Urolithin A (1143-70-0)powder - Manufacturer Factory Supplier
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Urolithin A

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Urolithin A is a secondary metabolite of ellagic acid, a polyphenolic antioxidant, that has antiproliferative, anti-inflammatory, and anti-oxidant properties.
Noted: Urolithin A 8-Methyl Ether(CAS:35233-17-1) is an intermediate in the synthesis of Urolithin A, a major metabolite of Ellagitannin and exhibits anti-inflammatory and antioxidant properties.

Product Description

Basic Characteristics

Product Name Urolithin A
CAS Number 1143-70-0
Molecular Formula C13H8O4
Formula Weight 228.2
Synonyms 2′,7-Dihydroxy-3,4-benzocoumarin

3,8-Dihydroxy Urolithin;

Urolithin A 8-Methyl Ether;

3-Hydroxy-8-methoxy-6H-dibenzo[b,d]pyran-6-one.

Appearance White crystalline powder
Storage and Handling Dry, dark and at 0 – 4 C for short term (days to weeks) or -20 C for long term (months to years).

 

Reference

[1] Spendiff, S. et al. Mitochondrial DNA deletions in muscle satellite cells: implications for therapies. Hum. Mol. Genet. 22, 4739–4747 (2013)

[2] Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 November 2009). “Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay”. J Agric Food Chem. 57 (21): 10181–6. doi:10.1021/jf9025794. PMID 19824638.

[3] Milburn, M. V. & Lawton, K. A. Application of metabolomics to diagnosis of insulin resistance. Annu. Rev. Med. 64, 291–305 (2013).

[4] Cerdá, Begoña; Tomás-Barberán, Francisco A.; Espín, Juan Carlos (2005). “Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability”. Journal of Agricultural and Food Chemistry. 53 (2): 227–235. doi:10.1021/jf049144d. PMID 15656654.

[5] Laker, R. C. et al. Ampk phosphorylation of Ulk1 is required for targeting of mitochondria to lysosomes in exercise-induced mitophagy. Nat. Commun. 8, 548 (2017).