Everything about Rimonabant powder
Rimonabant powder video
I.Raw Rimonabant powder basic Characters:
|Color:||White or off white Crystalline powder|
Rimonabant powder became available in UK in the beginning of July 2006 and by 2008, there were 56 countries where it was available. It was meant for people with a BMI greater than 30 or people whose BMI was greater than 27 but who had other risk factors like dyslipidemia and type 2-diabetes.
In June 2006, European Commission approved its sale and it was submitted to FDA for US approval. However, FDA’s EMDAC voted against the drug, concluding that Sanofi-Aventis, the manufacturers of Rimonabant raw powder, had not demonstrated its safety effectively. In 2009, EMEA withdrew Acomplia, after suspending it in 2008, because of severe psychological side effects of the drug, such as suicidal tendencies. FDA never approved Rimonabant powder and therefore, it has never been marketed in the US.
Rimonabant powder is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. It is an inverse agonist for the cannabinoid receptor CB1. Its main avenue of effect is reduction in appetite. Rimonabant raw powder is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant raw powder is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States. This decision was made after a U.S. advisory panel recommended the medicine not be approved because it may increase suicidal thinking and depression.
Other names for Rimonabant powder are Zimulti, Acomplia, Monaslim, Bethin, Riobant, Remonabent, Rimoslim and Riomont.
|Product Name||Rimonabant powder|
|Color||White or off white Crystalline powder|
Rimonabant raw powder is a specific CB1 cannabinoid receptor antagonist. There is considerable evidence that the endocannabinoid (endogenous cannabinoid) system plays a significant role in appetitive drive and associated behaviours. It is therefore reasonable to hypothesize that the attenuation of the activity of this system would have therapeutic benefit in treating disorders that might have a component of excess appetitive drive or over-activity of the endocannabinoid system, such as obesity, ethanol and other drug abuse, and a variety of central nervous system and other disorders.
• Rimonabant powder acts by selectively blocking CB1 receptors found in the brain and in peripheral organs important in glucose and lipid (or fat) metabolism, including adipose tissue, the liver, gastrointestinal tract and muscle2.
• Rimonabant powder switches off the same brain circuits that make people hungry when they smoke cannabis.
• CB1 receptor blockade with Rimonabant raw powder acts to decrease the overactivity of the endocannabinoid system (EC system).3,4 The EC system is a recently characterised physiological system that includes receptors such as the CB1 receptor and it has been shown to play an important role in regulating body weight and in controlling energy balance, as well as glucose and lipid (or fat) metabolism.
• Rimonabant powder was studied to be used complementary to diet and exercise to treat obese or overweight patients who suffer from type 2 diabetes and abnormal levels of fat in the blood.
• Sanofi argued that Rimonabant powder could also prevent the risk of cardiovascular disease.
• Patients with large waist circumference (102 cm in men and 88 cm in women) were said to most benefit from taking the drug.
Rimonabant powder is the first drug of a new class of medications that seems to reduce body weight and improve risk factors for diseases of the blood vessels and heart in people who are overweight or obese. We found four studies which evaluated weight loss, occurrence of disorders and adverse effects of treatment. The four studies involved 6625 people comparing Rimonabant raw powder 20 mg with Rimonabant powder 5 mg and placebo, in combination with a hypocaloric diet after one or two years of treatment. Greater weight loss and improvement in risk factors were seen after 20 mg of Rimonabant raw powder. These results have to be interpreted with caution though, due to high discontinuation rates of study participants and the overall low quality of the included studies.
We conclude that: average weight loss with Rimonabant powder appears modest and more rigorous studies examining the efficacy and safety of Rimonabant raw powder are required to fully evaluate the benefit risk ratio of this new drug.
In Europe, Rimonabant powder is contraindicated for patients with severe depression and/or patients who are treated with antidepressive medications. Rimonabant raw powder is furthermore not recommended for patients with other untreated psychiatric conditions.
Rimonabant powder are taken by mouth. The recommended frequency of using Rimonabant raw powder is once daily. The maximum single dose of Rimonabant powder is 20mg.
Rimonabant raw powder should be taken in the morning before breakfast. Regardless of obesity severity, Rimonabant raw powder should be taken every day. The maximum recommended duration of using Rimonabant powder is 24 months.
