Product Description
What is TB-500?
TB500, also known as Thymosin Beta-4, is a synthetic peptide that is derived from a naturally occurring protein called thymosin beta-4. It consists of a sequence of amino acids and has been the subject of research and speculation regarding its potential therapeutic applications.
Thymosin beta-4 is naturally produced in the human body and plays a role in various physiological processes, including wound healing, tissue repair, and regulation of inflammation. It has been found in high concentrations in blood platelets, where it is released in response to tissue injury.
TB500, the synthetic version of thymosin beta-4, is often used in experimental settings and has gained popularity in the athletic and bodybuilding communities due to its purported ability to enhance recovery and promote healing. Some claims suggest that TB500 can help accelerate tissue repair, increase muscle growth, improve flexibility, and reduce inflammation.
TB 500 background information
As stated previously, TB-500 is a synthetic version of Thymosin Beta 4, a protein peptide that occurs naturally in the bodies of both animals and humans. Although TB-500 is available for research purposes, it is commonly used by many veterinarians who conduct clinical trials using TB-500 on horses.
Thymosin research in horses began in the 1960s.Dr.Allan Goldstein created thymosin alpha 1 to boost immune cell activity and thymosin beta 4 or TB-500 to speed up healing and wound repair.
ln the early, the synthetic version TB-500 was rumored to be rampantly used in competitive horse racing. In horse racing, the use of TB 500 has significantly reduced inflammation and inhibited or reduced adhesion formation following damage — giving horses receiving a significant competitive edge against other horses. It was at this time that testing measures to detect TB-500 in racehorses began to be developed in earnest.
TB-500, Thymosin beta-4, and all other derivatives thereof are now banned from competitive horseracing, as well as all sporting competitions subject to the Code of the World Anti-Doping Agency(WADA).
Thymosin was first used on humans in 1974 when a little girl with a non-functioning thymus gland received an injection of the substance. Since then, more and more athletes and biohackers have started using thymosin for the exact same purposes—repair, inflammation reduction, and hastened recovery.
How does TB-500 (Thymosin Beta-4) work?
The exact mechanism of action of TB500 (Thymosin Beta-4) is not fully understood, and research to establish its precise effects on the body is continuing. However, based on existing information, here are some possible applications for TB500:
Promotion of cell migration
TB500 is thought to improve cell migration, which is the process by which cells migrate to the site of injury or damage. It may help attract cells involved in tissue repair and regeneration to the afflicted location, such as stem cells, fibroblasts, and endothelial cells, facilitating healing and tissue regeneration.
Modulation of inflammation
By modulating the generation and activity of inflammatory molecules, TB500 may have anti-inflammatory effects.TB500 has been shown to reduce the release of pro-inflammatory cytokines, which are chemicals that have a role in the inflammatory response.TB500 may help establish a more conducive environment for healing and tissue repair by lowering inflammation.
Stimulation of angiogenesis
Angiogenesis is the formation of new blood vessels.TB500 has been demonstrated to enhance angiogenesis, potentially by stimulating endothelial cell proliferation and migration, which is important for blood vessel creation. Blood vessel formation can enhance blood flow to wounded areas, giving nutrients and oxygen required for tissue regeneration.
Collagen production
Collagen is a protein that gives tissues structural support.TB500 has been proposed to increase collagen formation, which can aid in tissue regeneration and wound healing.TB500 may help strengthen and mend damaged tissues by boosting collagen synthesis.
TB-500 benefits
TB-500 is a synthetic version of a naturally occurring peptide present in the human body. It has gained popularity in the athletic and bodybuilding communities for its potential benefits. While it’s important to note that research on TB-500 is still ongoing, here are some potential benefits that have been suggested:
Tissue repair and regeneration
TB-500 has been suggested to stimulate tissue repair and regeneration. It may promote the growth of new blood vessels (angiogenesis) and encourage the formation of new tissue, including muscles, tendons, ligaments, and skin. This can be particularly useful for individuals recovering from injuries, as it may speed up the healing process and improve overall tissue health.
Accelerated healing of injuries
TB-500 may help expedite the healing of various types of injuries, such as muscle strains, sprains, and ligament tears. It has been reported to reduce the recovery time needed after an injury by promoting cellular migration and proliferation at the site of injury. This can lead to faster healing and a quicker return to physical activity.
Reduction of Inflammation
TB-500 exhibits anti-inflammatory properties, which can help mitigate inflammation in the body. It may inhibit the production of pro-inflammatory molecules and promote the release of anti-inflammatory substances, thus reducing inflammation and associated pain. This can be beneficial for individuals with chronic inflammatory conditions like arthritis, tendonitis, or bursitis.
Joint and connective tissue health
By supporting tissue repair and reducing inflammation, TB-500 may help improve joint and connective tissue health. It can enhance the integrity and elasticity of tendons, ligaments, and cartilage, leading to improved joint function, increased flexibility, and reduced risk of injuries.
Enhanced muscle growth and recovery
While TB-500 itself is not a direct muscle-building compound, it may indirectly contribute to muscle growth and recovery. By promoting tissue repair and reducing inflammation, it can support the recovery process after intense exercise or injury. This can result in faster muscle repair and growth, improved muscle endurance, and reduced muscle soreness.
