Resveratrol is a polyphenol that is primarily found in grapes, especially grape skin. This polyphenol is a defense mechanism of the grape plants against pathogens and is only released when the plant is in danger. This compound is extracted and sold as either resveratrol powder or resveratrol powder supplements. The resveratrol extract powder is widely popular and is consumed mainly because of the antioxidant properties of the polyphenol, along with many other general benefits.
What is resveratrol powder?
Resveratrol or 3,4′,5-trihydroxystilbene is a stilbenoid and phytoalexin compound that is released by the plants when under attack or injured. The polyphenol compound has high antioxidant properties, which have been studied thoroughly ever since the first-ever detection of resveratrol in wine, in the late 1900s. Resveratrol powder is the main ingredient of supplements that promise health benefits due to the antioxidant properties of the compound. Pure resveratrol powder makes the best ingredient for these supplements as the lack of contaminants and mixed-in powders increase the potency and efficiency of the compound.
Resveratrol was first discovered in wines, and it was this discovery that provided a few possible answers to the French Paradox. The French diet is mainly based on saturated fats and unhealthy fats that are usually associated with an increased incidence of coronary heart disease in a population.
However, the incidence of CHD in French people doesn’t match the diet followed by most of those people, which led to the beginning of the term, ‘French Paradox’. As French people are known to be one of the main consumers of red wine worldwide, scientists hypothesized that it was the contents of the wine that were responsible for this paradox and they are potentially right. Resveratrol in red wine has antioxidants and other cardioprotective properties that have been postulated to protect the French against CHD despite their fat-rich diets.
Ever since its discovery, the compound has been extracted by resveratrol powder manufacturers for the synthesis of resveratrol extract powder which is then used for the production of supplements. Simultaneously, multiple different pieces of research have been initiated to study the benefits of resveratrol powder to provide concrete evidence of the benefits of the compound.
What is the source of resveratrol powder?
Resveratrol is commonly found in plants as it is their main defence mechanism. Many of the fruits and nuts consumed regularly by the population are rich in resveratrol, especially the skin of grapes. This is how wines get their high resveratrol content, the range of which is mentioned in the table below, along with the different types of wine.
|Beverage||Resveratrol (mg/100 ml)|
|Red wine||0.27||0 — 2.78|
|Rosé wine||0.12||5.00×10−03 — 0.29|
|White wine||0.04||0.00 — 0.17|
|Sparkling wine||0.009||8.00×10−03 — 1.00×10−02|
|Green grape juice||0.00508||0.00 — 1.00×10−02|
Apart from drinking wine, one can also receive resveratrol from certain foods, all of which are mentioned in the table below. The highest content of resveratrol per cup of these foods is seen in red grapes and mulberry, the consumption of both of which is highly recommended due to their high antioxidant content. Resveratrol, and other polyphenols, can be credited for these benefits of grapes and mulberry.
|Food||Serving||Total resveratrol (mg)|
|Peanuts (raw)||1 cup (146 grams)||0.01 – 0.26|
|Peanut butter||1 cup (258 grams)||0.04 – 0.13|
|Red grapes||1 cup (160 grams)||0.24 – 1.25|
|Cocoa powder||1 cup (200 grams)||0.28 – 0.46|
|Mulberry skin||1 gram||Up to 50|
However, it is worth noting that the tables above refer to the dietary sources of resveratrol. Pure resveratrol powder and most of the resveratrol powder supplements contain resveratrol that has been sourced from an Asian plant, namely, Polygonum cuspidatum or Japanese knotweed, or Asian knotweed. Resveratrol powder suppliers either source the compound from the knotweed plant or use mulberry and grape skins to make these supplements.
How does resveratrol powder work?
Resveratrol is still being studied by researchers worldwide to get a better understanding of the mechanism of action of the compound, in the human body. These pieces of research focus on animal models, in-vitro studies, and clinical studies with the main consensus being that resveratrol supplements have a direct effect on the cell membranes.
Based on the known benefits of the compound, it was easy for researchers to look specifically into biological target receptors that are normally responsible for producing these benefits.
After narrowing down the potential targets, researchers have found that resveratrol interacts with NQO2, AKT1, GSTP1, estrogen receptor beta, CBR1, and integrin αVβ. While the exact effects of the interactions between these receptors and resveratrol are not conclusively known, it can be postulated that known benefits are most likely due to these interactions. However, it would be amiss to decline the possibility of the known benefits being through other mechanisms of action. Only further research can conclusively decide.
What’s the benefit of taking resveratrol powder?
There are several benefits of taking resveratrol powder, ranging from improved cardiac health to longevity of life. These benefits have been studied extensively in animal models and some of them are being currently studied in clinical studies. These benefits include, but are not limited to:
- Antioxidant Properties
Wine is believed to have many antioxidants and these are derived from the resveratrol in the wine. Antioxidants are important to combat reactive oxygen species and free radicals in the body. The latter are unstable ions that participate in chemical reactions to produce other harmful ions for the body.
