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The history of Tadalafil and its medical uses

Tadalafil was initially developed as an ED therapy by the pharmaceutical corporation Eli Lilly and company.It was later discovered,however,to be useful in treating additional disorders such as PAH and BPH.Tadalafil was approved by the FDA for the treatment of ED in 2003,followed by PAH in 2009 and BPH in 2011.

Since its approval for the treatment of ED,tadalafil has become a popular medication for men with this condition.Because of its prolonged duration of action,which can last up to 36 hours,it is frequently favored over other ED drugs.This allows for more spontaneity in sexual action and less medication forethought.

Tadalafil has been researched for its possible benefits in fields other than medicine.Some studies,for example,have suggested that tadalafil may improve exercise capacity in persons with heart failure.More research,however,is required to fully appreciate the possible benefits of tadalafil in this scenario.

What is tadalafil?

Tadalafil,a phosphodiesterase-5 inhibitor used to treat male sexual diseases such as erectile dysfunction (ED),is marketed as Cialis.

It inhibits the PDE-5 enzyme in the corpora cavernosa of the penis,raises Nitric Oxide levels,and promotes vasodilation,all of which promote blood flow and penile erection.

How does tadalafil work?

It may surprise you that tadalafil was originally explored for the treatment of hypertension.The way it operates in penile blood vessels and tissues was mostly incidental.

The enzyme phosphodiesterase-5 was discovered in smooth muscle cell walls of blood arteries by researchers.When this enzyme is present,cGMP degrades rapidly.While cGMP may be meaningless to you,it promotes blood vessel relaxation and dilatation when activated by proteins.

Tadalafil uses – What is tadalafil use for?

Tadalafil is used to treat erectile dysfunction,benign prostatic hyperplasia,and pulmonary arterial hypertension.Tadalafil (as Cialis) is approved in the United States to treat erectile dysfunction and the signs and symptoms of benign prostatic hyperplasia,and (as Adcirca) to treat pulmonary arterial hypertension and improve exercise performance.

Tadalafil for erectile dysfunction (ED)

Tadalafil is often used to treat ED,a condition in which a man has trouble obtaining or maintaining a satisfactory erection for sexual activity.When sexually stimulated,it helps relax the blood vessels of the penis,increasing blood flow to this area and aiding erections.Tadalafil is recognized for its prolonged activity,which can last up to 36 hours,earning it the moniker “the weekend pill.”

Tadalafil for Benign prostatic hypertrophy(BPH)

The FDA has approved Tadalafil for the treatment of BPH.An enlarged prostate causes BPH.Men with BPH typically have difficulties urinating,a reduced flow of urination,hesitation at the start of urination,and the need to wake up in the middle of the night to urinate.

Many BPH patients have serious underlying sexual function issues.Cialis (Tadalafil) participation in BPH therapy not only improves sexual function,but also has a good influence on urinary issues,increasing treatment effectiveness and patient quality of life.The studies completed confirm the effectiveness of Tadalafil in the treatment of BPH patients.A daily dose of 5 mg Tadalafil without a prescription will help you kill two birds with one stone: erection and urine difficulties.

Tadalafil for Pulmonary arterial hypertension (PAH)

Tadalafil,marketed under the brand name Adcirca,is also FDA-approved to treat pulmonary arterial hypertension (PAH),a kind of high blood pressure that affects the arteries in the lungs.The normal PAH dose is two 20-milligram pills (40 mg) administered twice daily.Tadalafil relaxes the blood arteries in the lungs,lowering the burden on the heart and enhancing exercise capacity and general quality of life in people with PAH.

Tadalafil benefits

Studies have shown that Tadalafil to a greater extent increases the confidence of patients in their ability to have sexual intercourse,the spontaneity of sexual life,and also reduces the degree of anxiety about the time that has passed since taking the drug.At the same time,two-thirds of patients noted the possibility of achieving an erection after a considerable time after taking it,which is preferable for elderly patients,as the main advantage of Tadalafil,which made them choose this particular drug.This fact created in patients a feeling of naturalness in sexual life.