• An adjustment of Rimonabant powder dosing regimen is not required in elderly patients under 75 years old. Patients over 75 years old should take Rimonabant powder with caution.
• Reduction of Rimonabant raw powder daily dose is not required in patients with mild hepatic insufficiency. The reduction of Rimonabant powder single dose may be required in patients with moderate hepatic insufficiency. Patients with severe hepatic insufficiency should not take Rimonabant raw powder.
• Change of Rimonabant powder dosage is not required in patients with mild and moderate renal diseases. If severe renal disease is diagnosed in a patient, he should refrain from the use of Rimonabant powder.
• Adolescents under 18 years old were not involved in clinical and post-marketing studies of Rimonabant raw powder. Therefore, Rimonabant powder should not be used as a long-term therapy of adolescent obesity.
If you want to buy Rimonabant powder online but have never taken these weight loss tablets, get to know the side effects and potential risks of Rimonabant raw powder. Before buying Rimonabant powder online no prescription, you can get the information about this weight loss drug by email.
10. Advantages of Rimonabant powder & the Rimonabant powder benefits
This supplement has the following benefits:
• It helps obese and overweight people to lose* weight in the safest and easiest way possible. Normally obesity and diabetes go hand in hand and the supplement also helps decrease* the symptoms of diabetes so that the user does not only cut weight but also gets relief from diabetes.
• The supplement can be purchased online meaning that finding it is easier and it also comes with a 30 day money back guarantee. Therefore, if there is a problem with the product or if it does not work for you are assured of getting your money.
• It also comes at an affordable price with small pills that can be easily swallowed. Only pill is recommended daily to achieve weight loss* so you do not have to worry about taking several pills a day and sometimes forgetting some doses.
• The supplement comes packaged well and labeled clearly with all ingredients and their amounts. This enables the user to know exactly that what they are taking is clinically proven and to determine if they have any sensitivity to the ingredients in advance.
• While using Rimonabant powder you do not need to starve yourself all go through painful and intense workouts. Normal house chores and walks are enough to give you effective results.
Rimonabant powder is not recommended in pregnancy and is contraindicated in breast-feeding women.15 The SPC advises “caution” if the drug is used to treat patients with “moderate hepatic impairment”. Rimonabant raw powder is not recommended in patients with “severe hepatic impairment” and should not be used in patients with “severe renal impairment”.15 The SPC states that Rimonabant powder should not be started in patients with uncontrolled serious psychiatric illness such as major depression, and that appropriate treament for the psychiatric condition should be started first and Rimonabant raw powder therapy considered once the condition is controlled. However, it also states that the use of Rimonabant powder in combination with antidepressant medication is not recommended, because of limited data.
The side effects of Rimonabant raw powder are so many that they effectively counteract any positive effects that it may present. Even during the trials, it was reported that 1 patient out of every 8 dropped out of the said trials since the side effects became intolerable for them.
The biggest and the most adverse effects, however, were psychological. Depression has come to get associated as a severe side effect of Rimonabant powder. This depression was so serious that it required medical treatment to be managed. Because of Rimonabant powder’s effectiveness against smoking, many people used it for smoking cessation and suffered from suicidal depression.
Many patients experienced and reported extreme anxiety levels after taking Rimonabant raw powder. Nausea is another side effect which was so severe that it started interfering with the patients’ daily life.
To summarize, the adverse side effects of Rimonabant powder are many –
• Gastrointestinal Problems – One of the noted side effects are diarrhea, dry mouth, loss of appetite, nausea, vomiting and other gastrointestinal disorders.
• Skin Problems – Excessive sweating and itching has been reported.
• Musculoskeletal Problems – Joint sprains, back pain, inflammation and pain in the tendons, and spasms and cramps in muscles are common side effects.
• Central Nervous System – Depression, memory loss, anxiety, mood changes, dizziness, diarrhea and sleep disorder.
While experts speculate that if the dosage is lowered, some side effects may be managed but that still does not change the fact that the drug was never approved in the US because of the severity of its side effects. Also, the side effects that have been reported are rather serious which nullifies the drug’s positive effects against weight gain and smoking cessation.
You may be surprised by what I say in this Rimonabant powder review. We took the time to focus closely on the scientific studies, ingredients, side effects, and customer-service quality. Then we looked at user reviews from all over the internet. At last, we summarized the data we collected to give you the facts.