Improved hair growth
There is some anecdotal evidence suggesting that TB-500 may have positive effects on hair growth. It is believed to promote blood vessel growth and nutrient delivery to hair follicles, potentially stimulating hair growth and thickness. However, further research is needed to establish this benefit more conclusively.
Cardiovascular Health
TB-500 has been studied for its potential benefits in cardiovascular health. It may promote the growth of new blood vessels, improve blood flow, and enhance heart function. These effects can be beneficial for individuals with cardiovascular conditions, such as heart disease or peripheral artery disease.
What forms of TB-500 are available?
Peptide raw powder form
TB500 raw powder is the raw material to produce lyophilized powder TB500 in vials. It is not ready for individuals to use. Only for research.
Reconstitution
TB-500 (Thymosin Beta-4) is available in the form of a lyophilized powder for reconstitution. This lyophilized powder is typically provided in vials or vial kits. The lyophilized powder is then mixed with a suitable diluent, such as bacteriostatic water or sterile water, to create a solution for injection.
It’s important to note that TB-500 is a synthetic peptide, and it is not available in other forms such as oral tablets or creams. The primary method of administration is through injection, either intramuscularly, intravenously, or subcutaneously, as determined by a healthcare professional.
When buying TB-500, it is essential to ensure that you are sourcing it from a reputable and reliable supplier to ensure the quality and integrity of the product.AASRAW is a reliable peptide manufacturer to trust. For wholesale peptide orders, you will get a very competitive price.
Peptide TB-500 reconstitution use guide
TB500 dosage
Given the relative paucity of published research to date on TB-500, there are no set dosage recommendations for research purposes.
Nonetheless, in the scientific and clinical studies to date, the most commonly reported dosing range of TB-500 has been 2-5 mg.TB-500 is commonly administered via subcutaneous (under the skin) or intramuscular injections, administered twice weekly, for a duration of 4 to 8 weeks, depending on the nature of the research. Some clinicians favor a higher starting dose for the initial 1 to 2 weeks, followed by a maintenance dose equal to one-half of the original dose for the 2 to 6 weeks thereafter.
How to use TB-500?
First, prepare the TB-500 solution by mixing the lyophilized powder form with bacteriostatic water or sterile water. Once mixed, draw the appropriate volume and inject it into the desired site after cleaning the injection site with an alcohol swab.
Many people prefer the intramuscular method by inserting the needle close to the injury site, while the intravenous method involves locating the right vein for injection. Alternatively, the subcutaneous method involves pushing the needle at the injury site.
After injection, gently massaging the area can promote efficient peptide distribution. It is important to consult with a healthcare professional for personalized guidance and ensure the safe and appropriate use of TB-500.
In addition, proper storage and handling of the peptide are crucial to maintain its effectiveness.
The dosage and administration information provided here is for informational purposes only and should not be considered as medical advice. Only a qualified healthcare professional can provide accurate and personalized guidance based on your unique circumstances. It is essential to prioritize your health and safety by consulting a healthcare professional before using any medication or treatment.
Who should use TB-500?
The supply of TB500 is huge. It is easy to get one because there are many TB500 for sale online. The use of TB-500 (Thymosin Beta-4) should be determined on an individual basis and under the guidance of a healthcare professional. It is commonly used in the following contexts:
Athletes and Fitness Enthusiasts: TB-500 research peptide may be used by athletes and individuals involved in intense physical activities to support muscle recovery, promote tissue repair, and potentially enhance performance. It can aid in the recovery from injuries and reduce inflammation associated with training.
Injury Recovery: Anyone with a muscle-related injury can use Tb-500.Peptide TB-500 is often used by individuals recovering from musculoskeletal injuries, such as muscle strains, ligament tears, or tendonitis. It may help promote healing, and tissue regeneration, and reduce inflammation in injured areas.
Chronic Inflammatory Conditions: Individuals with chronic inflammatory conditions like arthritis, tendonitis, or bursitis may consider using TB-500 under medical supervision. It has been studied for its anti-inflammatory properties and potential to alleviate symptoms associated with these conditions.
Regenerative Medicine: TB-500 is being researched for its potential applications in regenerative medicine. It may have potential benefits in wound healing, tissue repair, and angiogenesis (blood vessel growth), making it relevant in various medical conditions.
TB-500 safety and side effects
Although TB-500 has not been fully studied for human safety, current data suggest that it is safe and tolerable when administered correctly. Adverse effects are infrequent, transitory, and moderate. These are some examples:
- Fatigue
- Headache
- Nausea
- Dizziness
- Blurry vision
- Changes in heart rate
- Bruising at the site of injection
Nevertheless, because there is a dearth of information on either short- or long-term use in human subjects, researchers are urged to use caution while administering TB-500.Research peptides generally have a few more minor adverse effects, like:
- Changes in blood pressure
- Changes in appetite
- Pain at the site of injection
Adverse effects typically subside on their own and correspond with the use of low-grade peptide products. Such products, purchased from unauthorized suppliers, may be mislabeled or contain harmful contaminants. While a lot of peptide manufacturers sell peptides, we recommend AASRAW suppliers.