In another aspect,with demand creased,the generic tadalafil already came out.Generic tadalafil cost less than Cialis,and their active ingredient tadalafil powder even cost lesser.Tadalafil benefits those people who don’t have much money and want to get treatment.And people can easily buy tadalafil powder online.What they need to do is to make sure they buy high purity tadalafil powder.

Tadalafil vs sildenafil (viagra),which one is better?

Tadalafil and Sildenagil are both prescription medications used to treat erectile dysfunction (ED).But Tadalafil is also approved to treat enlarged prostate.

Sildenafil was introduced in 1998 and tadalafil was introduced in 2003.Both are active ingredients known as phosphodiesterase type 5 (PDE5) inhibitors and both work in a broadly similar way; by improving blood flow to the penis to help achieve an erection and helping to maintain the erection by keeping the blood there.

Sildenafil often has a faster start of effect than tadalafil.Sildenafil is well-known for its quick onset of action,typically taking effect within 30 to 60 minutes of consumption.Because of its rapid onset,it is appropriate for situations in which you wish to be sexually active soon after taking the prescription.

Tadalafil,on the other hand,typically takes longer to begin working.It usually starts working within 30 minutes to an hour of consumption.

However,tadalafil has an advantage over Sildenafil in that it lasts for a lot longer – 36 hours,compared with 4-5 hours for Viagra. This extended duration is often favored by individuals who prefer spontaneity and want to avoid the need for precise timing.While the longer lasting effectiveness of tadalafil may be a bonus to some,it also means that any side effects will last longer as well.For some men who are more sensitive to these types of medications,sildenafil’s shorter acting timeframe may be more ideal.

Additionally,Sildenafil may last fewer hours if taken on a full stomach,while tadalafil is less influenced by diet.Tadalafil can be taken either with food or on an empty stomach.

Sildenafil is the generic version of the original erectile dysfunction drug Viagra and Tadalafil is the generic version of Cialis.With generic prices as low as they are,most patients can safely and easily buy both sildenafil powder and tadalafil powder online to see which works best for them.Of course,if you experience any side effects with either drug,stop and switch to the other medication such as vardenafil and avanafil.

Tadalafil vs Cialis,which one is better?

From a medical perspective,both Cialis and Tadalafil work in the same way,they have same effects ans side effects.Tadalafil is the active drug in both medications.The contrast all comes down to branding,marketing,distribution and cost.Cialis is the branded name of Tadalafil.Cialis contains the active ingredient tadalafil powder.Cialis is available only by prescription.It’s not available over the counter.But you can buy Tadalafil powder anywhere online.The are many tadalafil powder for sale online.The only thing you need to pay attention to is find the real and reputable tadalafil powder manufacturer.How to ensure you buy real tadalafil powder,ensuring they send you the test reports such as COA,HPLC and HNMR.

Brand-name medications usually cost more than generics.Active ingredient Tadalafil powder tend to cost less than brand-name drugs Cialis.AASraw is a regular manufacturer to produce high quality Tadalafil raw powder.If you purchase tadalafil powder wholesale will get a better price.

Why do bodybuilders use tadalafil?

Steroids is extremely polupar in bodybuilding.Bodybuilder or athelets tend to use anabolic steroids because they can quickly build muscle mass,decrease body fat,and improve athletic performance.Even steroids is popular,they will cause some certain side effects.

Anabolic steroids can disrupt the body’s natural hormone balance,leading to hormonal imbalances.This can result in side effects such as Suppression of Natural Testosterone Production,decreased sperm production and decrease in testicle size.

Testosterone decrease is one of the common side effects of steroid use.Steroids can also weaken a man’s sex drive and cause the testiclesto shrink as the body no longer relies on its own production of testosterone.In another word,Erectile dysfunction (ED).

Tadalafil is a well known medication designed to assist men with erectile difficulties and benign prostatic hyperplasia (BPH).It is most well known as a treatment for ED where Tadalafil promotes increased blood flow to the penis.

