11α-Hydroxy canrenone Powder (192569-17-8) video
11α-Hydroxy canrenone Powder (192569-17-8) Specification:
|Chemical Structure:||Product Name:11α-Hydroxy canrenone|
|Cas No.: 192569-17-8|
|Molecular Formula: C22H28O4|
|Storage: Dry, dark· and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).|
|Documents(COA & HPLC etc.): Available|
11α-Hydroxy canrenone Powder (192569-17-8) Description:
11α-Hydroxy canrenone works same as Canrenone is an aldosterone antagonist with potassium-sparing diuretic activity. Canrenone specifically antagonizes aldosterone at the mineralocorticoid receptor in the kidneys, thereby increasing sodium excretion and inhibiting potassium excretion.Canrenone is reportedly more potent as an antimineralocorticoid relative to spironolactone, but is considerably less potent and effective as an antiandrogen.11α-Hydroxyprogesterone is an endogenous steroid and metabolite of progesterone.It is a weak antiandrogen, and is devoid of androgenic, estrogenic, and progestogenic activity
- Jürg Müller (6 December 2012). Regulation of Aldosterone Biosynthesis: Physiological and Clinical Aspects. Springer Science & Business Media. pp. 164–. ISBN 978-3-642-83120-1.
- Ford, Donald H. (1954). “EFFECT OF 11α-HYDROXYPROGESTERONE ON REPRODUCTIVE SYSTEM OF NORMAL AND PREGNANT ADULT WISTAR RATS*”. The Journal of Clinical Endocrinology & Metabolism. 14 (10): 1268–1270. doi:10.1210/jcem-14-10-1268. ISSN 0021-972X.
- Souness GW, Latif SA, Laurenzo JL, Morris DJ (1995). “11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat”. Endocrinology. 136 (4): 1809–12.