The most effective weight loss powder: Sibutramine powder(Meridia)

Obesity increases the risk of serious health conditions, including diabetes, heart disease, stroke, and certain cancers. Losing weight as part of weight management can greatly help reduce the risk of these potentially fatal diseases. If you’re overweight or obese, you should consider adding Sibutramine into your weight management program. Here’s our in-depth Sibutramine powder review to help you get all the relevant information about this drug.

Chemical Properties of Sibutramine

DRUG STRUCTURE MOLECULAR FORMULA CAS REGISTRY NUMBER

Sibutramine

AASRaw provideds purity 99% Sibutramine hydrochloride/Sibutramine HCL raw powder to bodybuilders or underground labs for fat loss usage. C17-H26-Cl-N  106650-56-0

 

What is Sibutramine

Sibutramine is a weight loss drug that acts as an appetite suppressant. This drug has been sold under different brand names, including Meridia powder, Sibutrex, Siredia, and Reductil. In the United States, the drug is categorized under Schedule IV Controlled Substances, and it has always been utilized in the form of hydrochloride monohydrate salt.

When Sibutramine was first formulated, it was intended for use as an antidepressant. Unfortunately, the drug wasn’t very successful in treating depression. This drawback was, however, a blessing in disguise for overweight and obese patients. Depressed patients noted that the drug reduced caloric intake and decreased appetite, thus helped them lose weight. In 1997, Sibutramine was approved by FDA for use as a weight loss medication in the United States.

 

Action Mechanism of Sibutramine

Sibutramine is said to be a product of 2 active metabolites – didesmethyl Sibutramine powder (M2;BTS-54505) and desmethylsibutramine (M1;BTS-54354), with much greater potency as MRIs.

Sibutramine (and Metabolites)
Compound DAT SERT NET
Sibutramine 943-1,200 298-2,800 350-5,451
Didesmethylsibutramine 45 20 15
(S)-Didesmethylsibutramine 12 4,300 62
(R)-Didesmethylsibutramine 8.9 140 13
Desmethylsibutramine 49 15 20
(S)-Desmethylsibutramine 180 9,200 870
(R)-Desmethylsibutramine 12 44 4
Values are Ki (nM).

 

In humans, Sibutramine powder , which is a monoamine reuptake inhibitor, minimizes the reuptake of certain substances at certain levels. For example, it reduces dopamine by 16 percent, serotonin by 54 percent, and norepinephrine by 73 percent. In so doing, the levels of these substances in synaptic clefts is increased, thus helps increase satiety.

Fenfluramine and amphetamine are older anorectic agents that force the discharge of these neurotransmitters, instead of affecting their reuptake. Dissimilar to other serotonergic drugs that suppress appetite such as fenfluramine, sibutramine along with its metabolites have only low and probable insignificant affinity for the 5-HT2Creceptor.

About 77 percent of Sibutramine is well-absorbed from the gastrointestinal tract. However, the drug undergoes substantial first-past metabolism, minimizing its bioavailability. The drug attains its peak plasma level after just one hour. It also has a half-life of one hour.

 

Use of Sibutramine powder

Since Sibutramine was found to be effective in suppressing appetite, it has been used as a weight loss drug by patients with adverse weight problems. When taken, Sibutramine causes an effect on chemicals in the brain that affect weight maintenance.

If you are suffering from any weight-related problem such as high blood pressure, high cholesterol, or diabetes, it’s advisable that you combine Sibutramine with other weight management methods such as exercising and dieting.

There have been many randomized controlled studies meant to investigate the weight loss effect of sibutramine. In one study, 1047 obese volunteers undertook different doses of placebo or sibutramine for a duration of six months. The baseline weight loss with placebo was 2.7 percent, 7.4 percent with 25 milligram/day, 6.1 percent with 10 milligram/day, and 3.9 percent with 5 milligram/day.

In another study spanning six months, sibutramine or placebo was used in combination with a very low-calorie diet. 86 percent of those who took sibutramine managed to lose not less than 5 percent of their baseline weight. As for those who took placebo, they managed to lose about 55 percent. Within 12 months of continued use, 75 percent of those who used sibutramine maintained their weight loss, compared to 42 percent of those who took placebo.