This increase in blood flow raised the interest of bodybuilders: if Tadalafil is so great at increase blood flow,could it benefit the muscle as well? This is where the idea of Tadalafil for bodybuilding was born.

Studies have found that tadalafil can increase testosterone levels in the body by influencing the activity of certain enzymes in the body that regulate testosterone production.It has been shown to increase the release of luteinizing hormone (LH),which helps to get Leydig cells to make more testosterone.This suggests tadalafil could potentially be an effective way for bodybuilders and athletes to naturally boost their testosterone levels for better performance.

However,it’s important to note that some users have reported no effect on testosterone levels following a course of tadalafil use.It tell us how is important to get the high purity tadalafil powder from the reputable supplier like AASraw.If you buy tadalafil bulk from AASraw will get a good price.

Tadalafil dosage guide

AASraw as a tadalafil powder supplier.We only good at producing high quality Tadalafil powder.The Tadalafil powder dosage and administration information provided here is for informational purposes only and should not be considered as medical advice.There are four different tadalafil dose strengths in the markets,they are 2.5 milligrams (mg),5 mg,10 mg,and 20 mg.The typical Tadalafil dosage for adults depends on why you are taking it.And no matter what you are treating,you can take your dose with or without food.

Tadalafil can be administered in a variety of ways to treat ED.One method is to take a dosage as needed before sex.In this situation,the work could take up to two hours.The other option is to take lower-dose Tadalafil every day,whether you want to have sex or not.

Tadalafil dosage for erectile dysfunction (as-needed dosage)

Tadalafil dosage for ED is typically 5 mg to 20 mg by mouth,taken at least 30 minutes before sex.Typically,you will begin with a 10 mg dose,which your healthcare professional may adjust up or down based on your response.The effects of tadalafil might extend up to 36 hours.As a result,taking more than one dose per day is not advised.

Tadalafil dosage for erectile dysfunction (tadalafil daily dosage)

Another alternative for treating ED is to take Tadalafil on a daily basis.Tadalafil dose ranges from 2.5 mg to 5 mg per day,administered orally once a day.Most people begin with a 2.5 mg dose,which can be increased to 5 mg depending on how well it works for them.When taking a daily dose,make sure to take it at the same time every day.

Tadalafil dosage for Benign prostatic hyperplasia(BPH)

The standard Tadalafil dose for treating BPH symptoms is 5 mg by mouth once day.You’ll take the same dose if you’re treating both BPH and ED.Remember to take your Tadalafil dose every day at the same time.

Tadalafil dosage for pulmonary arterial hypertension(PAH)

The Tadalafil dosage for PAH is typically higher,starting at 40 mg once daily.People with pulmonary hypertension,then,will receive prescriptions for 20 mg tadalafil tablets specifically indicated for pulmonary hypertension.Take both tablets at the same time each day.Do not divide the 40 mg dose.Your doctor may adjust your dose as needed.

Tadalafil dose for bodybuilding

The suggested tadalafil dose for bodybuilding varies according to the individual’s needs and goals,as well as their age,gender,and health status.Most athletes,however,take 10-20 mg per day in divided doses either once or twice daily.Tadalafil’s effects might last up to 36 hours,so it’s crucial to plan ahead of time while taking this prescription.

It is vital to highlight that tadalafil should not be taken by anyone who has underlying health difficulties such as heart disease or hypertension,as this drug may worsen these illnesses.Furthermore,using tadalafil while pregnant or breastfeeding is not recommended due to the potential negative effects on unborn babies or young children.

Is there anything else to know before taking tadalafil?

It’s always best to read the Patient Information Leaflet (PIL) that comes with your tadalafil tablets before taking them.If you take tadalafil powder,then please make sure to buy the highest quality tadalafil raw powder to avoid unnecessary side effects.

