Everything about Rivaroxaban powder
Rivaroxaban powder video
I.Rivaroxaban powder basic Characters:
|Storage Temp:||-20°C Freezer|
|Color:||White to yellowish powder|
What is Rivaroxaban powder:
Rivaroxaban powder, brand name is Xarelto, and others. It is a morpholine and thiophene derivative that functions as a FACTOR XA INHIBITOR and is used in the treatment and prevention of DEEP-VEIN THROMBOSIS and PULMONARY EMBOLISM. It is also used for the prevention of STROKE and systemic embolization in patients with non-valvular ATRIAL FIBRILLATION, and for the prevention of atherothrombotic events in patients after an ACUTE CORONARY SYNDROME.
Xarelto powder is an anticoagulant which binds directly to factor Xa. Thereafter, it effectively blocks the amplification of the coagulation cascade, preventing the formation of thrombus. Rivaroxaban powder is a unqiue anticoagulant for two reasons. First of all, it is does not involve antithrombin III (ATIII) to exert its anticoagulant effects. Secondly, it is an oral agent whereas the widely used unfractionated heparin and low molecular weight heparins are for parenteral use only. Although the activated partial thromboplastin time (aPTT) and HepTest (a test developed to assay low molecular weight heparins) are prolonged in a dose-dependant manner, neither test is recommended for the assessment of the pharmacodynamic effects of Rivaroxaban powder. Anti-Xa activity and inhibition of anti-Xa activity monitoring is also not recommended despite being influenced by Rivaroxaban powder.
Rivaroxaban powder usage:
Following oral administration, Rivaroxaban powder is rapidly absorbed and reaches peak plasma concentration in 2-4 hours. Bioavailability of the 10 mg dose is >80%. However, the 15-20 mg dose have a lower bioavailability if taken in the fasted state and consequently should be taken with food.
Rivaroxaban powder metabolism:
Approximately two-thirds of Rivaroxaban powder is excreted into urine (via active tubular secretion in which approximately 36% as unchanged drug and 30% as inactive metabolism). The remaining third of the administered dose is excreted via feces in which 7% is in the form of unchanged drug and 21% as inactive metabolites.
Xarelto powder is an oral anticoagulant (blood thinner) that is used to prevent and treat blood clots. Blood clots formed in the heart are dangerous since they can travel to the brain and cause a stroke. Similarly, blood clots formed in the legs or lungs can be equally life threatening if not treated. Rivaroxaban powder(Xarelto) is a selective inhibitor of factor Xa, an enzyme necessary to form blood clots. It reduces the ability of blood to clot. The FDA approved Xarelto in July, 2011.
The terminal Rivaroxaban powder half life is 5-9 hours in adults and 11-13 hours in the elderly.
-reduce the risk of stroke and blood clots in patients with atrial fibrillation not due to a heart valve problem,
-treat and reduce the risk of deep vein thrombosis (DVT, blood clots in the veins of the legs) and pulmonary embolism (PE, blood clots in the lungs)
-reduce the risk of blood clots in the legs and lungs of patients who have just had hip or knee replacement surgery.
How to use Rivaroxaban powder?
Xarelto powder is available in 10, 15, and 20 milligram (mg) tablets(Rivaroxaban powder 20mg)that you take by mouth.
For treating DVT or PE, the typical dose is 15 mg twice daily with food for the first 21 days. After that, people usually take 20 mg(Rivaroxaban powder 20mg) once a day for the remainder of their treatment.
For nonvalvular atrial fibrillation, the typical starting Rivaroxaban powder dose is either 15 or 20 mg (ravaroxaban dosing)once in the evening, with a meal.
To prevent DVT or PE, people usually take 10 mg of Rivaroxaban powder dose once a day, with or without food.
After hip or knee replacement surgery, the usual recommendation is to start treatment at least 6 to 10 hours after surgery. People who’ve had a hip replacement generally are prescribed 10 mg of the Rivaroxaban powder dosage for 35 days.
