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Tauroursodeoxycholic acid (TUDCA) Powder (14605-22-2)

Rating: SKU: 14605-22-2. Category:

AASraw is with synthesis and production ability from gram to mass order of Tauroursodeoxycholic acid (TUDCA) Powder (14605-22-2), under CGMP regulation and trackable quality control system.

Product Description

 

Tauroursodeoxycholic acid (TUDCA) Powder (14605-22-2) video

 

 


 

Tauroursodeoxycholic acid (TUDCA) Powder (14605-22-2) Specification:

Chemical Structure: Product Name: Tauroursodeoxycholic acid(TUDCA)
Cas No.: 14605-22-2
Molecular Formula: C26H45NO6S
Molecular Weight: 499.7
Synonyms:Tauroursodeoxycholic acid,TUDCA,Tauroursodeoxycholate,Taurolite
Storage: Store at  -20°C away from light and moisture.
Documents(COA & HPLC etc.): Available

 

Tauroursodeoxycholic acid (TUDCA) Powder (14605-22-2) Description:

Chinese medicine has used animal bile for hundreds of years as a medicine to treat “heat” illnesses. It was used to relieve spasms, reduce fever, and improve visual acuity. Bile is naturally synthesized via cholesterol, consisting of compounds including taurochenodeoxycholic acid, ursodeoxycholic acid, and chenodeoxycholic acid.However, UDCA and TUDCA were first synthetically developed in 1954 in Japan.

Tauroursodeoxycholic acid powder is a bile acid taurine conjugate derived from ursoodeoxycholic acid. It has a role as a human metabolite, an anti-inflammatory agent, a neuroprotective agent, an apoptosis inhibitor, a cardioprotective agent and a bone density conservation agent. It derives from an ursodeoxycholic acid. It is a conjugate acid of a tauroursodeoxycholate.

Tauroursodeoxycholic Acid (TUDCA) is a liver aid introduced as a supplement by ThermoLife in their product Liver Longer. It looks like a good resource for preventing cholestasis, one of the major risks with 17 alkylated steroids. Tauroursodeoxycholic Acid (TUDCA) is an ambiphilic bile acid. It is the taurine conjugate form of ursodeoxycholic acid (UDCA). Humans are found to have trace amounts of TUDCA. However, bears contain large amounts of TUDCA in their bile. TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington’s disease, Parkinson’s Disease, and stroke. Recently, TUDCA has been found to have protective effects in the eye, especially concerning retinal degenerative disorders.

 

Reference:

  • Oveson BC, Iwase T, Hackett SF, Lee SY, Usui S, Sedlak TW, Snyder SH, Campochiaro PA, Sung JU (2011). “Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration”. J. Neurochem. 116 (1): 144–153. doi:10.1111/j.1471-4159.2010.07092.x. PMC 4083853. PMID 21054389.
  • Duan, WJ, Zhang, FK, Ou XJ, Zhang, T, Wang, XM, Wang, Y, Cui, Y, Zhao, XY, Jia, JD (2011). “[The clinical profiles of primary biliary cirrhosis with a suboptimal biochemical response to ursodeoxycholic acid]”. Zhonghua Gan Zang Bing Za Zhi. 19 (2): 118–120. doi:10.3760/cma.j.issn.1007-3418.2011.02.011 (inactive 2019-08-20). PMID 21492515.
  • Woo SJ, Kim JH, Yu HG (2010). “Ursodeoxycholic acid and tauroursodeoxycholic acid suppress choroidal neovascularization in a laser-treated rat model”. J Ocul Pharmacol Ther. 26 (3): 223–229. doi:10.1089/jop.2010.0012. PMID 20565307.