In another randomized controlled trial involving 605 volunteers, a different method was put to test. The volunteers were given 10 milligram of sibutramine per day in addition to a very low-calorie diet. Those who managed to lose at least 5 percent of their baseline weight were randomized to go on taking placebo or 10 milligrams of sibutramine every day for another 18 months. 80 percent of those who took sibutramine managed to maintain their weight loss, compared to only 16 percent of those who took placebo.

 

Sibutramine powder Dosage

The recommended sibutramine dosage is 10 milligrams per day, which should be taken orally.

Depending on your tolerance or clinical effect of the drug, your doctor may change your dose to ensure that you get the best possible results.

For instance, your doctor may adjust your daily dose to 5 milligrams or up to 15 milligrams per day.

It’s important to note that use of Sibutramine should be limited to 2 years.

 

Precautions when Taking Sibutramine powder

There are certain instances where Sibutramine shouldn’t be used. They include:

  • Do not take Sibutramine if you are younger than 16 years or older than 65 years.
  • You should discontinue using Sibutramine if you develop an allergic reaction from it.
  • Should you experience serious Sibutramine side effects, it’s advisable that you stop taking the weight loss drug immediately.
  • You shouldn’t take the drug if you have severe high blood pressure.
  • Refrain from using Sibutramine if you have a history of stroke, heart disease, coronary artery disease, gall stones, glaucoma, liver disease, kidney disease, underactive thyroid, bleeding disorder, or seizures.
  • Avoid taking the drug if you have a severe eating disorder such as bulimia or anorexia.

 

The most effective weight loss powder: Sibutramine powder(Meridia)

 

What to Avoid while Taking Sibutramine

The following shouldn’t be taken together with Sibutramine:

  • Stimulant diet pills
  • Cough and cold or allergy medications
  • Alcohol or drugs.
  • MAO inhibitors – tranylcypromine, selegiline, rasagiline, phenelzine, isocarboxazid and furazolidone.
  • Prescription and/or over-the-counter weight loss products

Before taking Sibutramine, it’s imperative that you inform your doctor about any health conditions you may be suffering from. You should also inform the doctor about the over-the-counter and prescription medications you are currently using. This includes migraine headache medications, narcotic pain medications, allergy or cold medications, or antidepressants.

If you fail to lose at least 4 pounds after taking Sibutramine along with a low calorie diet after a duration of 4 weeks, it’s of essence that you inform your doctor.

 

What to Do if You Miss a Dose

For best results, it’s advisable to take  your daily dose around the same time every day. If you miss a dose, don’t even think about taking extra medicine to make up for the missed one. Instead, you should either take the dose as soon as you remember, or skip the missed dose if it’s almost time for the next scheduled dose.

 

What to Do if You Overdose on Sibutramine powder

If you take a higher dose of Sibutramine than the recommended daily dose, you may experience overdose symptoms such as dizziness, fast heart rate, and headache. In case you overdose on Sibutramine, it’s important to seek emergency medical attention at once. Alternatively, you can call the Poison Help Line.

 

 References

  1. National Library of medicine, Institute of health,Sibutramine overview, page 1-3
  2. Nisoli E, Carruba MO (October 2000). “An assessment of the safety and efficacy of sibutramine, an anti-obesity drug with a novel mechanism of action”. Obesity Reviews1(2): 127–39.
  3. Rothman RB, Baumann MH (May 2009). “Serotonergic drugs and valvular heart disease”Expert Opinion on Drug Safety. 8(3): 317–29.
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65 Response Comments

  • Dr. Patrick Young10/11/2018 at 5:18 am

    OK, I will send you an email to confirm the price.

  • Lusi10/10/2018 at 7:01 pm

    Как и от къде да си поръчам sibutramine…

  • admin, admin09/27/2018 at 10:22 pm

    That’s great! You can send your sibutramine order to our offical email: [email protected]. Then AASraw saler will contact with you and talk more details on sibutramine orders. Looking forward to hearing from you!

  • admin, admin09/27/2018 at 9:58 pm

    Maybe you can do that but it is difficult as we know.At the first, sibutramine is not available for some countries.Secondly, most of shops buy sibutramine powder from china in low price then sell sibutramine in their country as higher price. So I think that you can order sibutramine online once you find a reliable weight loss resouce. Hope that can help a little.