Tadalafil can be dangerous if you have certain medical conditions.You should not take tadalafil if you have any of the following conditions:

• A severe heart or liver problem.
• Recently had a stroke or a heart attack,or if you have low blood pressure.
• Certain rare inherited eye diseases (such as retinitis pigmentosa).
• Ever had loss of vision due to non-arteritic anterior ischaemic optic neuropathy (NAION).

If you have (or have ever had) any of these conditions,tadalafil and other PDE5 inhibitors are unlikely to be suitable for you.If this is the case,you may have to explore other erectile dysfunction treatment options such as penis pumps or topical creams.

This is not an exhaustive list of conditions that make taking tadalafil dangerous.It is strongly advised that you visit a clinician before taking tadalafil to determine whether they are safe for you to consume.

Safety concerns for Tadalafil

As we are not doctor,we are a tadalafil powder supplier only,so we are not professional enough to tell you how to take Tadalafil tablets.Tips are listed here just some general information to take tadalafil.

Unlike some other PDE5 inhibitors,Cialis may be taken with or without food.It’s unlikely to have any impact on its effectiveness or side effects.Here are some conditions need to pay attention to:

Avoid grapefruit juice

Grapefruit and grapefruit juice can enhance levels of Tadalafil in the bloodstream,potentially increasing negative side effects.

Avoid heavy alcohol drinking

Moderate alcohol consumption should have little effect on Tadalafil’s effectiveness.However,even with an ED prescription,substantial alcohol consumption might make achieving an erection difficult.

Know your other medications

Tadalafil may interact with certain medications.In particular,you should not take Tadalafil if you’re also taking nitrates,which are medications that widen arteries to allow greater blood flow.

Nitrates are typically prescribed to treat angina (chest pain brought on by narrowed coronary arteries) or heart failure.

When taken with nitrates or antihypertensive medications called alpha-blockers,Tadalafil could cause a dangerous drop in blood pressure.

Tadalafil may lead to similar problems when used in combination with other antihypertensive drugs.

Other classes of drugs that may interfere with Tadalafil include:

• antiseizure medications
• certain antibiotics
• HIV medications
• oral antifungal medications

You should also avoid taking two PDE5 inhibitors in 1 day,as this can lead to a dangerous drop in blood pressure and other serious side effects.

15.Tadalafil Side effects

Like other prescription drugs,Cialis can cause side effects.Most Cialis side effects are minimal,however PDE5 inhibitors can occasionally induce a variety of more severe negative effects in certain situations.Tadalafil powder is the active ingredient of Cialis.So they work in exactly the same way,both medications can cause the same side effects and drug interactions.Cialis has several common side effects,many of which also occur with other drugs used to treat erectile dysfunction like sildenafil (generic Viagra),vardenafil (Levitra®) or avanafil (Stendra®).These side effects include:

• Headaches
• Heartburn/Indigestion
• Back pain
• Muscle aches
• Facial flushing
• Nasal congestion
• Nasopharyngitis (Common Cold Symptoms)
• Dizziness
• Visual disturbances
• Reduced blood pressure
• Pain in limbs

This is not a complete list of side effects and others may occur.The above side effects may get better over time as your body gets used to the medication.Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time

Where can I buy tadalafil powder online?

Tadalafil is an increasingly popular supplement among People and bodybuilders who are looking for healthy sex life.For those looking for where to buy tadalafil powder online for daily needs, it is very vital to find the real supplier.You need to throw your efforts to find the reliable tadalafil powder supplier.Before buying,please ensure they provide you the test report such as COA,HPLC and HNMR report to guarantee the purity.AASraw provides high quality tadalafil powder which you don’t want to missed.

How to store tadalafil

Keep all medicines out of the reach and sight of children.Store in a cool,dry place,away from direct heat and light.If you buy Tadalafil powder,please store it as direct by its supplier.

FAQ

How quickly does Cialis work?

Cialis begins to act immediately.After around 30 minutes,you may begin to feel its effects.However,it can take up to 2 hours for its full benefits to take action.