If you’ve had a knee replacement procedure, you can take Rivaroxaban powder dosing for 12 days following surgery.
Be sure to take Xarelto powder to at about the same time each day.
If you have difficulty swallowing the tablets, you can crush them and mix them with applesauce. Eat the mixture right away, followed by additional food.
Rivaroxaban powder(Xarelto) Overdose
If you take too much Rivaroxaban powder(Xarelto) , you could bleed internally, or hemorrhage.
Symptoms of an overdose may include:
Abnormal bleeding or bruising
Bloody or black stools
Blood in urine
Coughing up blood or vomiting blood
If you or someone else has symptoms of an overdose, call your doctor right away or go to the nearest emergency room. If someone taking Xarelto collapses or isn’t breathing, call 911.
Xarelto powder Missed Dose
Be sure to take the drug as prescribed by your doctor, even if you feel well. Don’t stop taking Xarelto powder without talking to your doctor first because you’re at greater risk of stroke after you stop taking this medication.
If you’re supposed to take Rivaroxaban powder(Xarelto) once a day but miss a dose, take the missed dose as soon as you remember that day. Go back to your normal treatment schedule the next day.
If you take Xarelto powder twice a day, take the missed dose as soon as you remember it on the same day. You can take even two doses of the medication at the same time to make up for the missed dose.
The next day, stick to your usual dosing schedule.
Daily use of alcohol while using Rivaroxaban powder will increase your risk for stomach bleeding. Limit alcoholic beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink. Rivaroxaban powder can cause bleeding.
Rivaroxaban powder contraindications, what medications should not be taken with Xarelto(Xarelto powder anticoagulant)?
The CYP3A4 liver enzymes and P-glycoprotein (P-gp) drug transporter systems are primarily responsible for metabolizing and removing Rivaroxaban powder to from the body. Taking Xarelto with medicines that alter the activity of both the CYP3A4 enzymes and P-gp drug transporters may affect blood levels of Rivaroxaban powder. Xarelto powder should not be taken with:
-rifampin (Rimactane), or,
-St. John’s Wort.
Rivaroxaban powder anticoagulant to should not be used with other blood thinners due to the increased risk of bleeding.
As warfarin’s blood thinning effect sticks around for several days after it has been stopped, discontinuation 5- 7 days before surgeries is typically needed. Rivaroxaban powder, on the other hand, is relatively quickly out of the system. Discontinuation 24 to 36 hours before surgeries is typically enough.
Rivaroxaban powder has no known dietary restrictions. Xarelto powder doesn’t interact with vitamin K like warfarin does. So you can enjoy healthy options like leafy green vegetables and other foods rich in vitamin K whenever you like, without having to worry about them changing the way Rivaroxaban powder works.
You are at risk of stroke from AFib even if you don’t feel symptoms. Don’t stop taking Rivaroxaban powder(Xarelto) unless your doctor tells you to. Stopping Xarelto powder increases your risk of having a stroke. If you have to stop taking Rivaroxaban powder(Xarelto), your doctor may prescribe another blood thinner to help prevent blood clots from forming.
Along with its needed effects, a medicine may cause some unwanted Rivaroxaban powder side effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following Rivaroxaban powder side effects occur:
-bowel or bladder dysfunction
-burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings
-coughing up blood
-difficulty with breathing or swallowing
-increased menstrual flow or vaginal bleeding
-prolonged bleeding from cuts
-red or black, tarry stools
-red or dark brown urine
-vomiting of blood or material that looks like coffee grounds
-pain in the arms or legs
At a monthly cost of approximately $255 for a 20-mg daily dosage, Rivaroxaban powder cost is significantly more expensive than warfarin (approximately $6 for a 30-day supply of 1-, 2-, 2.5-, or 5-mg tablets; and between $6 and $7 for a 30-day supply of 7.5- or 10-mg tablets), and roughly the same price as dabigatran (approximately $255 for a one-month supply of 150 mg twice daily).
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