Resveratrol has been known to promote the production of antioxidant enzymes such as superoxide dismutase (SOD), thioredoxin, glutathione peroxidase-1, heme oxygenase-1, and catalase. All of these antioxidant properties of resveratrol have been experienced in the laboratory, however, it has been quite difficult for scientists to prove them in vivo. Since the bioavailability of the compound is so low, it is not known if there is enough of the compound to be able to produce these effects in the body.
Researchers had initially hypothesized that while resveratrol in the bloodstream is not enough to produce the benefits that they seek, it might be possible for metabolites of resveratrol to produce those benefits. However, this hypothesis was soon overruled by the finding that the metabolites, albeit more in concentration, had fewer antioxidant properties than resveratrol itself.
- Estrogenic and anti-estrogenic activities
It has been hypothesized that resveratrol has an estrogen-like effect mostly because the chemical structure of this polyphenol is very similar to diethylstilbestrol, a synthetic estrogen agonist. Given this fact, it is possible that resveratrol, once in the body, binds to the estrogen receptors to produce estrogen-like effects.
Working on this hypothesis, researchers designed Petri dishes to study the effect of resveratrol on estrogen receptors. It was soon found that resveratrol, based on different factors, either acted as an agonist or antagonist at the estrogen receptor. Further research is required for there to be a better understanding of the factors that result in the agonist or antagonist effects of the compound.
- Cancer Prevention
Resveratrol has been known to prevent the growth of cancer cells in the human body, and it is also known to interfere with the hallmarks of cancers, the properties of cancerous cells that allow them to multiply and evade immune-mediated death.
Features such as angiogenesis and inhibition of pro-apoptotic factors are inhibited and combated by resveratrol powder consumption. As the cancer cells aren’t allowed to grow or hide from being detected, they mostly undergo apoptosis or cell suicide. This results in the death of all cancer cells and hence, the prevention of cancers, mainly pancreatic, breast, prostatic, and thyroid cancers.
- Cardioprotective Properties
The cardioprotective properties, along with the antioxidant properties, are amongst the first ever benefits of the compound to be established. It is this benefit that helped solve the French paradox and has since been backed by scientific evidence. The exact mechanism through which resveratrol protects the heart is by improving endothelial function.
Endothelial dysfunction is a key marker of impending cardiac disease as it could lead to improper neutrophil extravasation, coagulation disorders, and even, thrombosis formation. These are all risk factors for a major cardiac event.
Resveratrol focuses on improving the function of the endothelial lining of the blood vessels to improve vessel health and improving this alone has been shown to improve cardiac health and significantly reduce the risk of developing cardiovascular conditions such as coronary artery disease.
- Treatment of Diabetes Mellitus, Type 2
Insulin resistance or decreased insulin sensitivity, and obesity are some of the major causes of type 2 Diabetes Mellitus and these are the two components that are targeted by resveratrol. It aims to improve the lipid profile to combat the issue of obesity amongst young adults, which also proves to be quite beneficial in improving their cardiac health.
Resveratrol use has also been associated with improved insulin sensitivity, hence, managing all aspects of DM. These are the effects scientists are trying to recreate in clinical studies so they can conclude with concrete scientific evidence that resveratrol powder supplements can treat, not manage, diabetes mellitus.
What are the side effects of resveratrol powder?
Resveratrol is a compound found naturally in foods that are commonly consumed all over the world. Unless one is allergic to these foods, such as grapes, peanuts, and berries, even large amounts of these foods are safe to consume.
Resveratrol has no known side effects and no toxicities have been reported either. Consumption of even large amounts of this natural stilbenoid compound isn’t associated with any adverse effects, meaning that it can be consumed safely.
As mentioned above, resveratrol has estrogenic properties and till further research concluded that it is safe for women with estrogen-sensitive cancers, supplements containing resveratrol should be avoided.
In studies performed to assess the toxicity levels of resveratrol powder, it was found that users who took over 1000 mg/day of resveratrol had mild gastrointestinal distress such as abdominal pain, flatulence, and diarrhea. More prominent diarrhea was reported by those taking over 2000 mg/day of resveratrol. However, it is important to note that these gastrointestinal problems are almost always resolved spontaneously and didn’t require medical intervention.
Similarly, due to a lack of information on whether resveratrol can cross the placenta or pass to babies through breast milk, it is recommended to avoid these supplements during pregnancy and breastfeeding. Alcohol use is not recommended during pregnancy and it is not recommended for pregnant women to attempt receiving their daily requirement of resveratrol from wine drinking.
How do you take resveratrol powder and storage?
The recommended dosage for resveratrol powder is 5 mg to 25 mg, with researchers observing peak resveratrol concentration in the human body with a single dose of 25 mg per day. The supplement is well-tolerated in general and absorbed well when taken orally. However, it doesn’t stay in the body as resveratrol for long due to quick metabolization and elimination of the compound.