(1) Safety– “Serious Health Concerns”
Our first issue is the safety of the product. According to our Research Editor, “Post market analysis indicated a higher prevalence of suicidal thoughts and major depressions in patients treated with Rimonabant raw powder. The results were concerning enough to have approval revoked in a number of countries.”
One dieter said, “I was in France when this was released and it worked great but I became severely depressed. How can you be that sad and losing weight?” Another claimed, “I was willing to try anything when I was at my heaviest. The side effects were brutal, nothing is worth feeling like that.”
Others did not experience the debilitating depression as a side effect and had a more positive experience. One explained, “It worked great for me and I lost the weight I needed. I didn’t have a problem.” Another said, “I wasn’t as happy as I normally am while I was taking it but it worked so well I would totally use it again.”
(2) Availability– “Not Approved in Most Countries”
It is very difficult to find Rimonabant powder now because it has been banned in the countries where it was once available. One disappointed dieter said, “I loved it when I used it before but now I can’t find it anywhere!”
Another complained, “I don’t understand why when something works that can’t be enough for everyone. They take away all the useful options.” Some were appreciative of the safety measures. One consumer said, “I liked that it worked so well but it was dangerous. I’m hoping the company tweaks the formula so I can get it again.”
Another claimed, “I still have access to it so it isn’t as big of a deal to me. It isn’t easy but I can get it.” According to our research, safety and availability are two of the major concerns for dieters. If a product isn’t safe, it is difficult to trust that Rimonabant raw powder will lead to improved health overall and that ruins your chance of lasting results.
(3) The Science – “Strong Clinical Support?”
At DietSpotlight, we are primarily concerned with how effectively a product works. In the case of Rimonabant powder, the studies indicated it worked quite well for the majority of dieters. However, the science also shows that a greater number of participants had side effects that could have resulted in their death. This is simply unacceptable.
Rimonabant powder tablet is formulated from the following ingredients which are known to support rapid weight loss* in the body safely:
• Rimonabant raw powder– This is the active ingredient in the supplement and also where it gets its name from. It helps in suppressing the user’s appetite and also increasing* metabolism in the body leading to increased rate of burning fat.
• Meratrim – This is a clinically researched and approved ingredient that helps to lose* fat around the waist where most of the bad fat is contained. It ensures safe weight loss* and also that the user gets back into that attractive figure.
• Chromium Polynicotinate – This is a combination of chromium and niacin and it increases* the absorption of the supplement into the user’s body. This ensures that the supplement works effectively.
• Rimonabant powder (Zimulti in the US) was studied by Sanofi-Aventis as an aid to smoking cessation based on studies for up to one year in over 6,500 smokers motivated to quit smoking.
• Sanofi-Aventis submitted a New Drug Application to the FDA, which in turn issued a non-approvable letter for Rimonabant raw powder for use in smoking cessation. In June of 2007, the FDA’s Endocrine and Metabolic Drugs Advisory Committee recommended against the approval of Rimonabant powder due to concerns over serious side effects such as suicidality.
• In clinical studies, Rimonabant powder was has been shown to improve a wide array of cardiometabolic risk factors as well as promoting sustained weight loss.5,6
• Approximately half of the observed improvement in HDL-cholesterol, triglycerides and HbA1C (an indicator of blood sugar control) in patients who received Rimonabant raw powder 20mg was beyond that expected from weight loss alone.
• Serious psychological adverse effects, such as suicidality and depression led to the eventual global withdrawal of Rimonabant powder by Sanofi-Aventis.
Blockade of the endocannabinoid receptor reduces obesity and improves metabolic abnormalities such as triglycerides, HDL cholesterol, and fasting blood glucose. We assessed whether Rimonabant powder would improve major vascular event-free survival.
This double-blind, placebo-controlled trial was undertaken in 974 hospitals in 42 countries. 18 695 patients with previously manifest or increased risk of vascular disease were randomly assigned to receive either Rimonabant raw powder 20 mg (n=9381) or matching placebo (n=9314). Randomisation was stratified by centre, implemented with an independent interactive voice response system, and all study personnel and participants were masked to group assignment. The primary endpoint was the composite of cardiovascular death, myocardial infarction, or stroke, as determined via central adjudication. Analysis was by intention to treat. This study is registered with ClinicalTrials.gov, number NCT00263042.
