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Urolithin B

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Urolithin B also is a natural product with antiproliferative and antioxidant activity. Urolithin B is formed by metabolism from polyphenols found in some nuts and fruits, particularly pomegranates. Urolithin B has been shown to cross the blood brain barrier, and may have neuroprotective effects against Alzheimer’s Disease.

Product Description

Urolithin B Basic Characteristics

Product Name Urolithin B
CAS Number 1139-83-9
Molecular Formula C13H8O3
Formula Weight 212.2
Synonyms Urolithin B,





Appearance White to Light
Storage and Handling Dry, dark and 0 – 4 C for short term, or -20 C for long term.



[1] Bialonska D, Kasimsetty SG, Khan SI, Ferreira D (11 November 2009). “Urolithins, intestinal microbial metabolites of Pomegranate ellagitannins, exhibit potent antioxidant activity in a cell-based assay”. J Agric Food Chem. 57 (21): 10181–6. doi:10.1021/jf9025794. PMID 19824638.

[2] Cerdá, Begoña; Tomás-Barberán, Francisco A.; Espín, Juan Carlos (2005). “Metabolism of Antioxidant and Chemopreventive Ellagitannins from Strawberries, Raspberries, Walnuts, and Oak-Aged Wine in Humans: Identification of Biomarkers and Individual Variability”. Journal of Agricultural and Food Chemistry. 53 (2): 227–235. doi:10.1021/jf049144d. PMID 15656654.

[3] Lee G, et al. Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia. Phytomedicine. 2019 Mar 1;55:50-57.

[4] Rodriguez J, et al. Urolithin B, a newly identified regulator of skeletal muscle mass. J Cachexia Sarcopenia Muscle. 2017 Aug;8(4):583-597.

[5] Rombold JR, Barnes JN, Critchley L, Coyle EF. Ellagitannin consumption improves strength recovery 2–3 d after eccentric exercise. Med Sci Sports Exerc 2010;42:493–498.

[6] Adams LS, Zhang Y, Seeram NP, Heber D, Chen S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev Res (Phila) 2010;3:108–113.