What are the risks of mixing tadalafil and alcohol?

As is typically the case,drinking in moderation is usually not an issue; having a couple of beers while taking tadalafil should be safe.Excessive tadalafil (or Cialis 20mg) and alcohol use,on the other hand,can result in major health issues.

Tadalafil and alcohol do not interact directly,but because both are vasodilators,excessive drinking can increase the drug’s negative effects.

Is generic Cialis or tadalafil as effective as Cialis?

Cialis and tadalafil work equally well.The FDA aims to guarantee that generic copies of all brand-name pharmaceuticals have the same clinical advantages as the brand-name counterparts.

The primary distinction between Cialis and tadalafil is price.

Cialis normally costs roughly $365 for 30 tablets,yet prices vary greatly based on the company and drugstore where you get the medication.The generic equivalents are approximately $100 for 30 tablets.

How long does tadalafil (Cialis) take to work?

If you take tadalafil (Cialis) for ED,you should take it 30 minutes before sexual activity.However,it may take 1-2 hours for the full benefits of this drug to take effect.If the as-needed dosing isn’t working for you,talk to your doctor about taking a lower dose of tadalafil (Cialis) daily instead.Because you don’t have to time the dose before sexual activity,using tadalafil (Cialis) on a regular basis may allow for more spontaneity.If you start using tadalafil (Cialis) for BPH,you should notice an improvement in your symptoms within 1 to 2 weeks.

How long does tadalafil (Cialis) last?

Tadalafil (Cialis) can be effective for up to 36 hours following administration.However,this does not guarantee that the erection will last the entire time.It simply means that you may be able to achieve more than one erection throughout this time period without needing to take another dose of tadalafil (Cialis).However,if an erection lasts more than 4 hours,seek emergency medical attention since this might result in lasting penile injury.

Why can’t I stay hard with Cialis?

Using them incorrectly — having the wrong dosage or not following instructions — can cause Cialis not to work.Cialis might also fail if your ED is related to psychological issues — performance anxiety,intimacy issues,low self-confidence and depression can all affect your erections.

How much tadalafil (Cialis) can I take in a day?

Take tadalafil (Cialis) exactly as directed by your doctor.If you take tadalafil (Cialis) as needed for ED,you should only take one pill each day.Tadalafil (Cialis) effects should remain for up to 36 hours following a dose.Taking this drug on a regular basis may increase your chance of major side effects such as priapism or eyesight abnormalities.Consult your healthcare professional if you have any questions regarding your tadalafil (Cialis) dosage.

Does tadalafil keep you hard after coming?

If you’re taking it for erectile dysfunction,you should be able to get an erection between 30 minutes to 36 hours of taking it.For it to work,you must be sexually excited.After you’ve had sex,your erection should go away.

Can I take tadalafil daily?

Tadalafil (Cialis) is a well-known erectile dysfunction (ED) medication.What is its main allure? The medicine is available in low-dose forms that can be taken on a regular basis.This means you can have sex whenever you want,rather than having to take a medication as needed as with other ED brands.

How to take tadalafil for best results?

Take tadalafil at least 30 minutes before having sex if you have erectile dysfunction.If you’re taking tadalafil for prostate enlargement,you can take it in the morning or evening,but it’s better if you do it at the same time every day.

How long can the average man stay erect?

An typical erection might last anywhere from a few minutes to about half an hour.However,given to the numerous factors that might influence erection duration,this can vary greatly.It is also important to note that orgasm does not require an erection.

Is it normal for tadalafil to not work sometimes?

If tadalafil does not work for you,it could be because you did not wait long enough after taking it before engaging in sexual activity.You’ve waited much too long to have sex after taking it.The dose is insufficient.

Does tadalafil work every time?

Tadalafil is an effective erectile dysfunction medication.If tadalafil does not work for you,it could be because you did not wait long enough after taking it before having sex.You waited far too long after taking it to have sex.

Is tadalafil as good as Cialis?