  • admin, admin09/27/2018 at 9:51 pm

    Hi Robert, it is a good question. When you take sibutramine wrongly, Your weight loss effect will not be obvious and sibutramine side effects will bring some trouble to your body. So please take sibutramine under your doctor guide, So are other weight loss drug. Thank for your question again.

  • admin, admin09/27/2018 at 9:45 pm

    Any drug has a shelf life, sibutramine is no exception. As generally, sibutramine shelf life is 2-3 years.

  • admin,09/26/2018 at 6:20 am

    That sounds great!Maybe you can buy some sibutramine for her and take sibutramine under correct sibutramine dosage, she will feel better. You are a good husband.

  • Red Anderson09/25/2018 at 9:29 am

    Nothing wrong with using this drug as it is FDA approved. Still, those who plan to take weight loss powder should first learn about, and i think this thorough article would help educate those who are interested in taking Sibutramine.

  • Marky Lee09/25/2018 at 9:27 am

    I overcame my weight problems, but im really scared that i might fall of the wagon and return back to my usual overweight self. Now, i take Sibutramine from time to time as security blanket in helping me maintain my current weight loss. Nothing wrong in using sibutramine, but i think it would be best if coupled with an active and healthy lifestyle.

  • roberachi09/24/2018 at 3:10 pm

    Sibutramine Sounds like a very important drug and very effective. But i have a question why have you insisted that Sibutramine should be limited to 2 years use?

  • Robert M09/24/2018 at 3:03 pm

    I have noticed that you have very serious conditions on how to take sibutramine medicine. How strong an effect do they have if taken sibutramine wrongly?

  • Dan Carson09/24/2018 at 2:39 pm

    The sibutramine pictures and sibutramine results show how effective the weight loss drug is. I’d love to see more once it becomes more mainstream.

  • John Herman09/24/2018 at 2:32 pm

    Wow, this sounds very effective for weight loss. The weight loss results for those who take Sibutramine compared to those who took the placebo were very impressive. Thanks for sharing.

  • Mbet09/24/2018 at 9:27 am

    Just curious to know if I can buy sibutramine in our location apart buying sibutramine online.it will be better that way.

  • Femi09/24/2018 at 9:17 am

    Helping to spread the useful of sibutramine because they’re a lot of people that really need to lose some weight.I hope it will help them to loss fat after take sibutramine.

  • Albeneth09/23/2018 at 10:55 pm

    I heard a lot of weight loss drugs online and offline. Reading the review of Sibutramine seems interesting.

  • Susan09/23/2018 at 8:18 pm

    First time hearing about this powder. Looks like an effective weight loss drug. This is really worth a try some sibutamine to loss weight.

  • Doug Brians09/23/2018 at 5:28 pm

    It’s interesting that each body type might have a different reaction to the weight loss supplement. It’s probably not a bad idea to check your vital signs and heart beat regularly while you take weight loss drugs.

  • Hank Nolan09/23/2018 at 5:22 pm

    It’s cool to break down each weight loss supplement and how they to loss weight. It’s good that everything is listed from when the sibutramine drug comes into fruition and all the precautions you should take sibutramine for daily use.

  • Sam09/23/2018 at 2:01 pm

    For those that hate injectable drugs should opt for sibutramine because it is taken sibutramine orally which I know a lot of people like.

  • Udi09/23/2018 at 1:53 pm

    The images shown on this page is really appropriate and it will help and also encouraged obesity on the big side to really take sibutramine.I hope the image there is real and help us to loss weight.

  • cess garate09/23/2018 at 7:11 am

    Wow, This is good news to all those looking for other ways to lose weight. Just hope that the side effects are acceptable and I am consider that buy sibutramine to take my fat.

  • Weightloss Police09/22/2018 at 9:31 pm

    Please note, the quality and purity is very important when you buy sibutramine powder online. Not enough that it’s cheap.

  • Mina Sib09/22/2018 at 9:28 pm

    Sibutramine is a very effective weight loss drug that acts as an appetite suppressant. It has been accepted by most of people in the world.