So long as you are doing everything correctly in using TB-500 (i.e.using proper injection techniques, appropriately storing and reconstituting the peptide, calculating the right dose, sourcing pharmaceutical-grade TB-500 only,etc.), it’s extremely unlikely you’ll run across these problems.
But it is indeed possible – remember, the absence of serious side effects in the few clinical studies published to date does not automatically mean they won’t exist when you use TB-500.
Where to buy TB-500 online?
You can find many TB-500 suppliers online. These websites can only legally sell the peptides for research purposes. To ensure the safety of TB-500, it is suggested that all peptides be purchased from manufacturers who meet the following credibility standards:
(1)The peptides should be designated strictly for use in research settings.
(2)The vendor should not make medical guarantees or claims as to the outcomes of peptide administration.
(3)Peptide products must come with valid certificates of analysis (CoAs).
TB-500 Testing Report-HNMR
What is HNMR and What does HNMR spectrum tell you? H Nuclear Magnetic Resonance (NMR) spectroscopy is an analytical chemistry technique used in quality control and research for determining the content and purity of a sample as well as its molecular structure. For example, NMR can quantitatively analyze mixtures containing known compounds. For unknown compounds, NMR can either be used to match against spectral libraries or to infer the basic structure directly. Once the basic structure is known, NMR can be used to determine molecular conformation in solution as well as studying physical properties at the molecular level such as conformational exchange, phase changes, solubility, and diffusion.
How to buy TB-500 from AASraw?
❶To contact us by our email inquiry system, or leave your WhatsApp number to us, our customer service representative(CSR) will contact with you in 12 hours.
❷To provide us with your inquired quantity and address.
❸Our CSR will provide you with the quotation, payment term, tracking number, delivery ways, and estimated arrival date(ETA).
❹Payment done and the goods will be sent out in 12 hours.
❺Goods received and give comments.
Author of this article:
Dr. Monique Hong graduated from UK Imperial College London Faculty of Medicine
Scientific Journal paper Author:
1. Ildiko Bock-Marquette
Department of Biochemistry and Medical Chemistry, University of Pecs, Medical School, Pecs H-7624, Hungary
2. Gabriel Sosne
Department of Ophthalmology, Visual & Anatomical Sciences, Kresge Eye Institute, Wayne State University School of Medicine,USA
3. Othman Othman
School of Life Sciences, Division of Physiology, Pharmacology & Neuroscience, University of Nottingham Medical School, Queens Medical Centre, United Kingdom
4. Harmanpreet Kaur
Department of Chemistry and Biochemistry, University of Windsor, Windsor, Ontario, Canada
In no way does this doctor/scientist endorse or advocate the purchase, sale, or use of this product for any reason. Aasraw has no affiliation or relationship, implied or otherwise, with this physician. The purpose of citing this doctor is to acknowledge, acknowledge and commend the exhaustive research and development work done by the scientists working on this substance.
References
[1] Ho EN, Kwok WH, Lau MY, Wong AS, Wan TS, Lam KK, Schiff PJ, Stewart BD.”Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry.”J Chromatogr A. 2012 Nov 23;1265:57-69. doi: 10.1016/j.chroma.2012.09.043. Epub 2012 Sep 23.PMID: 23084823
[2] Esposito S, Deventer K, Goeman J, Van der Eycken J, Van Eenoo P.”Synthesis and characterization of the N-terminal acetylated 17-23 fragment of thymosin beta 4 identified in TB-500, a product suspected to possess doping potential.”Drug Test Anal. 2012 Sep;4(9):733-8. doi: 10.1002/dta.1402. Epub 2012 Sep 7.PMID: 22962027
[3] Pipes GT, Yang J.”Cardioprotection by Thymosin Beta 4.”Vitam Horm. 2016;102:209-26. doi: 10.1016/bs.vh.2016.04.004. Epub 2016 May 31.PMID: 27450736
[4] Bock-Marquette I, Maar K, Maar S, Lippai B, Faskerti G, Gallyas F Jr, Olson EN, Srivastava D.”Thymosin beta-4 denotes new directions towards developing prosperous anti-aging regenerative therapies.”Int Immunopharmacol. 2023 Mar;116:109741. doi: 10.1016/j.intimp.2023.109741. Epub 2023 Jan 27.PMID: 36709593
[5] Belsky JB, Rivers EP, Filbin MR, Lee PJ, Morris DC.”Thymosin beta 4 regulation of actin in sepsis.”Expert Opin Biol Ther. 2018 Jul;18(sup1):193-197. doi: 10.1080/14712598.2018.1448381. Epub 2018 Mar 6.PMID: 29508629
[6] Jing J, Tian T, Wang Y, Xu X, Shan Y.”Multi-analyte screening of small peptides by alkaline pre-activated solid phase extraction coupled with liquid chromatography-high resolution mass spectrometry in doping controls.”J Chromatogr A. 2022 Aug 2;1676:463272. doi: 10.1016/j.chroma.2022.463272. Epub 2022 Jun 22.PMID: 35802965