At a mean follow-up of 13·8 months (95% CI 13·6–14·0), the trial was prematurely discontinued because of concerns by health regulatory authorities in three countries about suicide in individuals receiving Rimonabant raw powder. All randomised participants were analysed. At the close of the trial (Nov 6, 2008), the composite primary endpoint of cardiovascular death, myocardial infarction, or stroke occurred in 364 (3·9%) patients assigned to Rimonabant raw powder and 375 (4·0%) assigned to placebo (hazard ratio 0·97, 95% CI 0·84–1·12, p=0·68). With Rimonabant raw powder, gastrointestinal (3038 [33%] vs 2084 [22%]), neuropsychiatric (3028 [32%] vs 1989 [21%]), and serious psychiatric side-effects (232 [2·5%] vs 120 [1·3%]) were significantly increased compared with placebo. Four patients in the Rimonabant powder group and one in the placebo group committed suicide.
The premature termination of this trial has important lessons for drug development. A drug that was being marketed for weight loss, but being tested for improving cardiovascular outcomes, induced a level of serious neuropsychiatric effects that was deemed unacceptable by regulatory authorities, and both the drug and the trial were abruptly terminated.
(1) Buy Rimonabant powder Questions & Answers
Q: What are the ingredients in Rimonabant raw powder?
A: Rimonabant powder is the major ingredient contained in this drug.
Q: What are the side effects of Rimonabant raw powder?
A: Rimonabant raw powder can induce mental issues such as depression in the users. Furthermore, this drug is also known to induce suicidal tendencies in the user as well as abnormal changes in moods. Other side effects may include itching and excessive sweating.
Q: How do I know if Rimonabant raw powder is right for me?
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Q: Does Rimonabant raw powder work?
A: Yes, the drug stood true to its claims and helped its users to reduce their appetite, thereby curbing obesity.
Q: What is the price of Rimonabant powder?
A: The price of Rimonabant raw powder is 2600/kg, USD350/100g. The min purity is 98%.
Q: Where can I buy Rimonabant raw powder?
A: You can order Rimonabant raw powder online at www.aasraw.com
Q: How should I take Rimonabant powder?
A: Rimonabant powder is available in a low dose of 5mg to a high dose of 20mg. Your need for it and how to administer it must come from the advice of a diet expert. Rimonabant raw powder is not set out to work alone. It is designed to be used in conjunction with proper diet and exercise to improve a person’s wellbeing while reducing the size of your waistline.
Q: How do I contact Rimonabant raw powder customer service?
A: • To contact us by our email inquiry system,or online skypecustomer service representative(CSR).
• To provide us your inquired quantity and address.
• Our CSR will provide you the quotation, payment term, tracking number, delivery ways and estimated arrival date(ETA).
• Payment done and the goods will be sent out in 12 hours(For order within 10kg).
• Goods received and give comments.
Q: Can I return Rimonabant raw powder?
A: Yes, Rimonabant powder can be returned according to the return policy of its distributor or supplier.
Q: What are the most common complaints about Rimonabant raw powder?
A: Some consumers have raised complaints regarding the unsettling side effects of Rimonabant powder.
(2) Rimonabant raw powder for sale
There are a lot of weight loss products on the market, and Rimonabant raw powder is one of them, which is loved by many obese people. While Rimonabant powder is prohibited to use in many countries, but because of its powerful control appetite in order to reach the effect reducing weight, still have a large demand in the market, the corresponding Rimonabant raw powder suppliers will emerge. The well-known supplier is AASraw, the user feedback is very good, and has a great advantage in logistics.
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Buy Rimonabant powder from AASraw, you can get:
– High Quality With Competitive Price :
1) Purity: >99%
2) We are manufacturer and can provide high quality products with factory price.
– Fast And Safe Delivery :
1) Parcel can be sent out in 24 hours after payment. Tracking number available
2) Secure and discreet shipment. Various transportation methods for your choice.
– We Have Clients Throughout The World :
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet their desire.
2) Market feedback and goods feedback will be appreciated, meeting customers’ requirement is our responsibility.
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2)Never change: The product will always maintain high purity, will not change,High quality is the culture of our company.
3)Good services: As quickly as possible to solve customer problems, so that customers receive the goods safely.
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