  • Rhona Burchill09/22/2018 at 8:58 pm

    As a woman, I need keep my shape and stay at good state. This article is very helpful for me then I plan to order some sibutramine at my side and hope that image can be real.

  • Victor09/22/2018 at 8:17 pm

    I think this diet powder is not age and gender, I intend to give my daughter and husband to buy some sibutramine. How can I get that powder?

  • Malik Vennity09/22/2018 at 7:43 pm

    It’s minimal bioavailability and its effect on neurotransmitters sound very interesting. I’m sure with a steady diet and exercise, take sibutramine could be very optimal.

  • Howy Ridell09/22/2018 at 7:37 pm

    FDA approved and peak results after taking sibutramine one hour..! I think this is a miracle drug. Seeing a fast transformation after four weeks isn’t bad either.

  • Janine Marie Alexandra Bocateja09/22/2018 at 12:54 pm

    There are 1 sibutramine powder suppliers, mainly located in Asia. The top supplying country is China (Mainland), which supply 100% of sibutramine powder respectively.

    Sibutramine powder products are most popular in Southeast Asia, Domestic Market, and North America.

  • fenny09/22/2018 at 7:28 am

    Obesity can lead to sudden death and as such people with this problem shouldnt relent in getting some of these supplements to lose weight especially if one is always with the natural ways, take some weight loss drugs to control your body.

  • idara09/22/2018 at 5:59 am

    Sibutramine should be taken according to prescription but paraadventure an overdose is taken out of whatever reasons then a medical help should be sort swiftly.

  • Arnold09/22/2018 at 3:38 am

    If many people say that this is effective I guess i could buy this for my wife. She want to lose weight and has been stressed about it but has no time to exercise since both of us works in the office.

  • Katrina09/22/2018 at 3:36 am

    weight loss drug is very popular in my world and I always hope that eat too much but my body still look great.

  • Victor palmer09/21/2018 at 10:23 pm

    I have taken many weight loss solutions in the past. This is the drug that has worked wonders for me and I want to try more weight loss powder to let me look better.

  • Mog Arten09/21/2018 at 4:36 pm

    I find it interesting that Sibutramine has low affinity for the 5-HT2Creceptor opposed to other weight loss drugs. I’d be curious to see all the chemical changes from daily usage.

  • Miles Dubager09/21/2018 at 4:32 pm

    It’s interesting all the trials and tribulations Sibutramine has gone through. I think the 80 percent of users who were able to stay fit was an impressive feat. Thanks for sharing! Sibutramine production will bring much benefits for obesity.

  • Lisa Nataliany09/21/2018 at 9:22 am

    Looks like I’ve to try this “Sibutramine powder (Meridia)”, everyone wants to have a perfect and healthy body. And through the complete information that I get here, I will try it… No more suffering from doing ineffective diets. Thank you very much!

  • Tracy Miles09/21/2018 at 8:49 am

    Sibutramine is FDA approved, which is why I take sibutramine in the first place. It’s really effective although it takes time and effort too.

  • Lance James09/21/2018 at 8:05 am

    Sibutramine is good for my weight loss and I have got a lot from sibutramine suppliers.

  • admin, admin09/21/2018 at 3:04 am

    Thank for your question, Sibutramine and lorcaserin powder will be good ideas for taking flabs from your girl according to our experience. You can send your requirments to our offical email: [email protected] if you want to try some to loss weight.

  • lovely12309/21/2018 at 1:47 am

    All couch potatoes should take this drug seriously and see how they can lose weight without much stress especially for those that cant exercise.

  • beta09/21/2018 at 1:38 am

    Great to know more informations about sibutramine powder and I am taking sibu powder now.

  • Ryan09/20/2018 at 11:46 pm

    I don’t think there will be anything hurtful about taking any of this weight loss supplements since it has been endorsed by FDA and Japan.Any of these supplements should be used for weight loss, because they are losing fat fast. Plus weight loss diet plan, you can burning you fat fast.

  • Boss09/20/2018 at 11:42 pm

    This is a good drug for weight I had to discussed it with a weight loss expert and it was highly recommended but I think it should be a little bit controlled by a physician.