Tadalafil is available in its generic form,or in its branded form,Cialis.The generic form acts in the same way as Cialis,but usually costs a lot less.Likewise,Viagra is the branded form of Tadalafil.

Does Cialis make you harder than Viagra?

Which is more potent,Cialis or Viagra? Contrary to popular misconception,neither Cialis nor Viagra has the ability to make you harder than the other.Each ED medication is helpful in assisting men in achieving and maintaining an erection during sex.

Can I take tadalafil if I don’t have erectile dysfunction?

It’s safe to assume that the pill has provided millions of men with an easy and effective way to improve their sex lives.However,taking Viagra or other erectile dysfunction medications such as Cialis (tadalafil) or Levitra (vardenafil) when you don’t have erectile dysfunction might be harmful.

Who can and cannot take tadalafil

Most men aged 18 and over can take tadalafil for erectile dysfunction.

Most adults aged 18 and over can take it for pulmonary hypertension.

Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine

Scientific Journal paper Author:
1. Emanuel Fryk
Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, SU Sahlgrenska, 413 45 Gothenburg, Sweden
2. Dorota Rogacka
Department of Molecular Biotechnology, Faculty of Chemistry, University of Gdansk, Wita Stwosza 63, Gdansk 80-308, Poland
3. E. Deconinck
Scientific Direction Chemical and Physical Health Risks, Service of Medicines and Health Products, Sciensano, J. Wytsmanstraat 14, B-1050, Brussels, Belgium
4. Iman Shamohammadi
Department of Urology, Nemazee Hospital, Shiraz University of Medical Science, Shiraz, Iran
5. Natsumi Tomita
Department of Hospital Pharmacy, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe do-ri, Mizuho-ku, Nagoya 467-8603, Japan
In no way do these doctors or scientists endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with these physicians. The purpose of citing them is to acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.

Reference

[1] Mónica FZ, De Nucci G. “Tadalafil for the treatment of benign prostatic hyperplasia.”Expert Opin Pharmacother. 2019 Jun;20(8):929-937. doi: 10.1080/14656566.2019.1589452. Epub 2019 Mar 22. PMID: 30901259

[2] Sebastianelli A, Spatafora P, Morselli S, Vignozzi L, Serni S, McVary KT, Kaplan S, Gravas S, Chapple C, Gacci M. “Tadalafil Alone or in Combination with Tamsulosin for the Management for LUTS/BPH and ED.”Curr Urol Rep. 2020 Oct 27;21(12):56. doi: 10.1007/s11934-020-01009-7. PMID: 33108544

[3] Ruopp NF, Cockrill BA. “Diagnosis and Treatment of Pulmonary Arterial Hypertension: A Review.”JAMA. 2022 Apr 12;327(14):1379-1391. doi: 10.1001/jama.2022.4402. PMID: 35412560

[4] Sitbon O, Cottin V, Canuet M, Clerson P, Gressin V, Perchenet L, Bertoletti L, Bouvaist H, Picard F, Prévot G, Bergot E, Simonneau G. “Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension.”Eur Respir J. 2020 Sep 3;56(3):2000673. doi: 10.1183/13993003.00673-2020. Print 2020 Sep. PMID: 32350101

[5] Prasetyo DT, Raharja PAR, Mantiri BJ, Ringoringo DRL, Rahman IA, Felizio J, Tambunan MP, Fadhly SF, Rahardjo HE. “Tadalafil Once a Day for Men with Erectile Dysfunction: Is It Superior than On-Demand Administration?”Acta Med Indones. 2019 Jul;51(3):275-281. PMID: 31699953

[6] Banjac NM, Vasović VM, Stilinović NP, Prodanović DV, Tomas Petrović AD, Vasović LV, Jakovljević VL. “Tadalafil in Increasing Doses: The Influence on Coronary Blood Flow and Oxidative Stress in Isolated Rat Hearts.”Pharmacology. 2022;107(3-4):150-159. doi: 10.1159/000520498. Epub 2021 Dec 10. PMID: 34903698

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