage:

Vitamin B6 metabolite that acts as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase. Also serves as a coenzyme in some decarboxylation and deamination reactions. Can modify lysyl and valyl residues in proteins. Has the ability to inhibit purinergic receptors and intracellular influx of Ca2+.

 

3.What is the dosage of Pyridoxal-5-phosphate Monohydrate?

PLP is useful for modifying lysyl and valyl residues and functions as a coenzyme in transamination reactions by forming a Schiff-base linkage with lysine groups on aminotransferase
PLP is an active form of vitamin B6
Also serves as a coenzyme in some decarboxylation and deamination reactions

 

4.How Pyridoxal-5-phosphate Monohydrate works?

Pyridoxal phosphate (PLP, pyridoxal 5′-phosphate, P5P), the active form of vitamin B6, is a coenzyme in a variety of enzymatic reactions. The Enzyme commission has catalogued more than 140 PLP-dependent activities, corresponding to ~4% of all classified activities. The versatility of PLP arises from its ability to covalently bind the substrate, and then to act as an electrophilic catalyst, thereby stabilizing different types of carbanionic reaction intermediates.

PLP acts as a coenzyme in all transamination reactions, and in certain decarboxylation, deamination, and racemization reactions of amino acids. The aldehyde group of PLP forms a Schiff-base linkage (internal aldimine) with the ε-amino group of a specific lysine group of the aminotransferase enzyme. The α-amino group of the amino acid substrate displaces the ε-amino group of the active-site lysine residue in a process known as transaldimination. The resulting external aldimine can lose a proton, carbon dioxide, or an amino acid sidechain to become a quinoid intermediate, which in turn can act as a nucleophile in several reaction pathways.

In transamination, after deprotonation the quinoid intermediate accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the complex. In addition, PLP is used by aminotransferases (or transaminases) that act upon unusual sugars such as perosamine and desosamine. In these reactions, the PLP reacts with glutamate, which transfers its alpha-amino group to PLP to make pyridoxamine phosphate (PMP). PMP then transfers its nitrogen to the sugar, making an amino sugar.

PLP is also involved in various beta-elimination reactions such as the reactions carried out by serine dehydratase and GDP-4-keto-6-deoxymannose-3-dehydratase (ColD).

It is also active in the condensation reaction in heme synthesis. PLP plays a role in the conversion of levodopa into dopamine, facilitates the conversion of the excitatory neurotransmitter glutamate to the inhibitory neurotransmitter GABA, and allows SAM to be decarboxylated to form propylamine, which is a precursor to polyamines.

 

5.Warning:

This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
from MeSH
Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.
Pharmacology from NCIt
This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine). — Pubchem; Pyridoxal-phosphate (PLP, pyridoxal-5′-phosphate) is a cofactor of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine.

6.Pyridoxal-5-phosphate Monohydrate Raw:

Min order 10grams.
The inquiry on normal quantity(Within 1kg) can be sent out in 12 hours after payment.
For larger order can be sent out in 3 working days after payment.

 

7.Pyridoxal-5-phosphate Monohydrate Raw Recipes:

To inquiry our Customer Representitive(CSR) for details, for your reference.

 

8.Pyridoxal-5-phosphate Monohydrate Marketing:

To be provided in the coming future.

 

9.Does Pyridoxal-5-phosphate Monohydrate Have Any Side Effects?

Pyridoxal Phosphate is the active form of vitamin B6 and a coenzyme for many pyridoxal phosphate (PLP)-dependent enzymes. PLP is involved in numerous enzymatic transamination, decarboxylation and deamination reactions; it is necessary for the synthesis of amino acids and amino acid metabolites, and for the synthesis and/or catabolism of certain neurotransmitters, including the conversion of glutamate into gamma-aminobutyric acid (GABA) and levodopa into dopamine. PLP can be used as a dietary supplement in cases of vitamin B6 deficiency. Reduced levels of PLP in the brain can cause neurological dysfunction.

 


 

III. Pyridoxal-5-phosphate Monohydrate HNMR

 

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IV. How to buy Pyridoxal-5-phosphate Monohydrate from AASraw?

 

1.To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
2.To provide us your inquired quantity and address.
3.Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
4.Payment done and the goods will be sent out in 12 hours(For order within 10kg).
5.Goods received and give comments.

 


 

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