  • Reuben Weru09/20/2018 at 11:25 pm

    That is a very interesting article for sibutramine. Unfortunately, the drug interaction with alcohol other medications can be quite a challenge. I do not know what happen if I mix some weight loss supplements.

  • Captain U09/20/2018 at 10:34 pm

    Frankly, I am find a best foods for weight loss but it always let me crazy. Because I have got bad weight loss powder before, so I still worry about my fat body.

  • Mach09/20/2018 at 9:40 pm

    My girl is a bit on the chubby side. Perhaps, I can suggest some weight loss drugs to her and let her stay at good shape. Where and when is this gonna be available?

  • Bradley Lavender09/20/2018 at 4:10 pm

    Sibutramine’s affinity for the 5-HT2Creceptor sound like its most outstanding feature. I could see it being very effective along with a balanced diet and regular workout schedule. Thanks for sharing!

  • Curt Rancher09/20/2018 at 4:05 pm

    It’s interesting that the drug was originally used to treat depression and it’s weight losing factor was discovered by accident. It’s definitely important to take Sibutramine daily and follow the dosage requirements.

  • David Tjoe09/20/2018 at 9:27 am

    Sibutramine looks good and it work well according to my friend said. I want to try some if possible. Because I am a fat girl and want to do change.

  • Ashley Blake09/20/2018 at 5:46 am

    I’ve been hearing about sibutramine for a while now. But I’m really afraid to try it. After reading this article, I think it’s worth giving a shot.

  • Gavin Taylor09/20/2018 at 5:43 am

    Sibutramine helped me lose significant weight but it wasn’t without hardwork. I also stayed active in the gym and resisted all sorts of junk food.

  • Bose09/20/2018 at 4:37 am

    I hope I will remember this information of taking it all the time on the same time daily. I think that routine is good,it wouldn’t make one forget easily.

  • Jones09/20/2018 at 4:31 am

    My little cousin is a bit on the obese side and I was about showing the mum this page before I read those below16 years can take this.it will have really been helpful for her.

  • Erza Scarlet09/19/2018 at 9:52 pm

    I want to know how to take sibutramine according my body and it is better to weight loss?

  • Jiffy Rando09/19/2018 at 9:48 pm

    I was reading an article on this very topic now so thanks for the additional info. I do not know what to choose to be honest but, at least chubby people van now have a choice.

  • praise09/19/2018 at 6:45 pm

    I believe the use of Sibutramine should also be controlled especially that it isn’t advisable to take it beyond 2 years and one should be sure that increased sibutramine dosage should be adjusted by an expert. You gave the best information.I am thinking about whether buy some powder to help me to lose belly fat now.

  • best09/19/2018 at 6:36 pm

    I think I have read about sibutramine earlier but I like the fact that it suppress appetite so as to hinder getting too much calories into the system in the first instance then I still keep good shape although I have enjoyed much foods.Good one there.

  • Moz Chesk09/19/2018 at 5:07 pm

    It’s cool to break down the supplement’s structural and molecular properties. All materials is benefits for me and everyone who want to keep her good shape. Thanks for sharing!

  • Maury Cheskes09/19/2018 at 4:28 pm

    Sounds like a useful drug. I found how it lowers serotonin and dopamine levels especially interesting. Thanks for sharing!

  • Moch Sugih09/19/2018 at 12:44 pm

    good article, I think all women must read this article. because only women always pay attention to their body shape and they want to know how to start losing weight, especially for how to loss weight at home and natural weight loss.

  • Dana Orwell09/19/2018 at 7:47 am

    I can attest to sibutramine’s weight loss effects. At first I was not sure about it but eventually I gave in and tried some sibutramine powder. Feel good and my shape looks better in the near the future, I’m full of information.

  • Aaron James09/19/2018 at 7:45 am

    I’ve tried all sorts of weight loss regimens before. This is the only drug that really worked for me.

  • Larry09/19/2018 at 2:49 am

    This powder is worth taking for weight loss.I will recommend Sibutramine to everyone seeking to loss weight since it has been endorse by FDA,I’m certain that it best for weight loss.

  • Perry09/19/2018 at 2:41 am

    Obesity would be badly deal with ,with lorcaserin powder weight loss drugs I read it is effective for weight loss.I hope it is easily accessible for purchase.

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