Resveratrol is conjugated for elimination, with glucuronic acid and sulfates, giving rise to resveratrol glucuronides, sulfates, and/or sulfoglucuronides. The resveratrol that has been conjugated with sulfates is the one that is most often detected in human urine and plasma and is the one that takes the longest to be eliminated.
Overall, the bioavailability of the compound is low at only 0.5%, and it is this excessively low bioavailability that has made scientists ponder if the consumption of resveratrol powder has any effects on human health at all.
Whether buying resveratrol powder wholesale or resveratrol powder bulk amounts, it is crucial to look into the storage facilities at the specific resveratrol powder factory for the vendor that has been chosen.
Improper storage facilities that allow excessive sun exposure or have water seeping through the powder can contaminate the powder and either make it harmful for human consumption or render it useless. What this means is that it will cause negative side effects or have no effects and benefits, whatsoever.
As important as the manufacturing process is, the storage protocols are equally important and should be looked into extensively before deciding to be included in a resveratrol powder buy from a vendor.
Moreover, the manufacturing protocol as in the safety guidelines used by the resveratrol powder manufacturers should be looked into as well. Any addition of a contaminant or toxin at this stage that goes unchecked can be the reason for maximal body harm. A vendor with frequent recalls of products should be avoided if the intention is to purchase the best resveratrol powder supplement.
How to choose the best resveratrol powder supplement?
The best resveratrol powder supplement is a product that is manufactured with strict attention to the guidelines and protocols along with proper storage of the end-product. Moreover, it has to contain the required amount of resveratrol per serving so that consumers can experience the benefits of the supplement firsthand.
It should be pure resveratrol powder and not have any other compound combined with it as that could potentially reduce the efficiency and absorption of the former. Any supplement that does not meet these criteria, even in the slightest, should be avoided to ensure that a better supplement is being used which is guaranteed to provide all the benefits of resveratrol.
Resveratrol Powder Application
Resveratrol powder is predominantly used for its antioxidant, cardioprotective, cancer prevention, and cognitive benefits.
Resveratrol Powder Interactions
Resveratrol powder is found to be safe for human consumption with no reported adverse effects even with consumption of large amounts. However, if it is taken with a few other medications, it can produce significant distress and health deterioration.
Before starting any supplement, it is recommended to have a detailed conversation with the primary care doctor about any medications that are being taken or were being taken until recently. This allows the physician to best recommend if a waiting period is required or if either the medication or the supplement’s use needs to be discontinued.
Resveratrol powder can interact with quite a few medications, which are mentioned below:
One of the effects of resveratrol that was recently discovered is that the polyphenol can inhibit the aggregation of platelets, which is a crucial step in the coagulation of blood. Due to this effect, people taking resveratrol are at high risk of bruising easily and bleeding. This, when combined with the effects of anticoagulants, is exaggerated and can result in nearly life-threatening bleeding due to excessive blood thinning. Taking these together is never recommended.
- Drugs metabolized by CYP enzymes
Resveratrol is a common CYP enzyme inhibitor. The CYP enzymes are important for the metabolism of many drugs in the liver, and when drugs that undergo first-pass metabolism through the liver are taken with resveratrol, they will not be metabolized properly. Instead, the active forms of these medications will stay in the human system, exaggerating their effects which often results in more harm than good.
Reviews On Resveratrol Powder
Resveratrol powder Reddit reviews are almost completely positive with users swearing by the benefits. All the hypothesized benefits of the product are being experienced by users worldwide, resulting in a high rating of 4.7 stars out of 5 stars for this product, online. One user who had a history of cardiac disease left this review for resveratrol powder, ‘I have had 3 heart attacks and had 20% heart damage.
So I started resveratrol treatment, started 500mg first week next two weeks bumped my dose up to 1000mg after the first month I started to feel better no more chest pain(angina) at 60 days I jumped up to 2000mg or 2grams of resveratrol. now I feel better than before my first M.I. I saw my cardiologist explain to him my own treatment plan, He was skeptical so he ordered an echocardiogram and had WOW he said I saw these results before, He said a man with 3 M.Is over 40 years old, all heart damage appeared to be gone with a 10% increase in heart function, So I swear by resveratrol and every single one of us should be on this vitamin.’
Users are generally happy with the product and most of them are such firm believers in the effects of the supplement, that they would happily recommend it to their friends and family.
Resveratrol is a stilbenoid type of polyphenol that is primarily found in the skins of grapes and berries. It has many benefits, especially cardioprotective features and antioxidant properties, that are responsible for the wide use of the resveratrol powder supplements but it is worth noting that all these effects are not backed by scientific data. Resveratrol powder is safe for human consumption, and even in large amounts, causes mild to moderate gastrointestinal side effects that almost always resolve spontaneously. Overall, resveratrol is a safe, well-absorbed polyphenol with low bioavailability and several benefits.