Obesity increases the risk of serious health conditions, including diabetes, heart disease, stroke, and certain cancers. Losing weight as part of weight management can greatly help reduce the risk of these potentially fatal diseases. If you’re overweight or obese, you should consider adding Sibutramine into your weight management program. Here’s our in-depth Sibutramine powder review to help you get all the relevant information about this drug.
Chemical Properties of Sibutramine
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Sibutramine is a weight loss drug that acts as an appetite suppressant. This drug has been sold under different brand names, including Meridia powder, Sibutrex, Siredia, and Reductil. In the United States, the drug is categorized under Schedule IV Controlled Substances, and it has always been utilized in the form of hydrochloride monohydrate salt.
When Sibutramine was first formulated, it was intended for use as an antidepressant. Unfortunately, the drug wasn’t very successful in treating depression. This drawback was, however, a blessing in disguise for overweight and obese patients. Depressed patients noted that the drug reduced caloric intake and decreased appetite, thus helped them lose weight. In 1997, Sibutramine was approved by FDA for use as a weight loss medication in the United States.
Action Mechanism of Sibutramine
Sibutramine is said to be a product of 2 active metabolites – didesmethyl Sibutramine powder (M2;BTS-54505) and desmethylsibutramine (M1;BTS-54354), with much greater potency as MRIs.
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In humans, Sibutramine powder , which is a monoamine reuptake inhibitor, minimizes the reuptake of certain substances at certain levels. For example, it reduces dopamine by 16 percent, serotonin by 54 percent, and norepinephrine by 73 percent. In so doing, the levels of these substances in synaptic clefts is increased, thus helps increase satiety.
Fenfluramine and amphetamine are older anorectic agents that force the discharge of these neurotransmitters, instead of affecting their reuptake. Dissimilar to other serotonergic drugs that suppress appetite such as fenfluramine, sibutramine along with its metabolites have only low and probable insignificant affinity for the 5-HT2Creceptor.
About 77 percent of Sibutramine is well-absorbed from the gastrointestinal tract. However, the drug undergoes substantial first-past metabolism, minimizing its bioavailability. The drug attains its peak plasma level after just one hour. It also has a half-life of one hour.
Use of Sibutramine powder
Since Sibutramine was found to be effective in suppressing appetite, it has been used as a weight loss drug by patients with adverse weight problems. When taken, Sibutramine causes an effect on chemicals in the brain that affect weight maintenance.
If you are suffering from any weight-related problem such as high blood pressure, high cholesterol, or diabetes, it’s advisable that you combine Sibutramine with other weight management methods such as exercising and dieting.
There have been many randomized controlled studies meant to investigate the weight loss effect of sibutramine. In one study, 1047 obese volunteers undertook different doses of placebo or sibutramine for a duration of six months. The baseline weight loss with placebo was 2.7 percent, 7.4 percent with 25 milligram/day, 6.1 percent with 10 milligram/day, and 3.9 percent with 5 milligram/day.
In another study spanning six months, sibutramine or placebo was used in combination with a very low-calorie diet. 86 percent of those who took sibutramine managed to lose not less than 5 percent of their baseline weight. As for those who took placebo, they managed to lose about 55 percent. Within 12 months of continued use, 75 percent of those who used sibutramine maintained their weight loss, compared to 42 percent of those who took placebo.
In another randomized controlled trial involving 605 volunteers, a different method was put to test. The volunteers were given 10 milligram of sibutramine per day in addition to a very low-calorie diet. Those who managed to lose at least 5 percent of their baseline weight were randomized to go on taking placebo or 10 milligrams of sibutramine every day for another 18 months. 80 percent of those who took sibutramine managed to maintain their weight loss, compared to only 16 percent of those who took placebo.
The recommended sibutramine dosage is 10 milligrams per day, which should be taken orally.
Depending on your tolerance or clinical effect of the drug, your doctor may change your dose to ensure that you get the best possible results.
For instance, your doctor may adjust your daily dose to 5 milligrams or up to 15 milligrams per day.
It’s important to note that use of Sibutramine should be limited to 2 years.
Precautions when Taking Sibutramine powder
There are certain instances where Sibutramine shouldn’t be used. They include:
- Do not take Sibutramine if you are younger than 16 years or older than 65 years.
- You should discontinue using Sibutramine if you develop an allergic reaction from it.
- Should you experience serious Sibutramine side effects, it’s advisable that you stop taking the weight loss drug immediately.
- You shouldn’t take the drug if you have severe high blood pressure.
- Refrain from using Sibutramine if you have a history of stroke, heart disease, coronary artery disease, gall stones, glaucoma, liver disease, kidney disease, underactive thyroid, bleeding disorder, or seizures.
- Avoid taking the drug if you have a severe eating disorder such as bulimia or anorexia.
What to Avoid while Taking Sibutramine
The following shouldn’t be taken together with Sibutramine:
- Stimulant diet pills
- Cough and cold or allergy medications
- Alcohol or drugs.
- MAO inhibitors – tranylcypromine, selegiline, rasagiline, phenelzine, isocarboxazid and furazolidone.
- Prescription and/or over-the-counter weight loss products
Before taking Sibutramine, it’s imperative that you inform your doctor about any health conditions you may be suffering from. You should also inform the doctor about the over-the-counter and prescription medications you are currently using. This includes migraine headache medications, narcotic pain medications, allergy or cold medications, or antidepressants.
If you fail to lose at least 4 pounds after taking Sibutramine along with a low calorie diet after a duration of 4 weeks, it’s of essence that you inform your doctor.
What to Do if You Miss a Dose
For best results, it’s advisable to take your daily dose around the same time every day. If you miss a dose, don’t even think about taking extra medicine to make up for the missed one. Instead, you should either take the dose as soon as you remember, or skip the missed dose if it’s almost time for the next scheduled dose.
What to Do if You Overdose on Sibutramine powder
If you take a higher dose of Sibutramine than the recommended daily dose, you may experience overdose symptoms such as dizziness, fast heart rate, and headache. In case you overdose on Sibutramine, it’s important to seek emergency medical attention at once. Alternatively, you can call the Poison Help Line.
- National Library of medicine, Institute of health,Sibutramine overview, page 1-3
- Nisoli E, Carruba MO (October 2000). “An assessment of the safety and efficacy of sibutramine, an anti-obesity drug with a novel mechanism of action”. Obesity Reviews. 1(2): 127–39.
- Rothman RB, Baumann MH (May 2009). “Serotonergic drugs and valvular heart disease”. Expert Opinion on Drug Safety. 8(3): 317–29.